CVPR 2026 论文列表

Conference on Computer Vision and Pattern Recognition

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4,042篇论文

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VisualAD: Language-Free Zero-Shot Anomaly Detection via Vision Transformer

Yanning Hou, Peiyuan Li, Zirui Liu, Yitong Wang, Yanran Ruan, Jianfeng Qiu, Ke Xu

展开摘要

Zero-shot anomaly detection (ZSAD) requires detecting and localizing anomalies without access to target-class anomaly samples. Mainstream methods rely on vision-language models (VLMs) such as CLIP: they build hand-crafted or learned prompt sets for normal and abnormal semantics, then compute image-text similarities for open-set discrimination. While effective, this paradigm depends on a text encoder and cross-modal alignment, which can lead to training instability and parameter redundancy. This work revisits the necessity of the text branch in ZSAD and presents VisualAD, a purely visual framework built on Vision Transformers. We introduce two learnable tokens within a frozen backbone to directly encode normality and abnormality. Through multi-layer self-attention, these tokens interact with patch tokens, gradually acquiring high-level notions of normality and anomaly while guiding patches to highlight anomaly-related cues. Additionally, we incorporate a Spatial-Aware Cross-Attention (SCA) module and a lightweight Self-Alignment Function (SAF): SCA injects fine-grained spatial information into the tokens, and SAF recalibrates patch features before anomaly scoring. VisualAD achieves state-of-the-art performance on 13 zero-shot anomaly detection benchmarks spanning industrial and medical domains, and adapts seamlessly to pretrained vision backbones such as the CLIP image encoder and DINOv2. Our code is publicly available at https://github.com/7HHHHH/VisualAD.

Poster
OralGPT-Omni: A Versatile Dental Multimodal Large Language Model

Jing Hao, Yuci Liang, Lizhuo Lin, Yuxuan Fan, Wenkai Zhou, Kaixin Guo, Zanting Ye, Yanpeng Sun, Xinyu Zhang, Yanqi Yang, Qiankun Li, Hao Tang, James Kit-Hon Tsoi, Linlin Shen, Kuo Feng Hung

展开摘要

Multimodal Large Language Models (MLLMs) have exhibited immense potential across numerous medical specialties, yet dentistry remains underexplored, in part due to limited domain-specific data, scarce dental expert annotations, insufficient modality-specific modeling, and challenges in reliability. In this paper, we present OralGPT-Omni, the first dental-specialized MLLM designed for comprehensive and trustworthy analysis across diverse dental imaging modalities and clinical tasks. To explicitly capture dentists' diagnostic reasoning, we construct TRACE-CoT, a clinically grounded chain-of-thought dataset that mirrors dental radiologists' decision-making processes. This reasoning supervision, combined with our proposed four-stage training paradigm, substantially strengthens the model's capacity for dental image understanding and analysis. In parallel, we introduce MMOral-Uni, the first unified multimodal benchmark for dental image analysis. It comprises 2,809 open-ended question-answer pairs spanning five modalities and five tasks, offering a comprehensive evaluation suite to date for MLLMs in digital dentistry. OralGPT-Omni achieves an overall score of 51.84 on the MMOral-Uni benchmark and 45.31 on the MMOral-OPG benchmark, dramatically outperforming the scores of GPT-5. Our work promotes intelligent dentistry and paves the way for future advances in dental image analysis. All code, benchmark, and models will be made publicly available.

Poster
MeshRipple: Structured Autoregressive Generation of Artist-Meshes

Junkai Lin, Hang Long, Huipeng Guo, Jielei Zhang, Jiayi Yang, Tianle Guo, Yang Yang, Jianwen Li, Wenxiao Zhang, Matthias Nießner, Wei Yang

展开摘要

Meshes serve as a primary representation for 3D assets. Autoregressive mesh generators serialize faces into sequences and train on truncated segments with sliding-window inference to cope with memory limits. However, this mismatch breaks long-range geometric dependencies, producing holes and fragmented components. To address this critical limitation, we introduce MeshRipple, which expands a mesh outward from an active generation frontier, akin to a ripple on a surface. MeshRipple rests on three key innovations: a frontier-aware BFS tokenization that aligns the generation order with surface topology; an expansive prediction strategy that maintains coherent, connected surface growth; and a sparse-attention global memory that provides an effectively unbounded receptive field to resolve long-range topological dependencies. This integrated design enables MeshRipple to generate meshes with high surface fidelity and topological completeness, outperforming strong recent baselines.

Poster
Love Me, Love My Label: Rethinking the Role of Labels in Prompt Retrieval for Visual In-Context Learning

Tianci Luo, Haohao Pan, Jinpeng Wang, Niu Lian, Xinrui Chen, Bin CHEN, Shu-Tao Xia, Chun Yuan

展开摘要

Visual in-context learning (VICL) enables visual foundation models to handle multiple tasks by steering them with demonstrative prompts. The choice of such prompts largely influences VICL performance, standing out as a key challenge. Prior work has made substantial progress on prompt retrieval and reranking strategies, but mainly focuses on prompt images while overlooking labels. We reveal these approaches sometimes get visually similar but label-inconsistent prompts, which potentially degrade VICL performance. On the other hand, higher label consistency between query and prompts preferably indicates stronger VICL results. Motivated by these findings, we develop a framework named LaPR (Label-aware Prompt Retrieval), which highlights the role of labels in prompt selection. Our framework first designs an image-label joint representation for prompts to incorporate label cues explicitly. Besides, to handle unavailable query labels at test time, we introduce a mixture-of-expert mechanism to the dual encoders with query-adaptive routing. Each expert is expected to capture a specific label mode, while the router infers query-adaptive mixture weights and helps to learn label-aware representation. We carefully design alternative optimization for experts and router, with a VICL performance-guided contrastive loss and a label-guided contrastive loss, respectively. Extensive experiments show promising and consistent improvement of LaPR on in-context segmentation, detection, and colorization tasks. Moreover, LaPR generalizes well across feature extractors and cross-fold scenarios, suggesting the importance of label utilization in prompt retrieval for VICL. Code is available at https://github.com/luotc-why/CVPR26-LaPR.

Poster
PQDT: Pseudo-Query Dual Transformer for Robust Point Cloud Restoration

Haoqing Wu, Alexa Nawotki, Jochen Garcke

展开摘要

Point clouds are a fundamental 3D representation in computer vision, enabling a wide range of perception tasks. However, real-world point clouds often suffer from degradations such as incompleteness, noise, outliers, and irregular density, caused by sensor limitations or occlusions. Recovering clean and detailed shapes from such degraded data is crucial for downstream applications. While existing learning-based methods achieve progress on individual tasks like completion or denoising, they typically rely on global bottleneck features, which lose fine-grained geometry and remain sensitive to varying input quality. We propose a unified 3D restoration network that directly takes point clouds as input and adaptively reconstructs high-quality geometry under diverse degradation scenarios. At the core of our approach is a Pseudo-Query module, implemented within a Transformer backbone, which reformulates geometric translation into two cooperative stages to enhance structural clarity, robustness, and local detail preservation. Extensive experiments on curated benchmarks demonstrate that our approach surpasses state-of-the-art performance in general 3D restoration. It effectively handles complex combinations of completion, deformation, and denoising degradations. With this work, we provide a novel unified, point-only backbone for robust 3D restoration, enabling more versatile 3D perception.

Poster
From Panel to Pixel: Zoom-In Vision-Language Pretraining from Biomedical Scientific Literature

Kun Yuan, Min Sun, Zhen Chen, Alejandro Lozano, Xiangteng He, Shi Li, Nassir Navab, Xiaoxiao Sun, Nicolas Padoy, Serena Yeung-Levy

展开摘要

There is growing interest in biomedical vision--language models trained on scientific literature. However, most pipelines compress rich multi-panel figures and long captions into coarse figure-level pairs, discarding the fine-grained correspondences clinicians rely on when zooming into local structures. We introduce Panel2Patch, a data pipeline that mines hierarchical structure from multi-panel, marker-heavy biomedical figures and their surrounding text, and converts them into multi-granular supervision. Given figures and captions, Panel2Patch parses layouts, panels, and visual markers, then constructs aligned image--text pairs at the figure, panel, and region levels, preserving local semantics instead of treating each figure as a single sample. Built on this corpus, we develop a granularity-aware pretraining strategy that unifies heterogeneous objectives from coarse didactic descriptions to fine region-focused phrases in a shared embedding space. Applying Panel2Patch to a small subset of literature figures yields substantially better performance than prior pipelines, demonstrating that exploiting hierarchical figure structure can provide more effective supervision with less pretraining data.

Poster
Edge-Focused Super-Resolution for Omnidirectional Images with Spherical Geometric Augmentation

Shaolin Wang, Yuying Li, Lei Zhong, Shigang Li, Jianfeng Li

展开摘要

Omnidirectional image super-resolution (ODISR) remains challenging due to extreme magnification factors (e.g., 8x, 16x) and projection-specific distortions, which degrade edge integrity and limit model performance. This paper proposes an edge-focused framework combined with spherical geometric augmentation to address these issues. Our approach includes an Edge Focused Block (EFB) that integrates spatial-channel attention via Edge Enhanced and Refined Blocks, strengthening edge feature capture and optimization. We also design an Edge-Aware Multi-Scale (EAM) pipeline, leveraging shallow convolutions for initial feature extraction, local modules for deep mining, and a Global Integration Block for multi-scale aggregation, ensuring coherent edge reconstruction in distorted regions. To mitigate data scarcity, we introduce a rotation-translation augmentation strategy based on spherical projections, expanding datasets while preserving scene continuity. Extensive experiments show our method outperforms state-of-the-art approaches on public datasets.

Poster
FloodDiffusion: Tailored Diffusion Forcing for Streaming Motion Generation

Yiyi Cai, Yuhan Wu, Kunhang Li, You Zhou, Bo Zheng, Haiyang Liu

展开摘要

We present FloodDiffusion, a new framework for text-driven, streaming human motion generation. Given time-varying text prompts, FloodDiffusion generates text-aligned, seamless motion sequences with real-time latency.Unlike existing methods that rely on chunk-by-chunk or auto-regressive model with diffusion head, we adopt a diffusion forcing framework to model this time-series generation task under time-varying control events.We find that a straightforward implementation of vanilla diffusion forcing (as proposed for video models) fails to model real motion distributions. We demonstrate that to guarantee modeling the output distribution, the vanilla diffusion forcing must be tailored to: (i) train with a bi-directional attention instead of casual attention; (ii) implement a lower triangular time scheduler instead of a random one; (iii) utilize a continues time-varying way to introduce text conditioning.With these improvements, we demonstrate in the first time that the diffusion forcing-based framework achieves state-of-the-art performance on the streaming motion generation task, reaching an FID of 0.057 on the HumanML3D benchmark. Models, code, and weights are available.

Poster
MSJoE: Jointly Evolving MLLM and Sampler for Efficient Long-Form Video Understanding

Wenhui Tan, Xiaoyi Yu, Jiaze Li, Yijing Chen, Jianzhong Ju, Zhenbo Luo, Ruihua Song, Jian Luan

展开摘要

Efficiently understanding long-form videos remains a fundamental challenge for Multimodal Large Language Models (MLLMs). In this paper, we present MLLM-Sampler Joint Evolution (MSJoE), a novel framework that jointly evolves the MLLM and a lightweight key-frame sampler for efficient long-form video understanding. MSJoE builds upon a key assumption that only a small subset of key-frames is truly informative for answering each question to a video. Specifically, MSJoE first reasons out several queries, which describe diverse visual perspectives relevant to the question. Then, these queries interact with a frozen CLIP model to produce a query-frame similarity matrix. Finally, A lightweight sampler predicts key-frame sampling weights from this matrix, selecting informative frames, which are then fed into the MLLM for answer generation. Both the MLLM and sampler are jointly optimized through reinforcement learning, enabling co-adaptation of query-reasoning, frame-sampling, and key-frame understanding. A new long-video QA dataset containing 2.8k videos with 7k question-answer pairs is collected to support the training process. Extensive experiments on VideoMME, LongVideoBench, LVBench, and MLVU show that MSJoE achieves 8.0% accuracy gain upon the base MLLM, and 1.1% higher accuracy than strongest baseline method.

Poster
VLM-Loc: Localization in Point Cloud Maps via Vision-Language Models

Shuhao Kang, Youqi Liao, Peijie Wang, Wenlong Liao, Qilin Zhang, Benjamin Busam, Xieyuanli Chen, Yun Liu

展开摘要

Text-to-point-cloud (T2P) localization aims to infer precise spatial positions within 3D point cloud maps from natural language descriptions, reflecting how humans perceive and communicate spatial layouts through language. However, existing methods largely rely on shallow text-point cloud correspondence without effective spatial reasoning, limiting their accuracy in complex environments. To address this limitation, we propose VLM-Loc, a framework that leverages the spatial reasoning capability of large vision-language models (VLMs) for T2P localization. Specifically, we transform point clouds into bird's-eye-view (BEV) images and scene graphs that jointly encode geometric and semantic context, providing structured inputs for the VLM to learn cross-modal representations bridging linguistic and spatial semantics. On top of these representations, we introduce a partial node assignment mechanism that explicitly associates textual cues with scene graph nodes, enabling interpretable spatial reasoning for accurate localization. To facilitate systematic evaluation across diverse scenes, we present CityLoc, a benchmark built from multi-source point clouds for fine-grained T2P localization. Experiments on CityLoc demonstrate VLM-Loc achieves superior accuracy and robustness compared to state-of-the-art methods. Our code, model, and dataset are available at \href https://github.com/MCG-NKU/nku-3d-vision repository .

Poster
OmniGen2: Towards Instruction-Aligned Multimodal Generation

Chenyuan Wu, Jiahao Wang, PengFei Zheng, Ruiran Yan, Shitao Xiao, Xin Luo, Yueze Wang, Wanli Li, Xiyan Jiang, Yexin Liu, Junjie Zhou, Ziyi Xia, Ze Liu, Chaofan Li, Haoge Deng, Kun Luo, Bo Zhang, Jiajun Zhang, Dong Liu, Defu Lian, Xinlong Wang, Zhongyuan Wang, Tiejun Huang, Zheng Liu

展开摘要

Multimodal generative models can process instructions in various modalities and demonstrate outstanding performance across a wide range of image generation tasks. However, their robustness in complex real-world scenarios remains limited due to insufficient generalized instruction alignment. We introduce OmniGen2, a unified multimodal generator designed to follow complex, fine-grained instructions. Our core contribution is a two-stage design that first builds a strong, world-knowledge-grounded foundation model and then aligns it using a progressive, multi-task instruction tuning strategy. The foundation model features a streamlined architecture with decoupled decoding for versatile multimodal generation and a novel positional encoding scheme to improve learning efficiency. We ground this model in real-world knowledge using large-scale data construction pipelines. Building on this foundation, we propose a progressive, reinforcement-based alignment process. This phase carefully schedules training tasks and reward signals to foster cross-task knowledge transfer, significantly improving the model's instruction-following capabilities. Our models demonstrate competitive performance on standard benchmarks and our dedicated in-context generation benchmark, OmniContext. We have released our models, code, benchmark, and training datasets at https://github.com/VectorSpaceLab/OmniGen2.

Poster
Coupling Liquid Time-Constant Encoders with Modern Hopfield Memory

Bishal Ranjan Swain, Kyung Joo Cheoi, Jaepil Ko

展开摘要

Continuous-time neural networks provide adaptive dynamics, but rely on a single hidden state to encode both fast input fluctuations and longer-term context. This shared representation forces rapidly changing inputs to overwrite slower contextual signals, causing the model to lose past information as new observations arrive. In contrast, biological perceptual systems maintain stable behaviour under evolving sensory input by integrating ongoing signals with stored associative patterns rather than relying on a single evolving state.Motivated by this distinction, we study a simple coupling of Liquid Time-Constant Networks (LTCs) with a Modern Hopfield Network (MHN) that serves as a content-addressable memory. At each time step, the liquid state is projected into a query, the MHN retrieves a memory vector, and the two representations are concatenated before a readout layer. We analyse this coupling under standard norm and Lipschitz assumptions and show that the combined representation remains bounded. We further show that the retrieval map contracts gradients for parameters upstream of the memory query, which provides a mechanism for reducing curvature in the loss landscape.On public time-series benchmarks, the coupled LTC-MHN model improves mean accuracy by 2.3% over competitive recurrent and continuous-time baselines and reduces the estimated Hessian trace by about an order of magnitude relative to a standalone LTC encoder, with the largest gains on classification tasks and competitive performance on a regression task. Qualitative analyses of training curves, loss landscapes, and latent embeddings support the interpretation that Hopfield retrieval smooths optimization and encourages more compact, linearly separable class manifolds. Code will be released upon publication.

Poster
GEM-TFL: Bridging Weak and Full Supervision for Forgery Localization through EM-Guided Decomposition and Temporal Refinement

Xiaodong Zhu, Yuanming Zheng, Suting Wang, Junqi Yang, Yuhong Yang, Weiping Tu, Zhongyuan Wang

展开摘要

Temporal Forgery Localization (TFL) aims to precisely identify manipulated segments within videos or audio streams, providing interpretable evidence for multimedia forensics and security. While most existing TFL methods rely on dense frame-level labels in a fully supervised manner, Weakly Supervised TFL (WS-TFL) reduces labeling cost by learning only from binary video-level labels. However, current WS-TFL approaches suffer from mismatched training and inference objectives, limited supervision from binary labels, gradient blockage caused by non-differentiable top-k aggregation, and the absence of explicit modeling of inter-proposal relationships. To address these issues, we propose GEM-TFL (Graph-based EM-powered Temporal Forgery Localization), a two-phase classification-regression framework that effectively bridges the supervision gap between training and inference. Built upon this foundation, (1) we enhance weak supervision by reformulating binary labels into multi-dimensional latent attributes through an EM-based optimization process; (2) we introduce a training-free temporal consistency refinement that realigns frame-level predictions for smoother temporal dynamics; and (3) we design a graph-based proposal refinement module that models temporal-semantic relationships among proposals for globally consistent confidence estimation. Extensive experiments on benchmark datasets demonstrate that GEM-TFL achieves more accurate and robust temporal forgery localization, substantially narrowing the gap with fully supervised methods.

Poster
AGFT: Alignment-Guided Fine-Tuning for Zero-Shot Adversarial Robustness of Vision-Language Models

Yubo Cui, Xianchao Guan, Zijun Xiong, Zheng Zhang

展开摘要

Pre-trained vision-language models (VLMs) exhibit strong zero-shot generalization but remain vulnerable to adversarial perturbations. Existing classification-guided adversarial fine-tuning methods often disrupt pre-trained cross-modal alignment, weakening visual-textual correspondence and degrading zero-shot performance. In this paper, we propose an Alignment-Guided Fine-Tuning (AGFT) framework that enhances zero-shot adversarial robustness while preserving the cross-modal semantic structure. Unlike label-based methods that rely on hard labels and fail to maintain the relative relationships between image and text, AGFT leverages the probabilistic predictions of the original model for text-guided adversarial training, which aligns adversarial visual features with textual embeddings via soft alignment distributions, improving zero-shot adversarial robustness. To address structural discrepancies introduced by fine-tuning, we introduce a distribution consistency calibration mechanism that adjusts the robust model's output to match a temperature-scaled version of the pre-trained model's predictions. Extensive experiments across multiple zero-shot benchmarks demonstrate that AGFT outperforms state-of-the-art methods while significantly improving zero-shot adversarial robustness. Code is available at https://github.com/YuboCui/AGFT.

Poster
Aesthetic Camera Viewpoint Suggestion with 3D Aesthetic Field

Sheyang Tang, Armin Shafiee Sarvestani, Jialu Xu, Xiaoyu Xu, Zhou Wang

展开摘要

The aesthetic quality of a scene depends strongly on camera viewpoint. Existing approaches for aesthetic viewpoint suggestion are either single-view adjustments, predicting limited camera adjustments from a single image without understanding scene geometry, or 3D exploration approaches, which rely on dense captures or prebuilt 3D environments coupled with costly reinforcement learning (RL) searches. In this work, we introduce the notion of 3D aesthetic field that enables geometry-grounded aesthetic reasoning in 3D with sparse captures, allowing efficient viewpoint suggestions in contrast to costly RL searches. We opt to learn this 3D aesthetic field using a feedforward 3D Gaussian Splatting network that distills high-level aesthetic knowledge from a pretrained 2D aesthetic model into 3D space, enabling aesthetic prediction for novel viewpoints from only sparse input views. Building on this field, we propose a two-stage search pipeline that combines coarse viewpoint sampling with gradient-based refinement, efficiently identifying aesthetically appealing viewpoints without dense captures or RL exploration. Extensive experiments show that our method consistently suggests viewpoints with superior framing and composition compared to existing approaches, establishing a new direction toward 3D-aware aesthetic modeling.

Poster
GroundingME: Exposing the Visual Grounding Gap in MLLMs through Multi-Dimensional Evaluation

Rang Li, Lei Li, Shuhuai Ren, Hao Tian, Shuhao Gu, Shicheng Li, Zihao Yue, Yudong Wang, Wenhan Ma, Zhe Yang, Jingyuan Ma, Zhifang Sui, Fuli Luo

展开摘要

Visual grounding, localizing objects from natural language descriptions, represents a critical bridge between language and vision understanding. While multimodal large language models (MLLMs) achieve impressive scores on existing benchmarks, a fundamental question remains: can MLLMs truly visually ground with human-like sophistication, or are they merely pattern-matching on simplified datasets? Current benchmarks fail to capture real-world complexity where humans effortlessly navigate intricate references and recognize when grounding is impossible. To rigorously assess MLLMs' true capabilities, we introduce GroundingME, a benchmark that systematically challenges models across four critical dimensions: (1) Discriminative: distinguishing highly similar objects, (2) Spatial: understanding complex relational descriptions, (3) Limited: handling occlusions or tiny objects, and (4) Rejection: recognizing ungroundable queries. Through careful curation combining automated generation with human verification, we create 1,005 challenging examples mirroring real-world complexity. Evaluating 25 state-of-the-art MLLMs reveals a profound capability gap: the best model achieves only 45.1% accuracy, while most score 0% on rejection tasks. We explore two strategies for improvements: (1) test-time scaling selects optimal response by thinking trajectory to improve overall performance by up to 4.5%, and (2) data-mixture training boosts rejection accuracy from 0% to 27.9%. GroundingME thus serves as both a diagnostic tool revealing current limitations in MLLMs and a roadmap toward human-level visual grounding. Project page: https://groundingme.github.io

Poster
UIKA: Fast Universal Head Avatar from Pose-Free Images

Zijian Wu, Boyao Zhou, Liangxiao Hu, Hongyu Liu, Yuan Sun, Xuan Wang, Xun Cao, Yujun Shen, Hao Zhu

展开摘要

We present UIKA, a feed-forward animatable Gaussian head model from an arbitrary number of pose-free inputs, including a single image, multi-view captures, and smartphone-captured videos. Unlike the traditional avatar method, which requires a studio-level multi-view capture system and reconstructs a human-specific model through a long-time optimization process, we rethink the task through the lenses of model representation, network design, and data preparation. First, we introduce a UV-guided avatar modeling strategy, in which each input image is associated with a pixel-wise facial correspondence estimation. Such correspondence estimation allows us to reproject each valid pixel color from screen space to UV space, which is independent of camera pose and character expression. Furthermore, we design learnable UV tokens on which the attention mechanism can be applied at both the screen and UV levels. The learned UV tokens can be decoded into canonical Gaussian attributes using aggregated UV information from all input views. To train our large avatar model, we additionally prepare a large-scale, identity-rich synthetic training dataset. Our method significantly outperforms existing approaches in both monocular and multi-view settings. See more details in our project page: https://zijian-wu.github.io/uika-page/.

Poster
Mitigating Simplicity Bias in OOD Detection through Object Co-occurrence Analysis

Boyang Dai, Chaoqi Chen, Yizhou Yu

展开摘要

Out-of-distribution (OOD) detection is crucial for ensuring the reliability of deep learning models. Existing methods mostly focus on regular entangled representations to discriminate in-distribution (ID) and OOD data, neglecting the rich contextual information within images. This issue is particularly challenging for detecting near-OOD, as models with simplicity bias struggle to learn discriminative features in disentangled representations. The human visual system can use the co-occurrence of objects in the natural environment to facilitate scene understanding. Inspired by this, we propose an Object-Centric OOD detection framework that learns to capture Object CO-occurrence (OCO) patterns within images. The proposed method introduces a new OOD detection paradigm that understands object co-occurrence within an image by predicting disentangled representations for the test sample, then adaptively divides patterns into three scenarios based on object co-occurrence patterns observed in ID training data, and finally performs OOD detection in a divide-and-conquer manner. By doing so, OCO can distinguish near-OOD by considering the semantic contextual relationships present in their images, avoiding the tendency to focus solely on simple, easily learnable regions. We evaluate OCO through experiments across challenging and full-spectrum OOD settings, demonstrating competitive results and confirming its ability to address both semantic and covariate shifts.

Poster
Bulk RNA-seq Guided Multi-modal Detection of Anomalous Regions in Human Cancer via Spatial Transcriptomics

Hang Shi, Ruocheng Yang, Wenjie You, Zhilin Huang, Daoqiang Zhang, Wei Shao

展开摘要

Spatial transcriptomics (ST) has emerged as a revolutionary approach in the field of tissue analysis that can offer spatial resolved molecular insights for the identification of anomalous regions (AR) on human cancers. Current ST-based methods for detecting AR focus narrowly on the molecular features of local tissue spots, overlooking the matched bulk RNA-seq data that contains crucial diagnostic information. This oversight limits their effectiveness in identifying subtle or heterogeneous tumors, where accurate detection depends on broader genetic context. Besides the genomic signatures, the pathological images can also provide rich visual information to reflect the morphology of AR. To utilize the patient-level diagnostic knowledge and harness complementary information from both histology images and ST, we develop a Bulk RNA-seq Guided Multi-modal Anomalous Regions Detection method (BRGMAR) for the identification of AR from human tissues. Specifically, to effectively model the dependencies in ST, we introduce a Dynamic Multi-Relational Graph Learning (DMRGL) module to adaptively capture complex relationships in ST, including both spatial proximity and gene expression similarity. Then, we design an Optimal Transportation-based Gene Module Alignment (OTGMA) approach to align ST data with patient-level bulk RNA-seq data by matching the compositional and functional similarities of their corresponding gene modules. Finally, we combine the learned genomic features with pathological image representations for accurate AR detection. We evaluate our method on three public available ST datasets for the purpose of identifying cancerous regions from normal tissues, and the experimental results demonstrate the advantage of our method in comparison with the existing studies.

Poster
GGPT: Geometry-Grounded Point Transformer

Yutong Chen, Yiming Wang, Xucong Zhang, Sergey Prokudin, Siyu Tang

展开摘要

Recent feed-forward networks have achieved remarkable progress in sparse-view 3D reconstruction by predicting dense point maps directly from RGB images. However, they often suffer from geometric inconsistencies and limited fine-grained accuracy due to the absence of explicit multi-view constraints. We introduce the Geometry-Grounded Point Transformer (GGPT), a framework that augments feed-forward reconstruction with reliable sparse geometric guidance. We first propose an improved Structure-from-Motion pipeline based on dense feature matching and lightweight geometric optimisation to efficiently estimate accurate camera poses and partial 3D point clouds from sparse input views. We propose a geometry-guided 3D point transformer that refines dense point maps under explicit partial-geometry supervision using an optimised guidance encoding. Extensive experiments demonstrate that our method provides a principled mechanism for integrating geometric priors with dense feed-forward predictions, producing reconstructions that are both geometrically consistent and spatially complete, recovering fine structures and filling gaps in textureless areas.Trained solely on ScanNet++ with VGGT predictions, GGPT generalises across architectures and datasets, substantially outperforming state-of-the-art feed-forward 3D reconstruction models in both in-domain and out-of-domain settings.

Poster