ICLR 2026 论文列表

Virtual cell modeling aims to predict cellular responses to perturbations. Existing virtual cell models rely heavily on large-scale single-cell datasets, learning explicit mappings between gene expression and perturbations. Although recent models attempt to incorporate multi-source biological information, their generalization remains constrained by data quality, coverage, and batch effects. More critically, these models often function as black boxes, offering predictions without interpretability or consistency with biological principles, which undermines their credibility in scientific research. To address these challenges, we present VCWorld, a cell-level white-box simulator that integrates structured biological knowledge with the iterative reasoning capabilities of large language models to instantiate a biological world model. VCWorld operates in a data-efficient manner to reproduce perturbation-induced signaling cascades and generates interpretable, stepwise predictions alongside explicit mechanistic hypotheses. In drug perturbation benchmarks, VCWorld achieves state-of-the-art predictive performance, and the inferred mechanistic pathways are consistent with publicly available biological evidence. Our code is publicly available at https://anonymous.4open.science/r/VCWorld-B970.

Optimistic exploration is central to improving sample efficiency in reinforcement learning with human feedback, yet existing exploratory bonus methods often fail to realize true optimism. We provide a theoretical analysis showing that current formulations, under KL or $\alpha$-divergence regularization, unintentionally bias exploration toward high-probability regions of the reference model, thereby reinforcing conservative behavior instead of promoting discovery of uncertain regions. To address this pitfall, we introduce the General Exploratory Bonus (GEB), a novel theoretical framework that provably satisfies the optimism principle. GEB counteracts divergence-induced bias via reference-dependent reward regulation and unifies prior heuristic bonuses as special cases, while extending naturally across the full $\alpha$-divergence family. Empirically, GEB consistently outperforms baselines on alignment tasks across multiple divergence settings and large language model backbones. These results demonstrate that GEB offers both a principled and practical solution for optimistic exploration in RLHF.

Modern camera pipelines apply extensive on-device processing, such as exposure adjustment, white balance, and color correction, which, while beneficial individually, often introduce photometric inconsistencies across views. These appearance variations violate multi-view consistency and degrade novel view synthesis. Joint optimization of scene-specific representations and per-image appearance embeddings has been proposed to address this issue, but with increased computational complexity and slower training. In this work, we propose a generalizable, feed-forward approach that predicts spatially adaptive bilateral grids to correct photometric variations in a multi-view consistent manner. Our model processes hundreds of frames in a single step, enabling efficient large-scale harmonization, and seamlessly integrates into downstream 3D reconstruction models, providing cross-scene generalization without requiring scene-specific retraining. To overcome the lack of paired data, we employ a hybrid self-supervised rendering loss leveraging 3D foundation models, improving generalization to real-world variations. Extensive experiments show that our approach outperforms or matches the reconstruction quality of existing scene-specific optimization methods with appearance modeling, without significantly affecting the training time of baseline 3D models.

Current online reinforcement learning (RL) algorithms like GRPO share a key limitation in LLM reasoning: they cannot learn from problems that are "unsolvable" to the model. In other words, they can only improve performance on problems where the model is capable of exploring the correct answer. If a problem is too difficult -- such that even hundreds of attempts never produce a correct solution -- the model cannot learn from it. Consequently, the model's "upper limit" remains unchanged after RL training, even though the likelihood of solving easier, solvable problems may increase. These hard, unsolvable samples -- though potentially rich in learning signal -- cannot contribute to training, as no rollouts yield rewards and thus no gradients are produced. To unlock learning from these hard samples, we propose NuRL, a "nudging" method that aims to push the upper bound of LLM reasoning using self-generated hints, i.e., abstract cues that help reduce the problem difficulty for the model. Given a question and its gold answer, the model generates a Chain-of-Thought (CoT) and then produces a hint containing the core knowledge needed to solve the problem. During online RL training, we generate G rollouts from the base policy and use the pass rate to decide whether the hint should be injected. For hard samples with a 0% pass rate, we inject the offline-generated hint and regenerate a new batch of trajectories. This yields two benefits: (1) the hint boosts pass rates (from 0% to non-zero), thereby introducing training signals for previously unsolvable samples, and (2) the hints are self-generated (conditioned on the gold answer), avoiding distributional shift and do not rely on external models. Compared to standard GRPO, NuRL achieves consistent improvements across six diverse benchmarks and three models, while remaining complementary to test-time scaling. Notably, NuRL can raise the model's upper limit, whereas GRPO leaves pass@1024 unchanged from the base model. Furthermore, we present a systematic study of what makes an effective hint and when hints are most useful. Interestingly, the best hints are abstract and high-level -- as revealing gold answers actually hurt performance -- and are most beneficial when applied necessarily and after GRPO has converged.

Multimodal Large Language Models (MLLMs) have achieved remarkable success in image and short video understanding tasks, but their performance on hour-long videos remains limited due to constraint of input token capacity. Existing approaches often require costly training procedures, hindering their adaptability to rapidly evolving MLLM architectures. In this paper, we propose a training-free framework for long video understanding, integrating three key innovations: Adaptive Frame Sampling (AFS), Dynamic Resolution Allocation (DRA), and Video-Query-Options Similarity (VQOS). AFS adaptively increases frame sampling density in highly relevant video segments to preserve critical temporal details, while DRA reduces spatial resolution in less relevant segments to suppress redundant information. VQOS enhances similarity calculation by prompting MLLMs to generate candidate answer options, fusing queries with options to refine relevance estimation. Mirroring human cognitive processes (hypothesis generation → focused verification → irrelevance filtering), our framework effectively improve model accuracy without fine-tuning. The method is implemented on LLaVA-Video and Qwen2.5-VL respectively, and experimental results show our method could achieve state-of-the-art performances over 5 mainstream benchmarks. More visualization results and code are available in the Appendix.

Multimodal Large Language Models (MLLMs) face significant computational overhead when processing long videos due to the massive number of visual tokens required. To improve efficiency, existing methods primarily reduce redundancy by pruning or merging tokens based on importance or similarity. However, these approaches largely overlook a critical dimension of video content, i.e., changes and turning points, and they lack a collaborative model for spatio-temporal relationships. To address this, we propose a new perspective: similarity is for identifying redundancy, while difference is for capturing key events. Based on this, we designed a training-free framework named ST-SimDiff. We first construct a spatio-temporal graph from the visual tokens to uniformly model their complex associations. Subsequently, we employ a parallel dual-selection strategy: 1) similarity-based selection uses community detection to retain representative tokens, compressing static information; 2) temporal difference-based selection precisely locates content-changing points to preserve tokens that capture key dynamic shifts. This allows it to preserve both static and dynamic content with a minimal number of tokens. Extensive experiments show our method significantly outperforms state-of-the-art approaches while substantially reducing computational costs. Our code is available in [https://anonymous.4open.science/r/ST-SimDiff-7225](https://anonymous.4open.science/r/ST-SimDiff-7225).

Achieving generalizable bimanual manipulation requires systems that can learn efficiently from minimal human input while adapting to real-world uncertainties and diverse embodiments. Existing approaches face a dilemma: imitation policy learning demands extensive demonstrations to cover task variations, while modular methods often lack flexibility in dynamic scenes. We introduce VLBiMan, a framework that derives reusable skills from a single human example through task-aware decomposition, preserving invariant primitives as anchors while dynamically adapting adjustable components via vision-language grounding. This adaptation mechanism resolves scene ambiguities caused by background changes, object repositioning, or visual clutter without policy retraining, leveraging semantic parsing and geometric feasibility constraints. Moreover, the system inherits human-like hybrid control capabilities, enabling mixed synchronous and asynchronous use of both arms. Extensive experiments validate VLBiMan across tool-use and multi-object tasks, demonstrating: (1) a drastic reduction in demonstration requirements compared to imitation baselines, (2) compositional generalization through atomic skill splicing for long-horizon tasks, (3) robustness to novel but semantically similar objects and external disturbances, and (4) strong cross-embodiment transfer, showing that skills learned from human demonstrations can be instantiated on different robotic platforms without retraining. By bridging human priors with vision-language anchored adaptation, our work takes a step toward practical and versatile dual-arm manipulation in unstructured settings.

Enhancing the complex reasoning capabilities of Large Language Models (LLMs) attracts widespread attention. While reinforcement learning (RL) has shown superior performance for improving complex reasoning, its impact on cross-lingual generalization compared to Supervised Fine-Tuning (SFT) remains unexplored. We present the first systematic investigation into cross-lingual reasoning generalization of RL and SFT. Using Qwen2.5-3B-Base as our foundation model, we conduct experiments on diverse multilingual reasoning benchmarks, including math reasoning, commonsense reasoning, and scientific reasoning. Our investigation yields two significant findings: (1) Tuning with RL not only achieves higher accuracy but also demonstrates substantially stronger cross-lingual generalization capabilities compared to SFT. (2) RL training on non-English data yields better overall performance and generalization than training on English data, which is not observed with SFT. Furthermore, through comprehensive mechanistic analyses, we explore the underlying factors of RL's superiority and generalization across languages. Our results provide compelling evidence that RL enables the model with more robust reasoning strategies, offering crucial guidance for more equitable and effective multilingual reasoning.

We introduce GDPval, a benchmark evaluating AI model capabilities on real-world economically valuable knowledge-work tasks. GDPval covers the majority of Department of Labor O*NET Work Activities for 44 occupations across the top 9 sectors contributing to U.S. GDP (Gross Domestic Product). Tasks are constructed from the representative work of industry professionals with an average of 14 years of experience. We find that frontier model performance on GDPval is improving roughly linearly over time, and that the current best frontier models are approaching industry experts in deliverable quality. We analyze the potential for frontier models, when paired with human oversight, to perform GDPval tasks cheaper and faster than unaided experts. We also demonstrate that increased reasoning effort, increased task context, and increased scaffolding improves model performance on GDPval. Finally, we open-source a gold subset of 220 tasks and provide a public automated grading service to facilitate future research in understanding real-world model capabilities.

Attention-based regression models are often trained by jointly optimizing Mean Squared Error (MSE) loss and Pearson correlation coefficient (PCC) loss, emphasizing the magnitude of errors and the order or shape of targets, respectively. A common but poorly understood phenomenon during training is the *PCC plateau*: PCC stops improving early in training, even as MSE continues to decrease. We provide the first rigorous theoretical analysis of this behavior, revealing fundamental limitations in both optimization dynamics and model capacity. First, in regard to the flattened PCC curve, we uncover a critical conflict where lowering MSE (magnitude matching) can *paradoxically* suppress the PCC gradient (shape matching). This issue is exacerbated by the softmax attention mechanism, particularly when the data to be aggregated is highly homogeneous. Second, we identify a limitation in the model capacity: we derived a PCC improvement limit for *any* convex aggregator (including the softmax attention), showing that the convex hull of the inputs strictly bounds the achievable PCC gain. We demonstrate that data homogeneity intensifies both limitations. Motivated by these insights, we propose the Extrapolative Correlation Attention (ECA), which incorporates novel, theoretically-motivated mechanisms to improve the PCC optimization and extrapolate beyond the convex hull. Across diverse benchmarks, including challenging homogeneous data setting, ECA consistently breaks the PCC plateau, achieving significant improvements in correlation without compromising MSE performance.

Large Language Models (LLMs) have been extensively studied for their memory ability, yet the capacity to selectively forget during inference remains underexplored. We introduce ICF-Bench, a comprehensive benchmark for evaluating In-Context Forgetting (ICF). We define ICF as the ability of LLMs to selectively forget interference information while retaining useful knowledge in context without parameter updates. Built on high-quality datasets, ICF-Bench comprises 2k multi-turn dialogues with annotations that reflect realistic scenarios. Extensive experiments of advanced LLMs on ICF-Bench reveal that: (1) models perform well without forgetting interference but struggle significantly when interference is present; (2) stronger memory capacity without forgetting interference does not transfer into stronger ICF capacity, highlighting an asymmetry between memory and ICF; and (3) context length has different effects on ICF capacity across scenarios. These findings expose critical vulnerabilities of current LLMs in terms of privacy protection, adaptability, and user autonomy. Our code and data will be available at https://anonymous.4open.science/r/ICF-Bench-B1C7.

Masked diffusion large language models (dLLMs) are emerging as promising alternatives to autoregressive LLMs, offering competitive performance while supporting unique generation capabilities such as inpainting. We explore how inpainting can inform RL algorithm design for dLLMs. Aligning LLMs with reinforcement learning faces an exploration challenge: sparse reward signals and sample waste when models fail to discover correct solutions. While this inefficiency affects LLMs broadly, dLLMs offer a distinctive opportunity—their inpainting ability can guide exploration. We introduce IGPO (Inpainting Guided Policy Optimization), an RL framework that strategically inserts partial ground-truth reasoning traces during online sampling. Unlike providing full solutions, inpainting steers exploration toward promising trajectory spaces while preserving self-generated reasoning, bridging supervised fine-tuning and reinforcement learning. We apply IGPO to group-based optimization methods such as GRPO, where exploration failures cause zero advantages and gradients. IGPO restores meaningful gradients while improving sample efficiency. We also propose supervised fine-tuning on synthetically rewritten concise traces that better align with dLLM generation patterns. With additional techniques including entropy-based filtering, our training recipe yields substantial gains across four mathematical benchmarks—GSM8K, Math500, AMC and Minerva—achieving new state-of-the-art results for full-attention masked dLLMs.

Modeling 3D dynamics is a fundamental problem in multi-body systems across scientific and engineering domains and has important practical implications in trajectory prediction and simulation. While recent GNN-based approaches have achieved strong performance by enforcing geometric symmetries, encoding high-order features or incorporating neural-ODE mechanics, they typically depend on explicitly observed structures and inherently fail to capture the unobserved interactions that are crucial to complex physical behaviors and dynamics mechanism. In this paper, we propose PAINET, a principled SE(3)-equivariant neural architecture for learning all-pair interactions in multi-body systems. The model comprises: (1) a novel physics-inspired attention network derived from the minimization trajectory of an energy function, and (2) a parallel decoder that preserves equivariance while enabling efficient inference. Empirical results on diverse real-world benchmarks, including human motion capture, molecular dynamics, and large-scale protein simulations, show that PAINET consistently outperforms recently proposed models, yielding 4.7% to 41.5% error reductions in 3D dynamics prediction with comparable computation costs in terms of time and memory. Our codes, baseline models and datasets are available at https://anonymous.4open.science/r/PAINET-4668.

We tackle the task of long-form music generation, particularly the challenging \textbf{lyrics-to-song} problem, by introducing \textbf{YuE (乐)}, a family of open-source music generation foundation models. Specifically, YuE scales to trillions of tokens and generates up to five minutes of music while maintaining lyrical alignment, coherent musical structure, and engaging vocal melodies with appropriate accompaniment. It achieves this through \textbf{track-decoupled next-token prediction} to overcome dense mixture signals, and \textbf{structural progressive conditioning} for long-context lyrical alignment. In addition, we redesign the \textbf{in-context learning} technique for music generation, enabling bidirectional content creation, style cloning, and improving musicality. Through extensive evaluation, we demonstrate that YuE matches or even surpasses some of the proprietary systems in musicality and vocal agility (as of 2025-01). We strongly encourage readers to \textbf{listen to our demo}\footnote{\url{https://yue-anonymous.github.io}}.

In arbitrary-order language models, it is an open question how to sample tokens in parallel from the correct joint distribution. With discrete diffusion models, the more tokens they generate in parallel, the less their predicted distributions adhere to the originally learned data distribution, as they rely on a conditional independence assumption that only works with infinitesimally small timesteps. We find that a different class of models, any-subset autoregressive models (AS-ARMs), holds the solution. As implied by the name, AS-ARMs can generate tokens in any order, and in parallel. Moreover, AS-ARMs support parallelized joint probability density estimation, allowing them to correct their own parallel-generated token distributions, via our Any-Subset Speculative Decoding (ASSD) algorithm. ASSD provably enables generation of tokens from the correct joint distribution, with the number of neural network calls upper bounded by the number of tokens predicted – notably, previous speculative decoding algorithms lack our efficiency guarantee. We empirically verify that ASSD speeds up language generation, without sacrificing quality. Furthermore, we provide a mathematically justified scheme for training AS-ARMs for generation, and show that AS-ARMs achieve state-of-the-art performance among sub-200M parameter models on infilling benchmark tasks, and nearly match the performance of models 50X larger on code generation. Our theoretical and empirical results indicate that the once-forgotten AS-ARMs are a promising direction of language modeling.

Recent works have explored reference-based super-resolution (RefSR) to mitigate hallucinations in diffusion-based image restoration. A key challenge is that real-world degradations make correspondences between low-quality (LQ) inputs and reference (Ref) images unreliable, requiring adaptive control of reference usage. Existing methods either ignore LQ–Ref correlations or rely on brittle explicit matching, leading to over-reliance on misleading references or under-utilization of valuable cues. To address this, we propose Ada-RefSR, a single-step diffusion framework guided by a "Trust but Verify " principle: reference information is leveraged when reliable and suppressed otherwise. Its core component, Adaptive Implicit Correlation Gating (AICG), employs learnable summary tokens to distill dominant reference patterns and capture implicit correlations with LQ features. Integrated into the attention backbone, AICG provides lightweight, adaptive regulation of reference guidance, serving as a built-in safeguard against erroneous fusion. Experiments on multiple datasets demonstrate that Ada-RefSR achieves a strong balance of fidelity, naturalness, and efficiency, while remaining robust under varying reference alignment. Code and models are available at https://github.com/vivoCameraResearch/AdaRefSR.

We study density estimation from pairwise comparisons, motivated by expert knowledge elicitation and learning from human feedback. We relate the unobserved target density to a tempered winner density (marginal density of preferred choices), learning the winner's score via score-matching. This allows estimating the target by `de-tempering' the estimated winner density's score. We prove that the score vectors of the belief and the winner density are collinear, linked by a position-dependent tempering field. We give analytical formulas for this field and propose an estimator for it under the Bradley-Terry model. Using a diffusion model trained on tempered samples generated via score-scaled annealed Langevin dynamics, we can learn complex multivariate belief densities of simulated experts, from only hundreds to thousands of pairwise comparisons.

Recent studies have extended Reinforcement Learning with Verifiable Rewards (RLVR) to autoregressive (AR) visual generation and achieved promising progress. However, existing methods typically apply uniform optimization across all image tokens, while the varying contributions of different image tokens for RLVR's training remain unexplored. In fact, the key obstacle lies in how to identify more critical image tokens during AR generation and implement effective token-wise optimization for them. To tackle this challenge, we propose $\textbf{G}$roup $\textbf{C}$ritical-token $\textbf{P}$olicy $\textbf{O}$ptimization ($\textbf{GCPO}$), which facilitates effective policy optimization on critical tokens. We identify the critical tokens in RLVR-based AR generation from three perspectives, specifically: $\textbf{(1)}$ Causal dependency: early tokens fundamentally determine the later tokens and final image effect due to unidirectional dependency; $\textbf{(2)}$ Entropy-induced spatial structure: tokens with high entropy gradients correspond to image structure and bridges distinct visual regions; $\textbf{(3)}$ RLVR-focused token diversity: tokens with low visual similarity across a group of sampled images contribute to richer token-level diversity. For these identified critical tokens, we further introduce a dynamic token-wise advantage weight to encourage exploration, based on confidence divergence between the policy model and reference model. By leveraging 30\% of the image tokens, GCPO achieves better performance than GRPO with full tokens. Extensive experiments on multiple text-to-image benchmarks for both AR models and unified multimodal models demonstrate the effectiveness of GCPO for AR visual generation.

Personalized alignment of large language models seeks to adapt responses to individual user preferences, typically via reinforcement learning. A key challenge is obtaining accurate, user-specific reward signals in open-ended scenarios. Existing personalized reward models face two persistent limitations: (1) oversimplifying diverse, scenario-specific preferences into a small, fixed set of evaluation principles, and (2) struggling with generalization to new users with limited feedback. To this end, we propose **P-GenRM**, the first **P**ersonalized **Gen**erative **R**eward **M**odel with test-time user-based scaling. P-GenRM transforms preference signals into structured evaluation chains that derive adaptive personas and scoring rubrics across various scenarios. It further clusters users into User Prototypes and introduces a dual-granularity scaling mechanism: at the individual level, it adaptively scales and aggregates each user’s scoring scheme; at the prototype level, it incorporates preferences from similar users. This design mitigates noise in inferred preferences and enhances generalization to unseen users through prototype-based transfer. Empirical results show that P-GenRM achieves state-of-the-art results on widely-used personalized reward model benchmarks, with an average improvement of ~2.31\%, and demonstrates strong generalization on an out-of-distribution dataset. Notably, Test-time User-based scaling provides an additional ~3\% boost, demonstrating stronger personalized alignment with test-time scalability.