ICML 2026 论文列表

International Conference on Machine Learning

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6,341篇论文

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KAST-BAR: Knowledge-Anchored Semantically-Dynamic Topology Brain Autoregressive Modeling for Universal Neural Interpretation

Haoning Wang, Wenchao Yang, Shuai Shen, Yang Li

展开摘要

While EEG foundation models have shown significant potential in universal neural decoding across tasks, their advancement remains constrained by the inadequacy modeling of *complex spatiotemporal topology*, as well as the inherent *modality gap* between low-level physiological signals and high-level textual semantics. To address these challenges, we propose a **K**nowledge-**A**nchored **S**emantically-Dynamic **T**opology **B**rain **A**uto**r**egressive Model (KAST-BAR), which dynamically aligns physiological representations derived from multi-level brain topology with an expert-level semantic space. Specifically, we design a Dual-Stream Hierarchical Attention (DSHA) encoder that accurately captures the brain's intrinsic non-Euclidean topology by modeling local temporal dynamics with global spatial contexts. On this basis, a Knowledge-Anchored Semantic Profiler (KASP) is proposed to synthesize physically-grounded and instance-level textual profiles, which subsequently drive a Semantic Text-Aware Refiner (STAR) to dynamically reconstruct EEG representations using Latent Expert Queries. By conducting large-scale pre-training on 21 diverse datasets to build a foundation model, KAST-BAR effectively integrates expert-level medical knowledge into EEG signal representations, consistently achieving state-of-the-art performance across six downstream tasks. Our code is available at https://github.com/KAST-BAR/KAST-BAR

Poster
Crowd4D: Scene-Aware Monocular 4D Crowd Reconstruction

Hongbo Kang, Tianyi Zhou, Qingyang Yang, Hongwei Wen, Jing Huang, Yu-Kun Lai, Kun Li

展开摘要

Recovering scene-consistent 4D crowd motion from monocular video in large-scale scenes remains challenging due to severe depth ambiguity and complex scene geometry. Existing monocular crowd reconstruction methods typically rely on single-plane assumptions, leading to unreliable metric scale and spatial drift under complex terrain. We propose Crowd4D, the first scene-aware 4D crowd reconstruction framework that jointly optimizes the crowd and scene from a monocular RGB video in large-scale scenes. Crowd4D explicitly incorporates scene geometry and ensures consistency across image and scene spaces via a multi-stage optimization strategy. A key bottleneck of this task lies in accurate human–scene alignment, particularly in scale and position. However, human and scene reconstructions are typically decoupled. To address this, we introduce the Human–Scene Interaction Proxy (HSIP) as an intermediate representation, derived from Scene Interaction Point Clouds and a Scene Interaction Surface (SIPC\&SIS), which encode explicit scene-aware geometric priors and redefine the optimization space for large-scale monocular 4D crowd reconstruction. To further improve temporal stability under occlusions, we introduce Crowd Structural Coherence Regularization (CSCR), which leverages HSIP-based spatial priors to impose soft temporal consistency on pairwise relative displacements and directions within local crowd neighborhoods. Extensive experiments demonstrate that Crowd4D consistently outperforms existing state-of-the-art methods and enables robust monocular 4D crowd reconstruction in complex, large-scale real-world scenes. Project page is available at https://cic.tju.edu.cn/faculty/likun/projects/Crowd4D.

Poster
SkelHCC: A Hyperbolic CLIP-Driven Cache Adaptation Framework for Skeleton-based One-Shot Action Recognition

Yanan Liu, Anqi Zhu, Jingmin Zhu, Jun Liu, Hossein Rahmani, Mohammed Bennamoun, Farid Boussaid, Dan Xu, Qiuhong Ke

展开摘要

Skeleton-based action recognition aims to understand human behaviors from body joint sequences and is especially challenging in the one-shot setting, where only a single labeled exemplar is available for each novel action. A key challenge is learning representations that capture the hierarchical and compositional structure of human motion while aligning effectively with high-level action semantics under extreme data scarcity. Existing approaches, largely based on Euclidean embeddings and low-level motion cues, struggle to model the tree-like organization of skeleton data, limiting cross-modal alignment and generalization to unseen action categories. We propose SkelHCC, a unified skeleton hyperbolic CLIP-driven cache adaptation framework for one-shot skeleton-based action recognition. SkelHCC introduces an Explicitly Hierarchical Hyperbolic CLIP (EH-HCLIP) module that embeds skeleton sequences and action language into a shared hyperbolic space. By leveraging the negative curvature and exponential volume growth of hyperbolic geometry, EH-HCLIP naturally encodes the joint–part–body hierarchy of human anatomy and yields structurally consistent cross-modal representations. To support efficient one-shot adaptation, SkelHCC further integrates a training-free LLM-guided Multi-granularity Voting Cache (LMV-Cache) for context-aware inference. Experiments on NTU RGB+D 60, NTU RGB+D 120, and PKU-MMD II demonstrate that SkelHCC consistently outperforms state-of-the-art methods. Code will be available at https://github.com/lya19971103/SkelHCC

Poster
From Coarse to Fine: Deep Prototype Refinement Network for Few-Shot Point Cloud Semantic Segmentation

Changshuo Wang, Weijun Li, Shuting He, Xiang Fang, Xingyu Gao, Zhonghang LIU, Prayag Tiwari, Dimitrios Kanoulas

展开摘要

Few-shot point cloud semantic segmentation (FS-PCSS) aims to achieve precise segmentation of novel categories using only limited labeled samples. Existing prototype-based methods rely on shallow feature fusion, failing to adequately model the feature distribution shift between support and query sets, resulting in insufficient prototype adaptation. To address this, we propose the Deep Prototype Refinement Network (DPR-Net), which systematically achieves progressive adaptation by constructing a coarse-to-fine prototype evolution trajectory. Our core Dynamic Prototype Refinement (DPR) module decomposes features into common and distinctive subspaces based on channel activation, enabling targeted adjustment of domain-sensitive features while preserving class-shared semantics. By cascading multiple refinement modules, we construct a prototype trajectory transitioning from support-biased to query-adapted representations, mitigating both under- and over-adaptation. Furthermore, our Mixture of Prototype Experts (MoPE) mechanism treats prototypes at different stages as experts and ensembles their predictions through confidence-driven weighting. Extensive experiments demonstrate state-of-the-art performance with high efficiency. Our code will be available at https://github.com/changshuowang/DPR-Net.

Poster
GEM-FI: Gated Evidential Mixtures with Fisher Modulation

Marco Mustafa Mohammed, Fatemeh Daneshfar, Pietro Lio

展开摘要

Evidential Deep Learning (EDL) enables single-pass uncertainty estimation by predicting Dirichlet evidence, but it can remain overconfident and poorly calibrated, and it often fails to represent multi-modal epistemic uncertainty. We introduce Gated Evidential Mixtures (GEM), a family of models that learns an in-model energy signal and uses it to gate evidential outputs end-to-end in a distance-informed manner. GEM-CORE learns a feature-level energy and maps it to a bounded gate that smoothly suppresses evidence when support is low. To capture epistemic multi-modality without multi-pass ensembling, GEM-MIX adds a lightweight mixture of evidential heads with learned routing weights while preserving single-pass inference. Finally, GEM-FI stabilizes mixture allocations via a Fisher-informed regularizer, reducing head collapse and producing smoother boundary uncertainty. Across image classification and OOD detection benchmarks, GEM improves calibration and ID/OOD separation with single-pass inference. On CIFAR-10, GEM-FI vs. DAEDL improves Acc. from 91.11 to 93.75 (+2.64 pp), reduces Brier ×100 from 14.27 to 6.81 (−7.46), and also improves misclassification-detection (AUPR) from 99.08 to 99.94 (+0.86). For epistemic OOD detection, GEM-FI achieves AUPR/AUROC of 92.59/95.09 on CIFAR-10→SVHN and 90.20/89.06 on CIFAR-10→CIFAR-100 (vs. 85.54/89.30 and 88.19/86.10 for DAEDL).

Poster
Benchmarking the Limits of In-Context Reinforcement Learning for Ad-Hoc Teamwork

Yuheng Jing, Kai Li, Jiajun Zhang, Zeyao Ma, Jiaxi Yang, Lei Zhang, Zhe Wu, Jinmin He, Junliang Xing, Jian Cheng

展开摘要

In-Context Reinforcement Learning (ICRL) has enabled foundation agents to adapt instantaneously to novel tasks, yet its efficacy in Ad-Hoc Teamwork (AHT)—where coordination with unknown partners is required—remains unexplored. To rigorously evaluate this, we introduce a large-scale benchmark **ICRL4AHT**, built upon a high-throughput JAX implementation of Overcooked-V2. Our benchmark includes a large, diverse teammate suite spanning both RL and heuristic policies, enabling controlled train-test shifts, and provides a reproducible end-to-end pipeline for teammate generation, learning-history collection, dataset construction, and online multi-episode evaluation. We evaluate representative history-conditioned ICRL algorithms, including Algorithm Distillation (AD) and Decision-Pretrained Transformer (DPT), across millions of transitions. Results reveal notable limitations: contrary to their success in single-agent domains, these baselines fail to exhibit robust test-time adaptation in multi-agent settings. Specifically, these methods frequently underperform random baselines across both unseen teammate and unseen layout tracks, with no clear in-context improvement over long horizons. These findings highlight the challenges of strategic inference under partial observability within the OvercookedV2 AHT protocol, establishing our benchmark as a critical testbed for next-generation coordination algorithms.

Poster
Leveraging Gauge Freedom for Learning Non-Gradient Population Dynamics of Stochastic Systems

Jules Berman, Tobias Blickhan, Benjamin Peherstorfer

展开摘要

In existing works on population dynamics inference, there is a focus on flows arising from vector fields that are the gradients of scalar potentials. Among all admissible flows that are compatible with the population dynamic, gradient flows are optimal in a specific sense: they minimize kinetic energy. The selection of fields based on different criteria corresponds to a gauge freedom when determining population dynamics, which we leverage in this work. We propose Non-Gradient Inference Flows (NGIF), an algorithm to infer non-gradient population dynamics using a weak formulation of the continuity equation. This allows us to parameterize with general vector fields as well as choose other selection criteria beyond minimal energy. We demonstrate on a variety of low- and high-dimensional physics problems that this more general approach improves distributional accuracy over gradient-restricted baselines and better captures non-potential transport.

Poster
Listening Through the Noise: Cauchy-Driven Diffusion Bridges for Robust Gastrointestinal Auscultation and Clinical Benchmarking

Dian Ding, Liren Dong, Yu Lu, Juntao Zhou, Ran Wang, Peng Li, Zhenyi Jia, Guangtao Xue

展开摘要

Gastrointestinal (GI) motility assessment via bowel sounds (BS) offers a non-invasive alternative to resource-intensive clinical standards. However, the diagnostic utility of BS is often compromised by its spectral overlap with non-stationary speech interference. While generative models have advanced signal restoration, traditional Gaussian-based diffusion frameworks struggle with the impulsive, heavy-tailed nature of real-world clinical noise. In this paper, we propose a novel Cauchy-driven Diffusion Bridge framework to isolate high-fidelity bowel sounds from complex interference. Our contributions are three-fold: (1) We introduce ClinBS, a large-scale clinical dataset (over 25 hours) containing rare pathological transients verified by experts; (2) We mathematically formulate a Cauchy bridge driver, deriving closed-form expressions for the score and density to better model heavy-tailed perturbations; and (3) We implement an efficient sampling procedure via Gaussian scale-mixture reparameterization. Extensive experiments show our framework achieves state-of-the-art performance, outperforming baselines by 13.4%–49.8% across core metrics and elevating abnormal BS recognition accuracy to 88.01%. These results demonstrate the system's potential for robust clinical GI monitoring and diagnosis.

Spotlight
Weasel: Out-of-Domain Generalization for Web Agents via Importance-Diversity Data Selection

Fatemeh Pesaran Zadeh, Seyeon Choi, Xing Han Lù, Siva Reddy, Gunhee Kim

展开摘要

Large language models (LLMs) have enabled web agents that follow natural language goals through multi-step browser interactions. However, agents fine-tuned on specific trajectories and domain often struggle to generalize out of domain, and offline training can be compute-inefficient due to noisy, redundant trajectories and long accessibility-tree (AXTree) states. To address both issues, we propose Weasel, a trajectory selection method for offline training of web agents. Weasel selects a fixed-budget subset of trajectory steps by optimizing an objective that balances unary importance with pairwise diversity over states, websites, and interaction patterns, solving efficiently with a greedy algorithm. We further improve efficiency with target-centered AXTree pruning that keeps only content around the ground-truth action target, and we mitigate style mismatch for reasoning-native models by replacing expert traces with model-generated, style-consistent rationales. Across AgentTrek and NNetNav training datasets, evaluations in WebArena, WorkArena, and MiniWob, and experiments with Qwen2.5-7B, Gemma3-4B, and Qwen3-8B, Weasel improves out-of-domain performance while reducing training cost, producing roughly 9.7-12.5$\times$ training speedups over standard fine-tuning. We make the code available at https://github.com/fatemehpesaran310/weasel.

Poster
Evaluating Sample Utility for Efficient Data Selection by Mimicking Model Weights

Tzu-Heng Huang, Manjot Bilkhu, John Cooper, Frederic Sala, Javier Movellan

展开摘要

Large-scale web-crawled datasets contain noise, bias, and irrelevant information, necessitating data selection techniques. Existing methods depend on hand-crafted heuristics, downstream datasets, or require expensive influence-based computations---all of which limit scalability and introduce unwanted data dependencies. To address this, we introduce the Mimic Score, a simple and geometry-based data-quality metric that evaluates utility by measuring alignment between a sample’s gradients and a target direction induced by a pre-trained reference model. This leverages readily available model weights, avoids needing validation datasets, and incurs minimal computational overheads. Building on this metric, we propose Grad-Mimic, a two-stage framework that re-weights samples online to accelerate training and aggregates sample utilities offline to construct effective data filters. Empirically, we show that using mimic scores to guide training improves data efficiency, accelerates convergence, yields consistent performance gains across six image datasets, and enhances CLIP models with 20.7\% fewer training steps. Additionally, mimic score-based filters augment existing filtering techniques, enabling improved CLIP models trained with 4.7 million fewer samples.

Poster
Motion Dynamics Learning for Few-Shot Embodied Adaptation

Sibo He, Weiying Xie, Daixun Li, Junhao Zhong, Jiayun Tian, Yunke Wang, Leyuan Fang, Gang He, Yunsong Li

展开摘要

Vision-Language-Action (VLA) models have shown strong potential for robotic manipulation, yet adapting pretrained models to novel tasks typically relies on substantial task-specific demonstrations, limiting scalability. Current VLA methods mostly focus on action imitation, which ignores the richer structure contained in trajectories. In contrast, motion dynamics governing how actions evolve over time are more informative and transferable, making them better suited for few-shot adaptation. Motivated by this idea, we propose DynVLA, a few-shot adaptation system that reformulates VLA learning from action imitation to trajectory-level motion dynamics modeling. Specifically, we propose Motion Dynamics Mechanism (MDM), which distills latent embeddings from trajectories via flow-matching inversion, yielding compact representations that capture dynamics. We further design Dynamics-Constrained Modeling (DCM). DCM projects these inferred representations onto a Dynamics Bank, which stores prior motion knowledge pretrained from diverse demonstrations. By grounding action generation in these learned priors, the system enables interpolating between existing action paradigms to represent novel dynamics modes. Experiments on 13 real-world tasks demonstrate that DynVLA outperforms existing SOTA systems by 15.8\% in average success rate with around 20 demonstrations, highlighting its adaptation capabilities in real-world scenes. Our code is available at https://github.com/trantor2nd/Motion-DynVLA.

Poster
HyPOLE: Hyperproperty-Guided Multi-Agent Reinforcement Learning under Partial Observation

Arshia Rafieioskouei, Tzu-Han Hsu, Matthew Lucas, Borzoo Bonakdarpour

展开摘要

Formal specification is a powerful tool to guide the learning process and provides significant advantages over reward shaping: (1) mathematical rigor; (2) expressiveness to specify objectives and constraints, and (3) the ability to define tactics to achieve objectives. However, these benefits remain largely unexplored in the context of Multi-Agent Reinforcement Learning (MARL). This paper introduces HyPOLE, a novel framework for MARL under partial observability, where learning is guided by the expressive power of the so-called hyperproperties and, in particular, the temporal logic HyperLTL. We integrate Centralized Training for Decentralized Execution (CTDE) techniques with HyPOLE to synthesize decentralized policies, and our evaluation on SMAC, MessySMAC, and WildFire benchmark demonstrates clear advantages over baselines.

Poster
Bipartite Graph Attention-based Clustering for Large-scale scRNA-seq Data

Zhuomin Liang, Liang Bai, Xian Yang

展开摘要

scRNA-seq clustering is a critical task for analyzing single-cell RNA sequencing (scRNA-seq) data, as it groups cells with similar gene expression profiles. Transformers, as powerful foundational models, have been applied to scRNA-seq clustering. Their self-attention mechanism automatically assigns higher attention weights to cells within the same cluster, enhancing the distinction between clusters. Existing methods for scRNA-seq clustering, such as graph transformer-based models, treat each cell as a token in a sequence. Their computational and space complexities are $\mathcal{O}(n^2)$ with respect to the number of cells, limiting their applicability to large-scale scRNA-seq datasets. To address this challenge, we propose a Bipartite Graph Transformer-based clustering model (BGFormer) for scRNA-seq data. We introduce a set of learnable anchor tokens as shared reference points to represent the entire dataset. A bipartite graph attention mechanism is introduced to learn the similarity between cells and anchor tokens, bringing cells of the same class closer together in the embedding space. BGFormer achieves linear computational complexity with respect to the number of cells, making it scalable to large datasets. Experimental results on multiple large-scale scRNA-seq datasets demonstrate the effectiveness and scalability of BGFormer.

Poster
Lie-Algebraic Acceleration of Neural Koopman Dynamics

Jongwon Lee, Jiwoong Kim, Jungwoo Park, Sungwoo Park

展开摘要

We present a Lie-algebraic approach to model Koopman dynamics that integrates algebraic structure with computational scalability. The proposed formulation constrains the neural generators to evolve within prescribed Lie subalgebras and constructs finite-time flows through a neural Magnus expansion construction, thereby maintaining consistency with the associated Lie-group composition over each time segment. To address the computational burden inherent in sequential propagation, we exploit the associativity of Lie-group compositions and construct segmentwise propagators via a prefix-scan algorithm, which reduces the depth of temporal composition from linear to logarithmic. Consequently, the framework enables accurate long-horizon prediction while improving computational efficiency, and provides a principled foundation for scalable Koopman operator learning for nonlinear systems.

Poster
CoverPruneGS: Coverage-Preserving Structured Pruning for Hierarchical 3D Gaussian Splatting from Sparse-View Monocular Videos

Yang Xiao, Guoan Xu, Guxue Gao, Qiang Wu, Wenjing Jia

展开摘要

Reconstructing complete yet compact 3D Gaussian Splatting (3DGS) representations from sparse-view monocular videos remains a significant challenge. While hierarchical training with Video Frame Interpolation (VFI) improves coverage, its correlated pseudo-views and repeated merging accumulate structured, non-i.i.d. redundancy, violating the implicit independence assumptions of standard pruning methods and rendering global thresholding ineffectual. We propose CoverPruneGS, a coverage-preserving structured pruning framework specifically designed for hierarchical 3DGS. Our approach implements a coarse-to-fine pruning pipeline using voxel-based local diversity selection and ground-truth-guided lazy refinement via randomized dropout rendering. To ensure reliable refinement, we introduce a footprint-aware CUDA attribution mechanism. By aggregating ground-truth-aligned error degradation across Gaussian-influenced pixels, we generate faithful importance scores that enable precise, quantile-based "rescue" of essential primitives. Experimental results across multiple datasets demonstrate that CoverPruneGS substantially reduces Gaussian counts by 56.8\% and significantly accelerates inference speeds, all while enhancing or maintaining the quality of novel view synthesis.

Poster
DART: Distribution-Aware Adaptive Relational Transfer for Adversarial Attacks against Closed-Source MLLMs

Kaidi Hu, Guancheng Wan, Xiao Luo, Ruigang Yang

展开摘要

This paper studies the critical problem of targeted adversarial attacks against closed-source MLLMs, which aim to generate highly transferable adversarial samples with open-source MLLMs. Previous approaches typically focus on maximizing the similarity of latent representations between adversarial samples and target samples. However, these approaches could overfit specific target samples with severely limited generalization ability to closed-source MLLMs. Towards this end, we propose a novel approach named Distribution-aware Adaptive Relational Transfer (DART) for adversarial attacks against closed-source MLLMs. The core of our DART is to adopt a statistical lens to characterize the intrinsic semantics of images for more generalized and robust alignment. In particular, each augmented image is considered an example from the intrinsic distribution of the original image. Then, we utilize non-parametric Energy Distance to measure the distribution divergence, which is naturally adopted for the semantic alignment in the hidden space. To further enhance transferability to specific target models, we learn a graph neural network (GNN) to explore the complex relations between source and target MLLMs on transferability and adaptively select surrogate models to maximize transferability across diverse targets. Extensive experiments on benchmark datasets validate the superior robustness and effectiveness of the proposed DART in comparison to various competing baselines.

Poster
KORE: Enhancing Knowledge Injection for Large Multimodal Models via Knowledge-Oriented Controls

Kailin Jiang, Hongbo Jiang, Ning Jiang, Zhi Gao, Jinhe Bi, Yuchen Ren, Bin Li, Yuntao Du, Lei Liu, Qing Li

展开摘要

Large Multimodal Models encode extensive factual knowledge in their pre-trained weights. However, its knowledge remains static and limited, unable to keep pace with real-world developments, which hinders continuous knowledge acquisition. Effective knowledge injection thus becomes critical, involving two goals: knowledge adaptation (injecting new knowledge) and knowledge retention (preserving old knowledge). Existing methods often struggle to learn new knowledge and suffer from catastrophic forgetting. To address these challenges, we propose KORE, a synergistic method centered around KnOwledge-oRientEd controls. These controls are implemented through a two-stage optimization process: (1) KORE automatically converts individual knowledge items into structured and comprehensive knowledge to ensure that the model accurately learns new knowledge, enabling accurate adaptation. (2) KORE stores previous knowledge in the covariance matrix of LMM's linear layer activations and initializes the adapter by projecting the original weights into the matrix's null space, defining a fine-tuning direction that minimizes interference with previous knowledge, enabling powerful retention. Extensive experiments on various LMMs, including LLaVA-v1.5 (7B), LLaVA-v1.5 (13B), and Qwen2.5-VL (7B), show that KORE achieves superior new knowledge injection performance and effectively mitigates catastrophic forgetting.

Poster
Towards Optimal Robustness in Learning-Augmented Paging

Peng Chen, Hailiang Zhao, Xueyan Tang, Yixuan Wang, Shuiguang Deng

展开摘要

Learning-augmented paging has been extensively studied in recent years. A key advantage over naive ML-based approaches is bounded robustness, which guarantees worst-case performance even when predictions are inaccurate, making these algorithms valuable for real-world systems. Prior work achieves robustness bounds of $2H_k + O(1)$ in the randomized setting, leaving a gap to the optimal competitive ratio $H_k$. In this paper, we study how to close this gap. We begin by reviewing online optimality and proving a new property of the latest $H_k$-competitive algorithm, which facilitates our analysis in the learning-augmented setting. Then, we review existing learning-augmented paging algorithms and introduce a unifying primitive, the relative prediction budget, which captures the essence of establishing robustness and reveals that prior algorithms either overuse or underutilize predictions. Guided by the above analysis, we develop a new framework that achieves the best-possible robustness up to an additive constant for learning-augmented paging: $H_k + O(1)$. Experiments further demonstrate strong practical performance.

Spotlight
WebWorld: A Large-Scale World Model for Web Agent Training

Zikai Xiao, Jianhong Tu, Chuhang Zou, Yuxin Zuo, Zhi Li, Peng Wang, Bowen Yu, Fei Huang, Junyang Lin, Zuozhu Liu

展开摘要

Web agents require massive trajectories to generalize, yet real-world training is constrained by network latency, rate limits, and safety risks. We introduce \textbf{WebWorld} series, the first open-web simulator trained at scale. While existing simulators are restricted to closed environments with thousands of trajectories, WebWorld leverages a scalable data pipeline to train on 1M+ open-web interactions, supporting reasoning, multi-format data, and long-horizon simulations of 30+ steps. For intrinsic evaluation, we introduce WebWorld-Bench with dual metrics spanning nine dimensions, where WebWorld achieves simulation performance comparable to Gemini-3-Pro. For extrinsic evaluation, Qwen3-14B trained on WebWorld-synthesized trajectories improves by +9.2\% on WebArena, reaching performance comparable to GPT-4o. WebWorld enables effective inference-time search, outperforming GPT-5 as a world model. Beyond web simulation, WebWorld exhibits cross-domain generalization to code, GUI, and game environments, providing a replicable recipe for world-model construction.

Poster
CocoRNA: Collective RNA Design with Cooperative Multi-agent Reinforcement Learning

Tianmeng Hu, Biao Luo, Ke Li

展开摘要

Designing RNA sequences that reliably fold into specific secondary structures is essential for understanding their biological functions but remains a challenging computational problem. We propose CocoRNA, a cooperative multi-agent reinforcement learning framework for RNA inverse design. CocoRNA simplifies the design task by decomposing it into smaller sub-problems, each solved collaboratively by multiple agents. This approach reduces the complexity of the problem and improves the exploration of design policies. During training, a centralized critic uses global structural information to guide the agents, enabling them to jointly optimize their design strategies. As a result, CocoRNA learns high-quality RNA design policies that generalize effectively to unseen structures without additional training. Experiments on the Rfam dataset demonstrate that CocoRNA substantially outperforms state-of-the-art methods in both success rate and design speed. Further experiments on other biological sequence design tasks highlight the effectiveness and broad potential of CocoRNA for complex design tasks.

Poster