NeurIPS 2025 论文列表

Conference on Neural Information Processing Systems

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5,812篇论文

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主题: 图像生成 · 430 篇论文 · 重置筛选

Top-H Decoding: Adapting the Creativity and Coherence with Bounded Entropy in Text Generation

Erfan Baghaei Potraghloo, Seyedarmin Azizi, Souvik Kundu, Massoud Pedram

展开摘要

Large language models (LLMs), despite their impressive performance across a wide range of tasks, often struggle to balance two competing objectives in open-ended text generation: fostering diversity and creativity while preserving logical coherence. Existing truncated sampling techniques, including temperature scaling, top-*p* (nucleus) sampling, and min-*p* sampling, aim to manage this trade-off. However, they exhibit limitations, particularly in the effective incorporation of the confidence of the model into the corresponding sampling strategy. For example, min-*p* sampling relies on a single top token as a heuristic for confidence, eventually underutilizing the information of the probability distribution. To effectively incorporate the model confidence, this paper presents **_top-H_ decoding**. We first establish the theoretical foundation of the interplay between creativity and coherence in truncated sampling by formulating an **entropy-constrained minimum divergence** problem. We then prove this minimization problem to be equivalent to an **entropy-constrained mass maximization (ECMM)** problem, which is NP-hard. Finally, we present top-H decoding, a computationally efficient greedy algorithm to solve the ECMM problem. Extensive empirical evaluations demonstrate that top-H outperforms the state-of-the-art (SoTA) alternative of min-*p* sampling by up to **25.63%** on creative writing benchmarks, while maintaining robustness on question-answering datasets such as GPQA, GSM8K, and MT-Bench. Additionally, an *LLM-as-judge* evaluation confirms that top-H indeed produces coherent outputs even at higher temperatures, where creativity is especially critical. In summary, top-H advances SoTA in open-ended text generation and can be *easily integrated* into creative writing applications. The code is available at [https://github.com/ErfanBaghaei/Top-H-Decoding](https://github.com/ErfanBaghaei/Top-H-Decoding).

Poster
Deep Tree Tensor Networks

Chang Nie

展开摘要

Originating in quantum physics, tensor networks (TNs) have been widely adopted as exponential machines and parametric decomposers for recognition tasks. Typical TN models, such as Matrix Product States (MPS), have not yet achieved successful application in natural image recognition. When employed, they primarily serve to compress parameters within pre-existing networks, thereby losing their distinctive capability to enhance exponential-order feature interactions. This paper introduces a novel architecture named Deep Tree Tensor Network (DTTN), which captures -order multiplicative interactions across features through multilinear operations, while essentially unfolding into a tree-like TN topology with the parameter-sharing property. DTTN is stacked with multiple antisymmetric interacting modules (AIMs), and this design facilitates efficient implementation. Furthermore, our theoretical analysis demonstrates the equivalence between quantum-inspired TN models and polynomial/multilinear networks under specific conditions. We posit that the DTTN could catalyze more interpretable research within this field. The proposed model is evaluated across multiple benchmarks and application domains, demonstrating superior performance compared to both peer methods and state-of-the-art architectures. Our code will be made publicly available upon publication.

Poster
Semantic Surgery: Zero-Shot Concept Erasure in Diffusion Models

Lexiang Xiong, Liu Chengyu, Jingwen Ye, Yan Liu, Yuecong Xu

展开摘要

With the growing power of text-to-image diffusion models, their potential to generate harmful or biased content has become a pressing concern, motivating the development of concept erasure techniques. Existing approaches, whether relying on retraining or not, frequently compromise the generative capabilities of the target model in achieving concept erasure. Here, we introduce **Semantic Surgery**, a novel training-free framework for zero-shot concept erasure. Semantic Surgery directly operates on text embeddings *before* the diffusion process, aiming to neutralize undesired concepts at their semantic origin with dynamism to enhance both erasure completeness and the locality of generation. Specifically, Semantic Surgery dynamically estimates the presence of target concepts in an input prompt, based on which it performs a calibrated, scaled vector subtraction to neutralize their influence at the source. The overall framework consists of a Co-Occurrence Encoding module for robust multi-concept erasure and a visual feedback loop to address latent concept persistence, thereby reinforcing erasure throughout the subsequent denoising process. Our proposed Semantic Surgery requires no model retraining and adapts dynamically to the specific concepts and their intensity detected in each input prompt, ensuring precise and context-aware interventions. Extensive experiments are conducted on object, explicit content, artistic style, and multi-celebrity erasure tasks, demonstrating that our method significantly outperforms state-of-the-art approaches. That is, our proposed concept erasure framework achieves superior completeness and robustness while preserving locality and general image quality (e.g., achieving a 93.58 H-score in object erasure, reducing explicit content to just 1 instance with a 12.2 FID, and attaining an 8.09 H_a in style erasure with no MS-COCO FID/CLIP degradation). Crucially, this robustness enables our framework to function as a built-in threat detection system by monitoring concept presence scores, offering a highly effective and practical solution for safer text-to-image generation. Our code is publicly available at: https://github.com/Lexiang-Xiong/Semantic-Surgery

Poster
Deno-IF: Unsupervised Noisy Visible and Infrared Image Fusion Method

Han Xu, Yuyang Li, Yunfei Deng, Jiayi Ma, Guangcan Liu

展开摘要

Most image fusion methods are designed for ideal scenarios and struggle to handle noise. Existing noise-aware fusion methods are supervised and heavily rely on constructed paired data, limiting performance and generalization. This paper proposes a novel unsupervised noisy visible and infrared image fusion method, comprising two key modules. First, when only noisy source images are available, a convolutional low-rank optimization module decomposes clean components based on convolutional low-rank priors, guiding subsequent optimization. The unsupervised approach eliminates data dependency and enhances generalization across various and variable noise. Second, a unified network jointly realizes denoising and fusion. It consists of both intra-modal recovery and inter-modal recovery and fusion, also with a convolutional low-rankness loss for regularization. By exploiting the commonalities of denoising and fusion, the joint framework significantly reduces network complexity while expanding functionality. Extensive experiments validate the effectiveness and generalization of the proposed method for image fusion under various and variable noise conditions. The code is publicly available at https://github.com/hanna-xu/Deno-IF.

Spotlight
Enhancing Text-to-Image Diffusion Transformer via Split-Text Conditioning

Yu Zhang, Jialei Zhou, Xinchen Li, Qi Zhang, Zhongwei Wan, Duoqian Miao, Changwei Wang, Longbing Cao

展开摘要

Current text-to-image diffusion generation typically employs complete-text conditioning. Due to the intricate syntax, diffusion transformers (DiTs) inherently suffer from a comprehension defect of complete-text captions. One-fly complete-text input either overlooks critical semantic details or causes semantic confusion by simultaneously modeling diverse semantic primitive types. To mitigate this defect of DiTs, we propose a novel split-text conditioning framework named DiT-ST. This framework converts a complete-text caption into a split-text caption, a collection of simplified sentences, to explicitly express various semantic primitives and their interconnections. The split-text caption is then injected into different denoising stages of DiT-ST in a hierarchical and incremental manner. Specifically, DiT-ST leverages Large Language Models to parse captions, extracting diverse primitives and hierarchically sorting out and constructing these primitives into a split-text input. Moreover, we partition the diffusion denoising process according to its differential sensitivities to diverse semantic primitive types and determine the appropriate timesteps to incrementally inject tokens of diverse semantic primitive types into input tokens via cross-attention. In this way, DiT-ST enhances the representation learning of specific semantic primitive types across different stages. Extensive experiments validate the effectiveness of our proposed DiT-ST in mitigating the complete-text comprehension defect. Datasets and models are available.

Poster
SpecMER: Fast Protein Generation with K-mer Guided Speculative Decoding

Thomas Walton, Darin Tsui, Aryan Musharaf, Amirali Aghazadeh

展开摘要

Autoregressive models have transformed protein engineering by enabling the generation of novel protein sequences beyond those found in nature. However, their sequential inference introduces significant latency, limiting their utility in high-throughput protein screening. Speculative decoding accelerates generation by employing a lightweight draft model to sample tokens, which a larger target model then verifies and refines. Yet in protein sequence generation, draft models are typically agnostic to the structural and functional constraints of the target protein, leading to biologically implausible outputs and a shift in the likelihood distribution of generated sequences. We introduce SpecMER (Speculative Decoding via k-mer Guidance), a novel framework that incorporates biological, structural, and functional priors using k-mer motifs extracted from multiple sequence alignments. By scoring candidate sequences in parallel and selecting those most consistent with known biological patterns, SpecMER significantly improves sequence plausibility while retaining the efficiency of speculative decoding. SpecMER achieves 24–32% speedup over standard autoregressive decoding, along with higher acceptance rates and improved sequence likelihoods.

Spotlight
CamEdit: Continuous Camera Parameter Control for Photorealistic Image Editing

Xinran Qin, Zhixin Wang, Fan Li, Haoyu Chen, Renjing Pei, Wenbo Li, Xiaochun Cao

展开摘要

Recent advances in diffusion models have substantially improved text-driven image editing. However, existing frameworks based on discrete textual tokens struggle to support continuous control over camera parameters and smooth transitions in visual effects. These limitations hinder their applications to realistic, camera-aware, and fine-grained editing tasks. In this paper, we present CamEdit, a diffusion-based framework for photorealistic image editing that enables continuous and semantically meaningful manipulation of common camera parameters such as aperture and shutter speed. CamEdit incorporates a continuous parameter prompting mechanism and a parameter-aware modulation module that guides the model in smoothly adjusting focal plane, aperture, and shutter speed, reflecting the effects of varying camera settings within the diffusion process. To support supervised learning in this setting, we introduce CamEdit50K, a dataset specifically designed for photorealistic image editing with continuous camera parameter settings. It contains over 50k image pairs combining real and synthetic data with dense camera parameter variations across diverse scenes. Extensive experiments demonstrate that CamEdit enables flexible, consistent, and high-fidelity image editing, achieving state-of-the-art performance in camera-aware visual manipulation and fine-grained photographic control.

Poster
Denoising Trajectory Biases for Zero-Shot AI-Generated Image Detection

Yachao Liang, Min Yu, Gang Li, Jianguo Jiang, Fuqiang Du, Li Jingyuan, Lanchi Xie, Zhen Xu, Weiqing Huang

展开摘要

The rapid advancement of generative models has led to the widespread emergence of highly realistic synthetic images, making the detection of AI-generated content increasingly critical. In particular, diffusion models have recently achieved unprecedented levels of visual fidelity, further raising concerns. While most existing approaches rely on supervised learning, zero-shot detection methods have attracted growing interest due to their ability to bypass data collection and maintenance. Nevertheless, the performance of current zero-shot methods remains limited. In this paper, we introduce a novel zero-shot AI-generated image detection method. Unlike previous works that primarily focus on identifying artifacts in the final generated images, our work explores features within the image generation process that can be leveraged for detection. Specifically, we simulate the image sampling process via diffusion-based inversion and observe that the denoising outputs of generated images converge to the target image more rapidly than those of real images. Inspired by this observation, we compute the similarity between the original image and the outputs along the denoising trajectory, which is then used as an indicator of image authenticity.Since our method requires no training on any generated images, it avoids overfitting to specific generative models or dataset biases. Experiments across a wide range of generators demonstrate that our method achieves significant improvements over state-of-the-art supervised and zero-shot counterparts.

Poster
CovMatch: Cross-Covariance Guided Multimodal Dataset Distillation with Trainable Text Encoder

Yongmin Lee, Hye Won Chung

展开摘要

Multimodal dataset distillation aims to synthesize a small set of image-text pairs that enables efficient training of large-scale vision-language models. While dataset distillation has shown promise in unimodal tasks, extending it to multimodal contrastive learning presents key challenges: learning cross-modal alignment and managing the high computational cost of large encoders. Prior approaches address scalability by freezing the text encoder and update only the image encoder and text projection layer. However, we find this severely limits semantic alignment and becomes a bottleneck for performance scaling. We propose CovMatch, a scalable dataset distillation framework that aligns the cross-covariance of real and synthetic features while regularizing feature distributions within each modality. Unlike prior approaches, CovMatch enables joint optimization of both encoders, leading to stronger cross-modal alignment and improved performance. Evaluated on Flickr30K and COCO, CovMatch outperforms state-of-the-art multimodal distillation methods and achieves up to 6.8\% absolute gains in retrieval accuracy using only 500 synthetic pairs.

Poster
Conditional Panoramic Image Generation via Masked Autoregressive Modeling

Chaoyang Wang, Xiangtai Li, Lu Qi, Xiaofan Lin, Jinbin Bai, Qianyu Zhou, Yunhai Tong

展开摘要

Recent progress in panoramic image generation has underscored two critical limitations in existing approaches. First, most methods are built upon diffusion models, which are inherently ill-suited for equirectangular projection (ERP) panoramas due to the violation of the identically and independently distributed (i.i.d.) Gaussian noise assumption caused by their spherical mapping. Second, these methods often treat text-conditioned generation (text-to-panorama) and image-conditioned generation (panorama outpainting) as separate tasks, relying on distinct architectures and task-specific data. In this work, we propose a unified framework, Panoramic AutoRegressive model (PAR), which leverages masked autoregressive modeling to address these challenges. PAR avoids the i.i.d. assumption constraint and integrates text and image conditioning into a cohesive architecture, enabling seamless generation across tasks. To address the inherent discontinuity in existing generative models, we introduce circular padding to enhance spatial coherence and propose a consistency alignment strategy to improve the generation quality. Extensive experiments demonstrate competitive performance in text-to-image generation and panorama outpainting tasks while showcasing promising scalability and generalization capabilities.

Poster
Rendering-Aware Reinforcement Learning for Vector Graphics Generation

Juan A. Rodriguez, Haotian Zhang, Abhay Puri, Rishav Pramanik, Aarash Feizi, Pascal Wichmann, Arnab Kumar Mondal, Mohammad Reza Samsami, Rabiul Awal, Perouz Taslakian, Spandana Gella, Sai Rajeswar, David Vazquez, Christopher Pal, Marco Pedersoli

展开摘要

Scalable Vector Graphics (SVG) offer a powerful format for representing visual designs as interpretable code. Recent advances in vision-language models (VLMs) have enabled high-quality SVG generation by framing the problem as a code generation task and leveraging large-scale pretraining. VLMs are particularly suitable for this task as they capture both global semantics and fine-grained visual patterns, while transferring knowledge across vision, natural language, and code domains. However, existing VLM approaches often struggle to produce faithful and efficient SVGs because they never observe the rendered images during training. Although differentiable rendering for autoregressive SVG code generation remains unavailable, rendered outputs can still be compared to original inputs, enabling evaluative feedback suitable for reinforcement learning (RL). We introduce Reinforcement Learning from Rendering Feedback, an RL method that enhances SVG generation in autoregressive VLMs by leveraging feedback from rendered SVG outputs. Given an input image, the model generates SVG roll-outs that are rendered and compared to the original image to compute a reward. This visual fidelity feedback guides the model toward producing more accurate, efficient, and semantically coherent SVGs. \method significantly outperforms supervised fine-tuning, addressing common failure modes and enabling precise, high-quality SVG generation with strong structural understanding and generalization.

Poster
Detecting Generated Images by Fitting Natural Image Distributions

Yonggang Zhang, Jun Nie, Xinmei Tian, Mingming Gong, Kun Zhang, Bo Han

展开摘要

The increasing realism of generated images has raised significant concerns about their potential misuse, necessitating robust detection methods. Current approaches mainly rely on training binary classifiers, which depend heavily on the quantity and quality of available generated images. In this work, we propose a novel framework that exploits geometric differences between the data manifolds of natural and generated images. To exploit this difference, we employ a pair of functions engineered to yield consistent outputs for natural images but divergent outputs for generated ones, leveraging the property that their gradients reside in mutually orthogonal subspaces. This design enables a simple yet effective detection method: an image is identified as generated if a transformation along its data manifold induces a significant change in the loss value of a self-supervised model pre-trained on natural images. Further more, to address diminishing manifold disparities in advanced generative models, we leverage normalizing flows to amplify detectable differences by extruding generated images away from the natural image manifold. Extensive experiments demonstrate the efficacy of this method.

Spotlight
FlexVAR: Flexible Visual Autoregressive Modeling without Residual Prediction

Siyu Jiao, Gengwei Zhang, Yinlong Qian, Jiancheng Huang, Yao Zhao, Humphrey Shi, Lin Ma, Yunchao Wei, ZEQUN JIE

展开摘要

This work challenges the residual prediction paradigm in visual autoregressive modeling and presents FlexVAR, a new Flexible Visual AutoRegressive image generation paradigm. FlexVAR facilitates autoregressive learning with ground-truth prediction, enabling each step to independently produce plausible images. This simple, intuitive approach swiftly learns visual distributions and makes the generation process more flexible and adaptable. Trained solely on low-resolution images (< 256px), FlexVAR can: (1) Generate images of various resolutions and aspect ratios, even exceeding the resolution of the training images. (2) Support various image-to-image tasks, including image refinement, in/out-painting, and image expansion. (3) Adapt to various autoregressive steps, allowing for faster inference with fewer steps or enhancing image quality with more steps. Our 1.0B model outperforms its VAR counterpart on the ImageNet 256 × 256 benchmark. Moreover, when zero-shot transfer the image generation process with 13 steps, the performance further improves to 2.08 FID, outperforming state-of-the-art autoregressive models AiM/VAR by 0.25/0.28 FID and popular diffusion models LDM/DiT by 1.52/0.19 FID, respectively. When transferring our 1.0B model to the ImageNet 512 × 512 benchmark in a zero-shot manner, FlexVAR achieves competitive results compared to the VAR 2.3B model, which is a fully supervised model trained at 512 × 512 resolution.

Poster
ForgerySleuth: Empowering Multimodal Large Language Models for Image Manipulation Detection

Zhihao Sun, Haoran Jiang, Haoran Chen, Yixin Cao, Xipeng Qiu, Zuxuan Wu, Yu-Gang Jiang

展开摘要

Multimodal large language models have unlocked new possibilities for various multimodal tasks. However, their potential in image manipulation detection remains unexplored. When directly applied to the IMD task, M-LLMs often produce reasoning texts that suffer from hallucinations and overthinking. To address this, we propose ForgerySleuth, which leverages M-LLMs to perform comprehensive clue fusion and generate segmentation outputs indicating specific regions that are tampered with. Moreover, we construct the ForgeryAnalysis dataset through the Chain-of-Clues prompt, which includes analysis and reasoning text to upgrade the image manipulation detection task. A data engine is also introduced to build a larger-scale dataset for the pre-training phase. Our extensive experiments demonstrate the effectiveness of ForgeryAnalysis and show that ForgerySleuth significantly outperforms existing methods in generalization, robustness, and explainability.

Poster
GeoComplete: Geometry-Aware Diffusion for Reference-Driven Image Completion

Beibei Lin, Tingting Chen, Robby T. Tan

展开摘要

Reference-driven image completion, which restores missing regions in a target view using additional images, is particularly challenging when the target view differs significantly from the references. Existing generative methods rely solely on diffusion priors and, without geometric cues such as camera pose or depth, often produce misaligned or implausible content. We propose GeoComplete, a novel framework that incorporates explicit 3D structural guidance to enforce geometric consistency in the completed regions, setting it apart from prior image-only approaches. GeoComplete introduces two key ideas: conditioning the diffusion process on projected point clouds to infuse geometric information, and applying target-aware masking to guide the model toward relevant reference cues. The framework features a dual-branch diffusion architecture. One branch synthesizes the missing regions from the masked target, while the other extracts geometric features from the projected point cloud. Joint self-attention across branches ensures coherent and accurate completion. To address regions visible in references but absent in the target, we project the target view into each reference to detect occluded areas, which are then masked during training. This target-aware masking directs the model to focus on useful cues, enhancing performance in difficult scenarios. By integrating a geometry-aware dual-branch diffusion architecture with a target-aware masking strategy, GeoComplete offers a unified and robust solution for geometry-conditioned image completion. Experiments show that GeoComplete achieves a 17.1% PSNR improvement over state-of-the-art methods, significantly boosting geometric accuracy while maintaining high visual quality.

Poster
MGE-LDM: Joint Latent Diffusion for Simultaneous Music Generation and Source Extraction

Yunkee Chae, Kyogu Lee

展开摘要

We present MGE-LDM, a unified latent diffusion framework for simultaneous music generation, source imputation, and query-driven source separation. Unlike prior approaches constrained to fixed instrument classes, MGE-LDM learns a joint distribution over full mixtures, submixtures, and individual stems within a single compact latent diffusion model. At inference, MGE-LDM enables (1) complete mixture generation, (2) partial generation (i.e., source imputation), and (3) text-conditioned extraction of arbitrary sources. By formulating both separation and imputation as conditional inpainting tasks in the latent space, our approach supports flexible, class-agnostic manipulation of arbitrary instrument sources. Notably, MGE-LDM can be trained jointly across heterogeneous multi-track datasets (e.g., Slakh2100, MUSDB18, MoisesDB) without relying on predefined instrument categories.

Poster
DISCO: DISCrete nOise for Conditional Control in Text-to-Image Diffusion Models

Longquan Dai, Wu Ming, Dejiao Xue, He Wang, Jinhui Tang

展开摘要

A major challenge in using diffusion models is aligning outputs with user-defined conditions. Existing conditional generation methods fall into two major categories: classifier-based guidance, which requires differentiable target models and gradient-based correction; and classifier-free guidance, which embeds conditions directly into the diffusion model but demands expensive joint training and architectural coupling. In this work, we introduce a third paradigm: DISCrete nOise (DISCO) guidance, which replaces the continuous conditional correction term with a finite codebook of discrete noise vectors sampled from a Gaussian prior. Conditional generation is reformulated as a code selection task, and we train prediction network to choose the optimal code given the intermediate diffusion state and the conditioning input. Our approach is differentiability-free, and training-efficient, avoiding the gradient computation and architectural redundancy of prior methods. Empirical results demonstrate that DISCO achieves competitive controllability while substantially reducing resource demands, positioning it as a scalable and effective alternative for conditional diffusion generation.

Poster
BlurDM: A Blur Diffusion Model for Image Deblurring

Jin-Ting He, Fu-Jen Tsai, Yan-Tsung Peng, Min-Hung Chen, Chia-Wen Lin, Yen-Yu Lin

展开摘要

Diffusion models show promise for dynamic scene deblurring; however, existing studies often fail to leverage the intrinsic nature of the blurring process within diffusion models, limiting their full potential. To address it, we present a Blur Diffusion Model (BlurDM), which seamlessly integrates the blur formation process into diffusion for image deblurring. Observing that motion blur stems from continuous exposure, BlurDM implicitly models the blur formation process through a dual-diffusion forward scheme, diffusing both noise and blur onto a sharp image. During the reverse generation process, we derive a dual denoising and deblurring formulation, enabling BlurDM to recover the sharp image by simultaneously denoising and deblurring, given pure Gaussian noise conditioned on the blurred image as input. Additionally, to efficiently integrate BlurDM into deblurring networks, we perform BlurDM in the latent space, forming a flexible prior generation network for deblurring. Extensive experiments demonstrate that BlurDM significantly and consistently enhances existing deblurring methods on four benchmark datasets. The source code is available at https://github.com/Jin-Ting-He/BlurDM.

Poster
GeoCAD: Local Geometry-Controllable CAD Generation with Large Language Models

Zhanwei Zhang, kaiyuan liu, Junjie LIU, Wenxiao Wang, Binbin Lin, Liang Xie, Chen Shen, Deng Cai

展开摘要

Local geometry-controllable computer-aided design (CAD) generation aims to modify local parts of CAD models automatically, enhancing design efficiency. It also ensures that the shapes of newly generated local parts follow user-specific geometric instructions (e.g., an isosceles right triangle or a rectangle with one corner cut off). However, existing methods encounter challenges in achieving this goal. Specifically, they either lack the ability to follow textual instructions or are unable to focus on the local parts. To address this limitation, we introduce GeoCAD, a user-friendly and local geometry-controllable CAD generation method. Specifically, we first propose a complementary captioning strategy to generate geometric instructions for local parts. This strategy involves vertex-based and VLLM-based captioning for systematically annotating simple and complex parts, respectively. In this way, we caption $\sim$221k different local parts in total. In the training stage, given a CAD model, we randomly mask a local part. Then, using its geometric instruction and the remaining parts as input, we prompt large language models (LLMs) to predict the masked part. During inference, users can specify any local part for modification while adhering to a variety of predefined geometric instructions. Extensive experiments demonstrate the effectiveness of GeoCAD in generation quality, validity and text-to-CAD consistency.

Poster
TEMPO: Temporal Multi-scale Autoregressive Generation of Protein Conformational Ensembles

Yaoyao Xu, Di Wang, Zihan Zhou, Tianshu Yu, Mingchen Chen

展开摘要

Understanding the dynamic behavior of proteins is critical to elucidating their functional mechanisms, yet generating realistic, temporally coherent trajectories of protein ensembles remains a significant challenge. In this work, we introduce a novel hierarchical autoregressive framework for modeling protein dynamics that leverages the intrinsic multi-scale organization of molecular motions. Unlike existing methods that focus on generating static conformational ensembles or treat dynamic sampling as an independent process, our approach characterizes protein dynamics as a Markovian process. The framework employs a two-scale architecture: a low-resolution model captures slow, collective motions driving major conformational transitions, while a high-resolution model generates detailed local fluctuations conditioned on these large-scale movements. This hierarchical design ensures that the causal dependencies inherent in protein dynamics are preserved, enabling the generation of temporally coherent and physically realistic trajectories. By bridging high-level biophysical principles with state-of-the-art generative modeling, our approach provides an efficient framework for simulating protein dynamics that balances computational efficiency with physical accuracy.

Poster