ICML 2025 论文列表

International Conference on Machine Learning

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3,342篇论文

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  • Spotlight
    2256.7%
  • Poster
    2,99689.6%

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EEG-Language Pretraining for Highly Label-Efficient Clinical Phenotyping

Sam Gijsen, Kerstin Ritter

展开摘要

Multimodal language modeling has enabled breakthroughs for representation learning, yet remains unexplored in the realm of functional brain data for clinical phenotyping. This paper pioneers EEG-language models (ELMs) trained on clinical reports and 15000 EEGs. We propose to combine multimodal alignment in this novel domain with timeseries cropping and text segmentation, enabling an extension based on multiple instance learning to alleviate misalignment between irrelevant EEG or text segments. Our multimodal models significantly improve over EEG-only models across four clinical evaluations and for the first time enable zero-shot classification as well as retrieval of both neural signals and reports. In sum, these results highlight the potential of ELMs, representing significant progress for clinical applications.

Poster
Doubly Protected Estimation for Survival Outcomes Utilizing External Controls for Randomized Clinical Trials

Chenyin Gao, Shu Yang, Mingyang Shan, Wenyu Ye, Ilya Lipkovich, Douglas Faries

展开摘要

Censored survival data are common in clinical trials, but small control groups can pose challenges, particularly in rare diseases or where balanced randomization is impractical. Recent approaches leverage external controls from historical studies or real-world data to strengthen treatment evaluation for survival outcomes. However, using external controls directly may introduce biases due to data heterogeneity. We propose a doubly protected estimator for the treatment-specific restricted mean survival time difference that is more efficient than trial-only estimators and mitigates biases from external data. Our method adjusts for covariate shifts via doubly robust estimation and addresses outcome drift using the DR-Learner for selective borrowing. The approach can incorporate machine learning to approximate survival curves and detect outcome drifts without strict parametric assumptions, borrowing only comparable external controls. Extensive simulation studies and a real-data application evaluating the efficacy of Galcanezumab in mitigating migraine headaches have been conducted to illustrate the effectiveness of our proposed framework.

Poster