CVPR 2026 论文列表

Conference on Computer Vision and Pattern Recognition

录用类型

4,042篇论文

按官方录用论文列表统计,可能与会议公布的数字略有出入。

  • Oral
    1383.4%
  • Poster
    3,90496.6%

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UniTEX: Universal High Fidelity Generative Texturing for 3D Shapes

Yixun Liang, Kunming Luo, Xiao Chen, Rui Chen, Hongyu Yan, Weiyu Li, Jiarui Liu, Fei-Peng Tian, Ping Tan

展开摘要

We present UniTEX, a novel two-stage 3D texture generation framework to create high-quality, consistent textures for 3D assets. Existing approaches predominantly rely on UV-based models in the second stage to refine textures after reprojecting the generated multi-view images onto the 3D shapes, which introduces challenges related to topological ambiguity. To address this, we bypass the limitations of UV mapping by introducing a Large Texturing Model (LTM) that directly regresses textures in a unified 3D functional space. Moreover, to enable more effective and complete supervision of LTM, we propose to extend surface-defined textures into a continuous volumetric field to serve as an advanced training objective, which we refer to as Texture Functions (TF). Finally, we develop an advanced LoRA-based strategy for efficiently adapting large-scale 2D Diffusion Transformers (DiTs) for high-quality multi-view texture synthesis as our first stage. Extensive experiments demonstrate that UniTEX achieves superior visual quality and texture integrity compared to existing approaches, offering a generalizable and scalable solution for automated 3D texture generation. Code is available in: https://github.com/HKUST-SAIL/UniTEX

Poster
gQIR: Generative Quanta Image Reconstruction

Aryan Garg, Sizhuo Ma, Mohit Gupta

展开摘要

Capturing high-quality images from only a few detected photons is a fundamental challenge in computational imaging. Single-photon avalanche diode (SPAD) sensors promise high-quality imaging in regimes where conventional cameras fail, but raw quanta frames contain only sparse, noisy, binary photon detections. Recovering a coherent image from a burst of such frames requires handling alignment, denoising, and demosaicing (for color) under noise statistics far outside those assumed by standard restoration pipelines or modern generative models. We present an approach that adapts large text-to-image latent diffusion models to the photon-limited domain of quanta burst imaging. Our method leverages the structural and semantic priors of internet-scale diffusion models while introducing mechanisms to handle Bernoulli photon statistics. By integrating latent-space restoration with burst-level spatio-temporal reasoning, our approach produces reconstructions that are both photometrically faithful and perceptually pleasing, even under high-speed motion. We evaluate the method on synthetic benchmarks and new real-world datasets, including the first color SPAD burst dataset and a challenging Deforming (XD) video benchmark. Across all settings, the approach substantially improves perceptual quality over classical and modern learning-based baselines, demonstrating the promise of adapting large generative priors to extreme photon-limited sensing. Code at https://github.com/Aryan-Garg/gQIR.

Poster
Residual Connections Harm Generative Representation Learning

Xiao Zhang, Ruoxi Jiang, William Gao, Rebecca Willet, Michael Maire

展开摘要

We show that introducing a weighting factor to reduce the influence of identity shortcuts in residual networks significantly enhances semantic feature learning in generative representation learning frameworks, such as masked autoencoders (MAEs) and diffusion models. Our modification improves linear probing accuracy for both, notably increasing ImageNet accuracy from 67.8% to 72.7% for MAEs with a VIT-B/16 backbone, while also boosting generation quality for diffusion models. This significant gap suggests that, while residual connection structure serves an essential role in facilitating gradient propagation, it may have a harmful side effect of reducing capacity for abstract learning by virtue of injecting an echo of shallower representations into deeper layers. We ameliorate this downside via a fixed formula for monotonically decreasing the contribution of identity connections as layer depth increases. Our design promotes the gradual development of feature abstractions, without impacting network trainability. Analyzing the representations learned by our modified residual networks, we find correlation between low effective feature rank and downstream task performance.

Poster
Bridging Facial Understanding and Animation via Language Models

Luchuan Song, Pinxin Liu, Haiyang Liu, Zhenchao Jin, Yolo Yunlong Tang, Zichong Xu, Susan Liang, Jing Bi, Jason J. Corso, Chenliang Xu

展开摘要

Text-guided human body animation has advanced rapidly, yet facial animation lags due to the scarcity of well-annotated, text-paired facial corpora. To close this gap, we leverage foundation generative models to synthesize a large, balanced corpus of facial behavior. We design prompts suite covering emotions and head motions, generate about 80 hours of facial videos with multiple generators, and fit per-frame 3D facial parameters, yielding large-scale (prompt and parameter) pairs for training. Building on this dataset, we probe language models for bidirectional competence over facial motion via two complementary tasks: (1) Motion2Language: given a sequence of 3D facial parameters, the model produces natural-language descriptions capturing content, style, and dynamics; and (2) Language2Motion: given a prompt, the model synthesizes the corresponding sequence of 3D facial parameters via quantized motion tokens for downstream animation. Extensive experiments show that in this setting language models can both interpret and synthesize facial motion with strong generalization. To best of our knowledge, this is the first work to cast facial-parameter modeling as a language problem, establishing a unified path for text-conditioned facial animation and motion understanding.

Poster
DualPrim: Compact 3D Reconstruction with Positive and Negative Primitives

Xiaoxu Meng, Zhongmin Chen, Bo Yang, Weikai Chen, Weixiao Liu, Lin Gao

展开摘要

We present Compact 3D Reconstruction with Positive and Negative Primitives (DualPrim), a novel approach for reconstructing compact and topologically regular 3D meshes from multi-view images. Unlike traditional methods that rely on implicit representations such as signed distance functions, or explicit formats such as meshes and point clouds, our method models geometry using quadrics-based 3D primitives. Each primitive is defined by a positive-density superquadric that contributes to the shape, and a negative-density superquadric that carves out local volumes, enabling fine-grained geometric control and flexible topology. This dual-primitive representation yields compact, well-regularized, and efficiently parameterized mesh reconstructions. To infer primitive parameters from multi-view images, we design a differentiable rendering pipeline that jointly estimates positive and negative superquadrics under view-consistent supervision. Extensive experiments demonstrate that DualPrim outperforms state-of-the-art methods in reconstruction accuracy while producing more geometrically concise, interpretable, and high-fidelity 3D meshes.

Poster
POLAR: A Portrait OLAT Dataset and Generative Framework for Illumination-Aware Face Modeling

Zhuo Chen, Chengqun Yang, Zhuo Su, Zheng Lv, Jingnan Gao, Xiaoyuan Zhang, Xiaokang Yang, Yichao Yan

展开摘要

Face relighting aims to synthesize realistic portraits under novel illumination while preserving identity and geometry. However, progress remains constrained by the limited availability of large-scale, physically consistent illumination data. To address this, we introduce POLAR, a large-scale and physically calibrated One-Light-at-a-Time (OLAT) dataset containing over 200 subjects captured under 156 lighting directions, multiple views, and diverse expressions. Building upon POLAR, we develop a flow-based generative model POLARNet that predicts per-light OLAT responses from a single portrait, capturing fine-grained and direction-aware illumination effects while preserving facial identity. Unlike diffusion or background-conditioned methods that rely on statistical or contextual cues, our formulation models illumination as a continuous, physically interpretable transformation between lighting states, enabling scalable and controllable relighting. Together, POLAR and POLARNet form a unified illumination learning framework that links real data, generative synthesis, and physically grounded relighting, establishing a self-sustaining "chicken-and-egg" cycle for scalable and reproducible portrait illumination.

Oral
Generating Humanless Environment Walkthroughs from Egocentric Walking Tour Videos

Yujin Ham, Junho Kim, Vivek Boominathan, Guha Balakrishnan

展开摘要

Egocentric walking tour videos provide a rich source of image data to develop rich and diverse visual models of environments around the world. However, the significant presence of humans in frames of these videos due to crowds and eye-level camera perspectives mitigates their usefulness in environment modeling applications. We focus on addressing this challenge by developing a generative algorithm that can realistically remove (i.e., inpaint) humans and their associated shadow effects from walking tour videos. Key to our approach is the construction of a rich semi-synthetic dataset of video clip pairs to train this generative model. Each pair in the dataset consists of an environment-only background clip, and a composite clip of walking humans with simulated shadows overlaid on the background. We randomly sourced both foreground and background components from real egocentric walking tour videos around the world to maintain visual diversity. We then used this dataset to fine-tune the state-of-the-art Casper video diffusion model for object and effects inpainting, and demonstrate that the resulting model performs far better than Casper both qualitatively and quantitatively at removing humans from walking tour clips with significant human presence and complex backgrounds. Finally, we show that the resulting generated clips can be used to build successful 3D/4D models of urban locations.

Poster
Improved Mean Flows: On the Challenges of Fastforward Generative Models

Zhengyang Geng, Yiyang Lu, Zongze Wu, Eli Shechtman, J Zico Kolter, Kaiming He

展开摘要

MeanFlow (MF) has recently been established as a framework for one-step generative modeling. However, its "fastforward" nature introduces key challenges in both the training objective and the guidance mechanism. First, the original MF's training target depends not only on the underlying ground-truth fields but also on the network itself. To address this issue, we recast the objective as a loss on the instantaneous velocity v, re-parameterized by a network that predicts the average velocity u. Our reformulation yields a more standard regression problem and improves the training stability. Second, the original MF fixes the classifier-free guidance scale during training, which sacrifices flexibility. We tackle this issue by formulating guidance as explicit conditioning variables, thereby retaining flexibility at test time. The diverse conditions are processed through in-context conditioning, which reduces model size and benefits performance. Overall, our improved MeanFlow (iMF) method, trained entirely from scratch, achieves 1.72 FID with a single function evaluation (1-NFE) on ImageNet 256x256. iMF substantially outperforms prior methods of this kind and closes the gap with multi-step methods while using no distillation. We hope our work will further advance fastforward generative modeling as a stand-alone paradigm.

Poster
TAG-MoE: Task-Aware Gating for Unified Generative Mixture-of-Experts

Yu Xu, Hongbin Yan, Juan Cao, Yiji Cheng, Tiankai Hang, Runze He, Zijin Yin, Shiyi Zhang, Yuxin Zhang, Jintao Li, Chunyu Wang, Qinglin Lu, Tong-Yee Lee, Fan Tang

展开摘要

Unified image generation and editing models suffer from severe task interference in dense diffusion transformers architectures, where a shared parameter space must compromise between conflicting objectives (e.g., local editing v.s. subject-driven generation). While the sparse Mixture-of-Experts (MoE) paradigm is a promising solution, its gating networks remain task-agnostic, operating based on local features, unaware of global task intent. This task-agnostic nature prevents meaningful specialization and fails to resolve the underlying task interference.In this paper, we propose a novel framework to inject semantic intent into MoE routing. We introduce a Hierarchical Task Semantic Annotation scheme to create structured task descriptors (e.g., scope, type, preservation). We then design Predictive Alignment Regularization to align internal routing decisions with the task's high-level semantics. This regularization evolves the gating network from a task-agnostic executor to a dispatch center. Our model effectively mitigates task interference, outperforming dense baselines in fidelity and quality, and our analysis shows that experts naturally develop clear and semantically correlated specializations.

Poster
Generative Adversarial Perturbations with Cross-paradigm Transferability on Localized Crowd Counting

Alabi Mehzabin Anisha, Guangjing Wang, Sriram Chellappan

展开摘要

State-of-the-art crowd counting and localization are primarily modeled using two paradigms: density maps and point regression. Given the field's security ramifications, there is active interest in model robustness against adversarial attacks. Recent studies have demonstrated transferability across density-map-based approaches via adversarial patches, but cross-paradigm attacks (i.e., across both density map-based models and point regression-based models) remain unexplored. We introduce a novel adversarial framework that compromises both density map and point regression architectural paradigms through a comprehensive multi-task loss optimization. For point-regression models, we employ scene-density-specific high-confidence logit suppression; for density-map approaches, we use peak-targeted density map suppression. Both are combined with model-agnostic perceptual constraints to ensure that perturbations are effective and imperceptible to the human eye. Extensive experiments demonstrate the effectiveness of our attack, achieving on average a 7X increase in Mean Absolute Error compared to clean images while maintaining competitive visual quality, and successfully transferring across seven state-of-the-art crowd models with transfer ratios ranging from 0.55 to 1.69. Our approach strikes a balance between attack effectiveness and imperceptibility compared to state-of-the-art transferable attack strategies. The source code is available at https://github.com/simurgh7/CrowdGen

Poster
cryoSENSE: Compressive Sensing Enables High-throughput Microscopy with Sparse and Generative Priors on the Protein Cryo-EM Image Manifold

Zain Shabeeb, Daniel Saeedi, Darin Tsui, Vida Jamali, Amirali Aghazadeh

展开摘要

Cryo-electron microscopy (cryo-EM) enables the atomic-resolution visualization of biomolecules; however, modern direct detectors generate data volumes that far exceed the available storage and transfer bandwidth, thereby constraining practical throughput. We introduce cryoSENSE, the computational realization of a hardware-software co-designed framework for compressive cryo-EM sensing and acquisition. We show that cryo-EM images of proteins lie on low-dimensional manifolds that can be independently represented using sparse priors in predefined bases and generative priors captured by a denoising diffusion model. cryoSENSE leverages these low-dimensional manifolds to enable faithful image reconstruction from spatial and Fourier-domain undersampled measurements while preserving downstream structural resolution. In experiments, cryoSENSE increases acquisition throughput by up to 2.5xwhile retaining the original 3D resolution, offering controllable trade-offs between the number of masked measurements and the level of downsampling. Sparse priors favor faithful reconstruction from Fourier-domain measurements and moderate compression, whereas generative diffusion priors achieve accurate recovery from pixel-domain measurements and more severe undersampling.

Poster
Making Training-Free Diffusion Segmentors Scale with the Generative Power

Benyuan Meng, Qianqian Xu, Zitai Wang, Xiaochun Cao, Longtao Huang, Qingming Huang

展开摘要

As powerful generative models, text-to-image diffusion models have recently been explored for discriminative tasks. A line of research focuses on adapting a pre-trained diffusion model to semantic segmentation without any further training, leading to training-free diffusion segmentors. These methods typically rely on cross-attention maps from the model's attention layers, which are assumed to capture semantic relationships between image pixels and text tokens. Ideally, such approaches should benefit from more powerful diffusion models, i.e., stronger generative capability should lead to better segmentation. However, we observe that existing methods often fail to scale accordingly. To understand this issue, we identify two underlying gaps: (i) Cross-attention is computed across multiple heads and layers, but there exists a discrepancy between these individual attention maps and a unified global representation. (ii) Even when a global map is available, it does not directly translate to accurate semantic correlation for segmentation, due to score imbalances among different text tokens. To bridge these gaps, we propose two techniques: auto aggregation and per-pixel rescaling, which together enable training-free segmentation to better leverage generative capability. We evaluate our approach on standard semantic segmentation benchmarks and further integrate it into a generative technique, demonstrating both improved performance and broad applicability. Codes are at https://github.com/Darkbblue/goca.

Poster
From Measurement to Mitigation: Quantifying and Reducing Identity Leakage in Image Representation Encoders with Linear Subspace Removal

Daniel George, Charles Yeh, Daniel Lee, Yifei Zhang

展开摘要

Frozen visual embeddings (e.g., CLIP, DINOv2/v3, SSCD) power retrieval and integrity systems, yet their use on face-containing data is constrained by unmeasured identity leakage and a lack of deployable mitigations. We take an attacker-aware view and contribute: (i) a benchmark of visual embeddings that reports open-set verification at low false-accept rates, a calibrated diffusion-based template inversion check, and face-context attribution with equal-area perturbations; and (ii) propose a one-shot linear projector that removes an estimated identity subspace while preserving the complementary space needed for utility, which for brevity we denote as the identity sanitization projection ISP. Across CelebA-20 and VGGFace2, we show that these encoders are robust under open-set linear probes, with CLIP exhibiting relatively higher leakage than DINOv2/v3 and SSCD, robust to template inversion, and are context-dominant. In addition, we show that ISP drives linear access to near-chance while retaining high non-biometric utility, and transfers across datasets with minor degradation. Our results establish the first attacker-calibrated facial privacy audit of non-FR encoders and demonstrate that linear subspace removal achieves strong privacy guarantees while preserving utility for visual search and retrieval.

Poster
SpaceTimePilot: Generative Rendering of Dynamic Scenes Across Space and Time

Zhening Huang, Hyeonho Jeong, Xuelin Chen, Yulia Gryaditskaya, Tuanfeng Y. Wang, Joan Lasenby, Chun-Hao Huang

展开摘要

We present SpaceTimePilot, a video diffusion model that disentangles space and time for controllable generative rendering. Given a monocular video, SpaceTimePilot can independently alter both the camera viewpoint and the motion sequence within the generative process, re-rendering the scene for continuous and arbitrary exploration across space and time. To achieve this, we introduce an effective animation time-embedding mechanism in the diffusion process, allowing explicit control of the output video's motion sequence with respect to that of the source video. As no datasets provide paired videos of the same dynamic scene with continuous temporal variations, we propose a temporal-warping training scheme that repurposes existing multi-view datasets to mimic temporal differences. This simple yet crucial strategy enables the model to learn temporal control, directly producing the observed space-time disentanglement effects.To further enhance the precision of dual control, we introduce two additional components: an improved camera-conditioning mechanism that allows altering the camera from the first frame, and CamxTime, the first synthetic Space and Time full-coverage rendering dataset that provides fully free space-time video trajectories within a scene. Joint training on the temporal-warping scheme and the CamxTime dataset yields more precise temporal control. We evaluate SpaceTimePilot on both real-world and synthetic data, demonstrating clear space-time disentanglement and strong results compared to prior arts.

Poster
SegCompass: Exploring Interpretable Alignment with Sparse Autoencoders for Enhanced Reasoning Segmentation

Zhenyu Lu, Liupeng Li, Jinpeng Wang, Haoqian Kang, Yan Feng, Ke Chen, Yaowei Wang

展开摘要

While large language models provide strong compositional reasoning, existing reasoning segmentation pipelines fail to transparently connect this reasoning to visual perception. Current methods, such as latent query alignment, are end-to-end yet opaque "black boxes". Conversely, textual localization readout is merely readable, not truly interpretable, often functioning as an unconstrained post-hoc step. To bridge this interpretability gap, we propose SegCompass, an end-to-end model that leverages a Sparse Autoencoder (SAE) to forge an explicit, interpretable, and differentiable alignment pathway. Given an image-instruction pair, SegCompass first generates a chain-of-thought (CoT) trace. The core of our method is an SAE that maps both the CoT and visual tokens into a shared, high-dimensional sparse concept space. A query codebook selects salient concepts from this space, which are then spatially grounded by a slot mapper into a multi-slot heatmap that guides the final mask decoder. The entire model is trained jointly, unifying reinforcement learning for the reasoning path with standard segmentation supervision. This SAE-driven interface provides a "white-box" connection that is significantly more traceable than latent queries and more coherent than textual readouts. Extensive experiments on five challenging benchmarks demonstrate that SegCompass matches or surpasses state-of-the-art performance. Crucially, our visual and quantitative analyses show a strong correlation between the quality of the learned sparse concepts and final mask accuracy, confirming that SegCompass achieves superior results through its enhanced and inspectable alignment. Code is available at https://github.com/ZhenyuLU-Heliodore/SegCompass.

Poster
MV2UV: Generating High-quality UV Texture Maps with Multiview Prompts

Zheng Zhang, Qinchuan Zhang, Yuteng Ye, Zhi Chen, Penglei Ji, Mengfei Li, Wenxiao Zhang, Yuan Liu

展开摘要

Generating high-quality textures for 3D assets is a challenging task. Existing multiview texture generation methods suffer from the multiview inconsistency and missing textures on unseen parts, while UV inpainting texture methods do not generalize well due to insufficient UV data and cannot well utilize 2D image diffusion priors. In this paper, we propose a new method called MV2UV that combines 2D generative priors from multiview generation and the inpainting ability of UV refinement to get high-quality texture maps. Our key idea is to adopt a UV space generative model that simultaneously inpaints unseen parts of multiview images while resolving the inconsistency of multiview images. Experiments show that our method enables a better texture generation quality than existing methods, especially in unseen occluded and multiview-inconsistent parts.

Poster
Sculpt4D: Generating 4D Shapes via Sparse-Attention Diffusion Transformers

Minghao Yin, Wenbo Hu, Jiale Xu, Ying Shan, Kai Han

展开摘要

Recent breakthroughs in 3D generative modeling have yielded remarkable progress in static shape synthesis, yet truly dynamic 4D generation remains elusive, hindered by temporal artifacts and prohibitive computational demand. We present Sculpt4D, a native 4D generative framework that seamlessly integrates efficient temporal modeling into a pretrained 3D Diffusion Transformer (Hunyuan3D 2.1), thereby mitigating the scarcity of 4D training data. At its core lies a Block Sparse Attention mechanism that preserves object identity by anchoring to the initial frame while capturing rich motion dynamics via a time-decaying sparse mask. This design faithfully models complex spatiotemporal dependencies with high fidelity, while sidestepping the quadratic overhead of full attention and reducing network total computation by 56%. Consequently, Sculpt4D establishes a new state-of-the-art in temporally coherent 4D synthesis, charting a path toward efficient and scalable 4D generation.

Poster
Synthetic Object Compositions for Scalable and Accurate Learning in Detection, Segmentation, and Grounding

Weikai Huang, Jieyu Zhang, Taoyang Jia, Chenhao Zheng, Ziqi Gao, Jae Sung Park, Ranjay Krishna

展开摘要

Visual grouping--operationalized through tasks such as instance segmentation, visual grounding, and object detection--enables applications ranging from robotic perception to photo editing. These fundamental problems in computer vision are powered by large-scale, painstakingly annotated datasets. Despite their impact, these datasets are costly to build, biased in coverage, and difficult to scale. Synthetic datasets offer a promising alternative but struggle with flexibility, accuracy, and compositional diversity. We introduce SOC, an accurate and scalable data synthesis pipeline via a novel object-centric composition strategy. It composes high-quality synthetic object segments into new images using 3D geometric layout augmentation and camera configuration augmentation with generative harmonization and mask-area-weighted blending, yielding accurate and diverse masks, boxes, and referring expressions. Models trained on just 100K of our synthetic images outperform those trained on larger real datasets (GRIT 20M, V3Det 200K) and synthetic pipelines (Copy-Paste, X-Paste, SynGround, SegGen by +24-36%)--achieving +10.9 AP on LVIS and +8.4 NAcc on gRefCOCO. SOC also enables controllable dataset construction for different use cases and boosts performance in both low-data and closed-vocabulary scenarios. Augmenting LVIS and COCO with synthetic object segments delivers strong performance across different real data scales and yields even greater improvements when real data is extremely limited (+6.59 AP on 1% COCO data). Furthermore, this controllability enables targeted data generation for intra-class referring, a diagnostic grounding task we propose that requires fine-grained attribute discrimination.

Poster
SV-GS: Sparse View 4D Reconstruction with Skeleton-Driven Gaussian Splatting

Jun–Jee Chao, Volkan Isler

展开摘要

Reconstructing a dynamic target moving over a large area is challenging. Standard approaches for dynamic object reconstruction require dense coverage in both the viewing space and the temporal dimension, typically relying on multi-view videos captured at each time step.However, such setups are only possible in constrained environments. In real-world scenarios, observations are often sparse over time and captured sparsely from diverse viewpoints (e.g., from security cameras), making dynamic reconstruction highly ill-posed. We present SV-GS, a framework that simultaneously estimates a deformation model and the object's motion over time under sparse observations. To initialize SV-GS, we leverage a rough skeleton graph and an initial static reconstruction as inputs to guide motion estimation. (Later, we show that this input requirement can be relaxed.) Our method optimizes a skeleton-driven deformation field composed of a coarse skeleton joint pose estimator and a module for fine-grained deformations. By making only the joint pose estimator time-dependent, our model enables smooth motion interpolation while preserving learned geometric details. Experiments on synthetic datasets show that our method outperforms existing approaches under sparse observations by up to 34% in PSNR, and achieves comparable performance to dense monocular video methods on real-world datasets despite using significantly fewer frames. Moreover, we demonstrate that the input initial static reconstruction can be replaced by a diffusion-based generative prior, making our method more practical for real-world scenarios.

Poster
TRIDENT: A Trimodal Cascade Generative Framework for Drug and RNA-Conditioned Cellular Morphology Synthesis

Rui Peng, Ziru Liu, Lingyuan Ye, Yuxing Lu, Boxin Shi, Jinzhuo Wang

展开摘要

Accurately modeling the relationship between perturbations, transcriptional responses, and phenotypic changes is essential for building an AI Virtual Cell (AIVC). However, existing methods typically constrained to modeling direct associations, such as *Perturbation -> RNA* or *Perturbation -> Morphology*, overlook the crucial causal link from RNA to morphology. To bridge this gap, we propose TRIDENT, a cascade generative framework that synthesizes realistic cellular morphology by conditioning on both the perturbation and the corresponding gene expression profile. To train and evaluate this task, we construct MorphoGene, a new dataset pairing L1000 gene expression with Cell Painting images for 98 compounds. TRIDENT significantly outperforms state-of-the-art approaches, achieving up to 7-fold improvement with strong generalization to unseen compounds. In a case study on docetaxel, we validate that RNA-guided synthesis accurately produces the corresponding phenotype. An ablation study further confirms that this RNA conditioning is essential for the model's high fidelity. By explicitly modeling transcriptome-phenome mapping, TRIDENT provides a powerful in silico tool and moves us closer to a predictive virtual cell.

Poster