NeurIPS 2024 论文列表

Conference on Neural Information Processing Systems

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4,562篇论文

按官方录用论文列表统计,可能与会议公布的数字略有出入。

  • Oral
    721.6%
  • Spotlight
    3828.4%
  • Poster
    4,06489.1%
  • 其他 / 未标注
    441.0%

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DisCEdit: Model Editing by Identifying Discriminative Components

Chaitanya Murti, Chiranjib Bhattacharyya

展开摘要

Model editing is a growing area of research that is particularly valuable in contexts where modifying key model components, like neurons or filters, can significantly impact the model’s performance. The key challenge lies in identifying important components useful to the model’s predictions. We apply model editing to address two active areas of research, Structured Pruning, and Selective Class Forgetting. In this work, we adopt a distributional approach to the problem of identifying important components, leveraging the recently proposed discriminative filters hypothesis, which states that well-trained (convolutional) models possess discriminative filters that are essential to prediction. To do so, we define discriminative ability in terms of the Bayes error rate associated with the feature distributions, which is equivalent to computing the Total Variation (TV) distance between the distributions. However, computing the TV distance is intractable, motivating us to derive novel witness function-based lower bounds on the TV distance that require no assumptions on the underlying distributions; using this bound generalizes prior work such as Murti et al. [39] that relied on unrealistic Gaussianity assumptions on the feature distributions. With these bounds, we are able to discover critical subnetworks responsible for classwise predictions, and derive DISCEDIT-SP and DISCEDIT-U , algorithms for structured pruning requiring no access to the training data and loss function, and selective forgetting respectively. We apply DISCEDIT-U to selective class forgetting on models trained on CIFAR10 and CIFAR100, and we show that on average, we can reduce accuracy on a single class by over 80% with a minimal reduction in test accuracy on the remaining classes. Similarly, on Structured pruning problems, we obtain 40.8% sparsity on ResNet50 on Imagenet, with only a 2.6% drop in accuracy with minimal fine-tuning.

Poster
Absorb & Escape: Overcoming Single Model Limitations in Generating Heterogeneous Genomic Sequences

Zehui Li, Yuhao Ni, Guoxuan Xia, William Beardall, Akashaditya Das, Guy-Bart Stan, Yiren Zhao

展开摘要

Recent advances in immunology and synthetic biology have accelerated the development of deep generative methods for DNA sequence design. Two dominant approaches in this field are AutoRegressive (AR) models and Diffusion Models (DMs). However, genomic sequences are functionally heterogeneous, consisting of multiple connected regions (e.g., Promoter Regions, Exons, and Introns) where elements within each region come from the same probability distribution, but the overall sequence is non-homogeneous. This heterogeneous nature presents challenges for a single model to accurately generate genomic sequences. In this paper, we analyze the properties of AR models and DMs in heterogeneous genomic sequence generation, pointing out crucial limitations in both methods: (i) AR models capture the underlying distribution of data by factorizing and learning the transition probability but fail to capture the global property of DNA sequences. (ii) DMs learn to recover the global distribution but tend to produce errors at the base pair level. To overcome the limitations of both approaches, we propose a post-training sampling method, termed Absorb & Escape (A&E) to perform compositional generation from AR models and DMs. This approach starts with samples generated by DMs and refines the sample quality using an AR model through the alternation of the Absorb and Escape steps. To assess the quality of generated sequences, we conduct extensive experiments on 15 species for conditional and unconditional DNA generation. The experiment results from motif distribution, diversity checks, and genome integration tests unequivocally show that A&E outperforms state-of-the-art AR models and DMs in genomic sequence generation. A&E does not suffer from the slowness of traditional MCMC to sample from composed distributions with Energy-Based Models whilst it obtains higher quality samples than single models. Our research sheds light on the limitations of current single-model approaches in DNA generation and provides a simple but effective solution for heterogeneous sequence generation. Code is available at the [Github Repo](https://github.com/Zehui127/Absorb-Escape).

Poster
Model Decides How to Tokenize: Adaptive DNA Sequence Tokenization with MxDNA

Lifeng Qiao, Peng Ye, Yuchen Ren, Weiqiang Bai, chaoqi liang, Xinzhu Ma, Nanqing Dong, Wanli Ouyang

展开摘要

Foundation models have made significant strides in understanding the genomic language of DNA sequences. However, previous models typically adopt the tokenization methods designed for natural language, which are unsuitable for DNA sequences due to their unique characteristics. In addition, the optimal approach to tokenize DNA remains largely under-explored, and may not be intuitively understood by humans even if discovered. To address these challenges, we introduce MxDNA, a novel framework where the model autonomously learns an effective DNA tokenization strategy through gradient decent. MxDNA employs a sparse Mixture of Convolution Experts coupled with a deformable convolution to model the tokenization process, with the discontinuous, overlapping, and ambiguous nature of meaningful genomic segments explicitly considered. On Nucleotide Transformer Benchmarks and Genomic Benchmarks, MxDNA demonstrates superior performance to existing methods with less pretraining data and time, highlighting its effectiveness. Finally, we show that MxDNA learns unique tokenization strategy distinct to those of previous methods and captures genomic functionalities at a token level during self-supervised pretraining. Our MxDNA aims to provide a new perspective on DNA tokenization, potentially offering broad applications in various domains and yielding profound insights. Code is available at https://github.com/qiaoqiaoLF/MxDNA.

Poster