CVPR 2025 论文列表

Foundation models for interactive segmentation in 2D natural images and videos have sparked significant interest in building 3D foundation models for medical imaging. However, the domain gaps and clinical use cases for 3D medical imaging require a dedicated model that diverges from existing 2D solutions. Specifically, such foundation models should support a full workflow that can actually reduce human effort. Treating 3D medical images as sequences of 2D slices and reusing interactive 2D foundation models seems straightforward, but 2D annotation is too time-consuming for 3D tasks. Moreover, for large cohort analysis, it's the highly accurate automatic segmentation models that reduce the most human effort. However, these models lack support for interactive corrections and lack zero-shot ability for novel structures, which is a key feature of "foundation". While reusing pre-trained 2D backbones in 3D enhances zero-shot potential, their performance on complex 3D structures still lags behind leading 3D models. To address these issues, we present VISTA3D, Versatile Imaging SegmenTation and Annotation model, that targets to solve all thesechallenges and requirements with one unified foundation model. VISTA3D is built on top of the well-established 3D segmentation pipeline, and it is the first model to achieve state-of-the-art performance in both 3D automatic (supporting 127 classes) and 3D interactive segmentation, even when compared with top 3D expert models on large and diverse benchmarks. Additionally, VISTA3D's 3D interactive design allows efficient human correction, and a novel 3D supervoxel method that distills 2D pretrained backbones grants VISTA3D top 3D zero-shot performance. We believe the model, recipe, and insights represent a promising step toward a clinically useful 3D foundation model. Code and weights are publicly available at https://github.com/Project-MONAI/VISTA

The recently emerged in-context-learning-based (ICL-based) models have the potential towards the unification of medical lesion segmentation. However, due to their cross-fusion designs, existing ICL-based unified segmentation models fail to accurately localize lesions with low-matched reference sets. Considering that the query itself can be regarded as a high-matched reference, which better indicates the target, we design a self-referencing mechanism that adaptively extracts self-referring indicator vectors from the query based on coarse predictions, thus effectively overcoming the negative impact caused by low-match reference sets. To further facilitate the self-referring mechanism, we introduce reference indicator generation to efficiently extract reference information for coarse predictions instead of using cross-fusion modules, which heavily rely on reference sets. Our designs successfully address the challenges of applying ICL to unified medical lesion segmentation, forming a novel framework named SR-ICL. Our method achieves state-of-the-art results on 8 medical lesion segmentation tasks with only 4 image-mask pairs as reference. Notably, SR-ICL still accomplishes remarkable performance even when using weak reference annotations such as boxes and points, and maintains fixed and low memory consumption even if more tasks are combined. We hope that SR-ICL can provide new insights for the clinical application of medical lesion segmentation.

Capturing high dynamic range (HDR) scenes is one of the most important issues in camera design. Majority of cameras use exposure fusion, which fuses images captured by different exposure levels, to increase dynamic range. However, this approach can only handle images with limited exposure difference, normally 3-4 stops. When applying to very high dynamic range scenes where a large exposure difference is required, this approach often fails due to incorrect alignment or inconsistent lighting between inputs, or tone mapping artifacts. In this work, we propose UltraFusion, the first exposure fusion technique that can merge inputs with 9 stops differences. The key idea is that we model exposure fusion as a guided inpainting problem, where the under-exposed image is used as a guidance to fill the missing information of over-exposed highlights in the over-exposed region. Using an under-exposed image as a soft guidance, instead of a hard constraint, our model is robust to potential alignment issue or lighting variations. Moreover, by utilizing the image prior of the generative model, our model also generates natural tone mapping, even for very high-dynamic range scenes. Our approach outperforms HDR-Transformer on latest HDR benchmarks. Moreover, to test its performance in ultra high dynamic range scenes, we capture a new real-world exposure fusion benchmark, UltraFusion dataset, with exposure differences up to 9 stops, and experiments show that UltraFusion can generate beautiful and high-quality fusion results under various scenarios. Code and data will be available at https://openimaginglab.github.io/UltraFusion.

Medical image re-identification (MedReID) is under-explored so far, despite its critical applications in personalized healthcare and privacy protection.In this paper, we introduce a thorough benchmark and a unified model for this problem.First, to handle various medical modalities, we propose a novel Continuous Modality-based Parameter Adapter (ComPA). ComPA condenses medical content into a continuous modality representation and dynamically adjusts the modality-agnostic model with modality-specific parameters at runtime. This allows a single model to adaptively learn and process diverse modality data.Furthermore, we integrate medical priors into our model by aligning it with a bag of pre-trained medical foundation models, in terms of the differential features.Compared to single-image feature, modeling the inter-image difference better fits the re-identification problem, which involves discriminating multiple images.We evaluate the proposed model against 25 foundation models and 8 large multi-modal language models across 11 image datasets, demonstrating consistently superior performance.Additionally, we deploy the proposed MedReID technique to two real-world applications, i.e., history-augmented personalized diagnosis and medical privacy protection.

Medical image segmentation remains challenging due to the vast diversity of anatomical structures, imaging modalities, and segmentation tasks. While deep learning has made significant advances, current approaches struggle to generalize as they require task-specific training or fine-tuning on unseen classes. We present Iris, a novel In-context Reference Image guided Segmentation framework that enables flexible adaptation to novel tasks through the use of reference examples without fine-tuning. At its core, Iris features a lightweight context task encoding module that distills task-specific information from reference context image-label pairs. This rich context embedding information is used to guide the segmentation of target objects. Given a decoupled architecture on 3D data processing, Iris supports diverse inference strategies including one-shot inference, context example ensemble, object-level context example retrieval, and in-context tuning. Through comprehensive evaluation across twelve datasets, we demonstrate that Iris performs strongly compared to specialized supervised models on in-distribution tasks. On seven held-out dataset, Iris shows superior generalization to out-of-distribution data and unseen classes. Further, Iris's task encoding module can automatically discover anatomical relationships across datasets and modalities, offering insights into cross-modality medical objects without explicit anatomical supervision.

Deep learning-based image registration methods have shown state-of-the-art performance and rapid inference speeds. Despite these advances, many existing approaches fall short in capturing spatially varying information in non-local regions of feature maps due to the reliance on spatially-shared convolution kernels. This limitation leads to suboptimal estimation of deformation fields. In this paper, we propose a 3D Spatial-Awareness Convolution Block (SACB) to enhance the spatial information within feature representations. Our SACB estimates the spatial clusters within feature maps by leveraging feature similarity and subsequently parameterizes the adaptive convolution kernels across diverse regions. This adaptive mechanism generates the convolution kernels (weights and biases) tailored to spatial variations, thereby enabling the network to effectively capture spatially varying information. Building on SACB, we introduce a pyramid flow estimator (named SACB-Net) that integrates SACBs to facilitate multi-scale flow composition, particularly addressing large deformations. Experimental results on the brain IXI and LPBA datasets as well as Abdomen CT datasets demonstrate the effectiveness of SACB and the superiority of SACB-Net over the state-of-the-art learning-based registration methods. The code is available at https://github.com/x-xc/SACB_Net.

Self-Supervised Learning (SSL) presents an exciting opportunity to unlock the potential of vast, untapped clinical datasets, for various downstream applications that suffer from the scarcity of labeled data. While SSL has revolutionized fields like natural language processing and computer vision, its adoption in 3D medical image computing has been limited by three key pitfalls: Small pre-training dataset sizes, architectures inadequate for 3D medical image analysis, and insufficient evaluation practices. In this paper, we address these issues by i) leveraging a large-scale dataset of 39k 3D brain MRI volumes and ii) using a Residual Encoder U-Net architecture within the state-of-the-art nnU-Net framework. iii) A robust development framework, incorporating 5 development and 8 testing brain MRI segmentation datasets, allowed performance-driven design decisions to optimize the simple concept of Masked Auto En- coders (MAEs) for 3D CNNs. The resulting model not only surpasses previous SSL methods but also outperforms the strong nnU-Net baseline by an average of approximately 3 Dice points setting a new state-of-the-art. Our code and models are made available here.

Deep-unrolling and plug-and-play (PnP) approaches have become the de-facto standard solvers for single-pixel imaging (SPI) inverse problem. PnP approaches, a class of iterative algorithms where regularization is implicitly performed by an off-the-shelf deep denoiser, are flexible for varying compression ratios (CRs) but are limited in reconstruction accuracy and speed. Conversely, unrolling approaches, a class of multi-stage neural networks where a truncated iterative optimization process is transformed into an end-to-end trainable network, typically achieve better accuracy with faster inference but require fine-tuning or even retraining when CR changes. In this paper, we address the challenge of integrating the strengths of both classes of solvers. To this end, we design an efficient deep image restorer (DIR) for the unrolling of HQS (half quadratic splitting) and ADMM (alternating direction method of multipliers). More importantly, a general proximal trajectory (PT) loss function is proposed to train HQS/ADMM-unrolling networks such that learned DIR approximates the proximal operator of an ideal explicit restoration regularizer. Extensive experiments demonstrate that, the resulting proximal unrolling networks can not only flexibly handle varying CRs with a single model like PnP algorithms, but also outperform previous CR-specific unrolling networks in both reconstruction accuracy and speed. Source codes and models are available at https://github.com/pwangcs/ProxUnroll.

Reflection removal is challenging due to complex light interactions, where reflections obscure important details and hinder scene understanding. Polarization naturally provides a powerful cue to distinguish between reflected and transmitted light, enabling more accurate reflection removal. However, existing methods often rely on small-scale or synthetic datasets, which fail to capture the diversity and complexity of real-world scenarios. To this end, we construct a large-scale dataset, PolaRGB, for Polarization-based reflection removal of RGB images, which enables us to train models that generalize effectively across a wide range of real-world scenarios. The PolaRGB dataset contains 6,500 well-aligned mixed-transmission image pairs, 8xlarger than existing polarization datasets, and is the first to include both RGB and polarization images captured across diverse indoor and outdoor environments with varying lighting conditions. Besides, to fully exploit the potential of polarization cues for reflection removal, we introduce PolarFree, which leverages diffusion process to generate reflection-free cues for accurate reflection removal. Extensive experiments show that PolarFree significantly enhances image clarity in challenging reflective scenarios, setting a new benchmark for polarized imaging and reflection removal. Code and dataset are available at https://github.com/mdyao/PolarFree.

Optical imaging capable of resolving nanoscale features would revolutionize scientific research and engineering applications across biomedicine, smart manufacturing, and semiconductor quality control. However, due to the physical phenomenon of diffraction, the optical resolution is limited to approximately half the wavelength of light, which impedes the observation of subwavelength objects such as the native state coronavirus, typically smaller than 200 nm. Fortunately, deep learning methods have shown remarkable potential in uncovering underlying patterns within data, promising to overcome the diffraction limit by revealing the mapping pattern between diffraction images and their corresponding ground truth object images. However, the absence of suitable datasets has hindered progress in this field--collecting high-quality optical data of subwavelength objects is highly difficult as these objects are inherently invisible under conventional microscopy, making it impossible to perform standard visual calibration and drift correction. Therefore, we provide the first general optical imaging dataset based on the "building block" concept for challenging the diffraction limit. Drawing an analogy to modular construction principles, we construct a comprehensive optical imaging dataset comprising subwavelength fundamental elements, i.e., small square units that can be assembled into larger and more complex objects. We then frame the task as an image-to-image translation task and evaluate various vision methods. Experimental results validate our "building block" concept, demonstrating that models trained on basic square units can effectively generalize to realistic, more complex unseen objects. Most importantly, by highlighting this underexplored AI-for-science area and its potential, we aspire to advance optical science by fostering collaboration with the vision and machine learning communities.

The growing reliance on Artificial Intelligence (AI) in critical domains such as healthcare demands robust mechanisms to ensure the trustworthiness of these systems, especially when faced with unexpected or anomalous inputs. This paper introduces the Open Medical Imaging Benchmarks for Out-Of-Distribution Detection (OpenMIBOOD), a comprehensive framework for evaluating out-of-distribution (OOD) detection methods specifically in medical imaging contexts. OpenMIBOOD includes three benchmarks from diverse medical domains, encompassing 14 datasets divided into covariate-shifted in-distribution, near-OOD, and far-OOD categories. We evaluate 24 post-hoc methods across these benchmarks, providing a standardized reference to advance the development and fair comparison of OOD detection methods. Results reveal that findings from broad-scale OOD benchmarks in natural image domains do not translate to medical applications, underscoring the critical need for such benchmarks in the medical field. By mitigating the risk of exposing AI models to inputs outside their training distribution, OpenMIBOOD aims to support the advancement of reliable and trustworthy AI systems in healthcare. The repository is available at https://github.com/remic-othr/OpenMIBOOD.

Neural Radiance Fields (NeRF) have shown impressive performances in the rendering of 3D scenes from arbitrary viewpoints. While RGB images are widely preferred for training volume rendering models, the interest in other radiance modalities is also growing. However, the capability of the underlying implicit neural models to learn and transfer information across heterogeneous imaging modalities has seldom been explored, mostly due to the limited training data availability. For this purpose, we present MultimodalStudio (MMS): it encompasses MMS-DATA and MMS-FW. MMS-DATA is a multimodal multi-view dataset containing 32 scenes acquired with 5 different imaging modalities: RGB, monochrome, near-infrared, polarization and multispectral. MMS-FW is a novel modular multimodal NeRF framework designed to handle multimodal raw data and able to support an arbitrary number of multi-channel devices. Through extensive experiments, we demonstrate that MMS-FW trained on MMS-DATA can transfer information between different imaging modalities and produce higher quality renderings than using single modalities alone. We publicly release the dataset and the framework, to promote the research on multimodal volume rendering and beyond.

Self-supervised learning has greatly facilitated medical image analysis by suppressing the training data requirement for real-world applications. Current paradigms predominantly rely on self-supervision within uni-modal image data, thereby neglecting the inter-modal correlations essential for effective learning of cross-modal image representations. This limitation is particularly significant for naturally grouped multi-modal data, e.g., multi-parametric MRI scans for a patient undergoing various functional imaging protocols in the same study. To bridge this gap, we conduct a novel multi-modal image pre-training with three proxy tasks to facilitate the learning of cross-modality representations and correlations using multi-modal brain MRI scans (over 2.4 million images in 16,022 scans of 3,755 patients), i.e., cross-modal image reconstruction, modality-aware contrastive learning, and modality template distillation. To demonstrate the generalizability of our pre-trained model, we conduct extensive experiments on various benchmarks with ten downstream tasks. The superior performance of our method is reported in comparison to state-of-the-art pre-training methods, with Dice Score improvement of 0.28%-14.47% across six segmentation benchmarks and a consistent accuracy boost of 0.65%-18.07% in four individual image classification tasks.

Recent advances in medical AI have shown a clear trend towards large models in healthcare. However, developing large models for multi-modal medical diagnosis remains challenging due to a lack of sufficient modal-complete medical data. Most existing multi-modal diagnostic models are relatively small and struggle with limited feature extraction capabilities. To bridge this gap, we propose **AdaCoMed**, an **ada**ptive **co**llaborative-learning framework that synergistically integrates the off-the-shelf **med**ical single-modal large models with multi-modal small models. Our framework first employs a mixture-of-modality-experts (MoME) architecture to combine features extracted from multiple single-modal medical large models, and then introduces a novel adaptive co-learning mechanism to collaborate with a multi-modal small model. This co-learning mechanism, guided by an adaptive weighting strategy, dynamically balances the complementary strengths between the MoME-fused large model features and the cross-modal reasoning capabilities of the small model. Extensive experiments on two representative multi-modal medical datasets (MIMIC-IV-MM and MMIST ccRCC) across six modalities and four diagnostic tasks demonstrate consistent improvements over state-of-the-art baselines, making it a promising solution for real-world medical diagnosis applications.

In this work, we present LesionLocator, a framework for zero-shot longitudinal lesion tracking and segmentation in 3D medical imaging, establishing the first end-to-end model capable of 4D tracking with dense spatial prompts. Our model leverages an extensive dataset of 23,262 annotated medical scans, as well as synthesized longitudinal data across diverse lesion types. The diversity and scale of our dataset significantly enhances model generalizability to real-world medical imaging challenges and addresses key limitations in longitudinal data availability. LesionLocator outperforms all existing promptable models in lesion segmentation by nearly 10 dice points, reaching human-level performance, and achieves state-of-the-art results in lesion tracking, with superior lesion retrieval and segmentation accuracy. LesionLocator not only sets a new benchmark in universal promptable lesion segmentation and automated longitudinal lesion tracking but also provides the first open-access solution of its kind, releasing our synthetic 4D dataset and model to the community, empowering future advancements in medical imaging. Code is available at: www.github.com/MIC-DKFZ/LesionLocator

Extracting high-fidelity RGBD information from two-dimensional (2D) images is essential for various visual computing applications. Stereo imaging, as a reliable passive imaging technique for obtaining three-dimensional (3D) scene information, has benefited greatly from deep learning advancements. However, existing stereo depth estimation algorithms struggle to perceive high-frequency information and resolve high-resolution depth maps in realistic camera settings with large depth variations. These algorithms commonly neglect the hardware parameter configuration, limiting the potential for achieving optimal solutions solely through software-based design strategies.This work presents a hardware-software co-designed RGBD imaging framework that leverages both stereo and focus cues to reconstruct texture-rich color images along with detailed depth maps over a wide depth range. A pair of rank-2 parameterized diffractive optical elements (DOEs) is employed to encode perpendicular complementary information optically during stereo acquisitions. Additionally, we employ an IGEV-UNet-fused neural network tailored to the proposed rank-2 encoding for stereo matching and image reconstruction. Through prototyping a stereo camera with customized DOEs, our deep stereo imaging paradigm has demonstrated superior performance over existing monocular and stereo imaging systems in both image PSNR by 2.96 dB gain and depth accuracy in high-frequency details across distances from 0.67 to 8 meters.

Digital imaging systems have traditionally relied on brute-force measurement and processing of pixels arranged on regular grids. In contrast, the human visual system performs significant data reduction from the large number of photoreceptors to the optic nerve, effectively encoding visual information into a low-bandwidth latent space representation optimized for brain processing. Inspired by this, we propose a similar approach to advance artificial vision systems. Latent Space Imaging introduces a new paradigm that combines optics and software to encode image information directly into the semantically rich latent space of a generative model. This approach substantially reduces bandwidth and memory demands during image capture and enables a range of downstream tasks focused on the latent space.We validate this principle through an initial hardware prototype based on a single-pixel camera. By implementing an amplitude modulation scheme that encodes into the generative model's latent space, we achieve compression ratios ranging from 1:100 to 1:1000 during imaging, and up to 1:16384 for downstream applications. This approach leverages the model's intrinsic linear boundaries, demonstrating the potential of latent space imaging for highly efficient imaging hardware, adaptable future applications in high-speed imaging, and task-specific cameras with significantly reduced hardware complexity.

Scaling by training on large datasets has been shown to enhance the quality and fidelity of image generation and manipulation with diffusion models; however, such large datasets are not always accessible in medical imaging due to cost and privacy issues, which contradicts one of the main applications of such models to produce synthetic samples where real data is scarce. Also, finetuning on pre-trained general models has been a challenge due to the distribution shift between the medical domain and the pre-trained models. Here, we propose Latent Drift (LD) for diffusion models that can be adopted for any fine-tuning method to mitigate the issues faced by the distribution shift or employed in inference time as a condition. Latent Drifting enables diffusion models to be conditioned for medical images fitted for the complex task of counterfactual image generation, which is crucial to investigate how parameters such as gender, age, and adding or removing diseases in a patient would alter the medical images. We evaluate our method on three public longitudinal benchmark datasets of brain MRI and chest X-rays for counterfactual image generation. Our results demonstrate significant performance gains in various scenarios when combined with different fine-tuning schemes. The source code of this work is available on GitHub.

The ability to interpret and intervene model decisions is important for the adoption of computer-aided diagnosis methods in clinical workflows. Recent concept-based methods link the model predictions with interpretable concepts and modify their activation scores to interact with the model. However, these concepts are at the image level, which hinders the model from pinpointing the exact patches the concepts are activated. Alternatively, prototype-based methods learn representations from training image patches and compare these with test image patches, using the similarity scores for final class prediction. However, interpreting the underlying concepts of these patches can be challenging and often necessitates post-hoc guesswork. To address this issue, this paper introduces the novel Concept-based Similarity Reasoning network (CSR), which offers (i) patch-level prototype with intrinsic concept interpretation, and (ii) spatial interactivity. First, the proposed CSR provides localized explanation by grounding prototypes of each concept on image regions. Second, our model introduces novel spatial-level interaction, allowing doctors to engage directly with specific image areas, making it an intuitive and transparent tool for medical imaging. CSR improves upon prior state-of-the-art interpretable methods by up to 4.% across three biomedical datasets.