ICLR 2026 论文列表

International Conference on Learning Representations

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5,358篇论文

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  • Oral
    2244.2%
  • Poster
    5,13495.8%

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Unifying Stable Optimization and Reference Regularization in RLHF

Li He, Qiang Qu, He Zhao, Stephen Wan, Dadong Wang, Lina Yao, Tongliang Liu

展开摘要

Reinforcement Learning from Human Feedback (RLHF) has advanced alignment capabilities significantly but remains hindered by two core challenges: reward hacking and stable optimization. Current solutions independently address these issues through separate regularization strategies, specifically a KL-divergence penalty against a supervised fine-tuned model ($\pi_0$) to mitigate reward hacking, and policy ratio clipping towards the current policy ($\pi_t$) to promote stable alignment. However, the implicit trade-off arising from simultaneously regularizing towards both $\pi_0$ and $\pi_t$ remains under-explored. In this paper, we introduce a unified regularization approach that explicitly balances the objectives of preventing reward hacking and maintaining stable policy updates. Our simple yet principled alignment objective yields a weighted supervised fine-tuning loss with a superior trade-off, which demonstrably improves both alignment results and implementation complexity. Extensive experiments across diverse benchmarks validate that our method consistently outperforms RLHF and online preference learning methods, achieving enhanced alignment performance and stability.

Poster
Compute-Optimal Quantization-Aware Training

Aleksandr Dremov, David Grangier, Angelos Katharopoulos, Awni Hannun

展开摘要

Quantization-aware training (QAT) is a leading technique for improving the accuracy of quantized neural networks. Previous work has shown that decomposing training into a full-precision (FP) phase followed by a QAT phase yields superior accuracy compared to QAT alone. However, the optimal allocation of compute between the FP and QAT phases remains unclear. We conduct extensive experiments with various compute budgets, QAT bit widths, and model sizes from 86.0M to 2.2B to investigate how different QAT durations impact final performance. We demonstrate that, contrary to previous findings, the loss-optimal ratio of QAT to FP training increases with the total amount of compute. Moreover, the optimal fraction can be accurately predicted for a wide range of model sizes and quantization widths using the tokens-per-parameter-byte statistic. From experimental data, we derive a loss scaling law that predicts both optimal QAT ratios and final model performance across different QAT/FP compute allocation strategies and QAT bit widths. We use the scaling law to make further predictions, which we verify experimentally, including which QAT bit width is optimal under a given memory constraint and how QAT accuracy with different bit widths compares to full-precision model accuracy. Additionally, we propose a novel cooldown and QAT fusion approach that performs learning rate decay jointly with quantization-aware training, eliminating redundant full-precision model updates and achieving significant compute savings. These findings provide practical insights into efficient QAT planning and enable the training of higher-quality quantized models with the same compute budget.

Poster
WearVox: An Egocentric Multichannel Voice Assistant Benchmark for Wearables

Zhaojiang Lin, Yong Xu, Kai Sun, Jing Zheng, Yin Huang, Surya Teja Appini, Krish Narang, Renjie Tao, Ishan Kapil Jain, Siddhant Arora, Ruizhi Li, Yiteng Huang, Kaushik Patnaik, Wenfang Xu, Suwon Shon, Yue Liu, Ahmed A Aly, Anuj Kumar, Florian Metze, Xin Luna Dong

展开摘要

Wearable devices such as AI glasses are transforming voice assistants into always-available, hands-free collaborators that integrate seamlessly with daily life, but they also introduce challenges like egocentric audio affected by motion and noise, rapid micro-interactions, and the need to distinguish device-directed speech from background conversations. Existing benchmarks largely overlook these complexities, focusing instead on clean or generic conversational audio. To bridge this gap, we present WearVox, the first benchmark designed to rigorously evaluate voice assistants in realistic wearable scenarios. WearVox comprises 3,842 multi-channel, egocentric audio recordings collected via AI glasses across five diverse tasks including Search-Grounded QA, Closed-Book QA, Side-Talk Rejection, Tool Calling, and Speech Translation, spanning a wide range of indoor and outdoor environments and acoustic conditions. Each recording is accompanied by rich metadata, enabling nuanced analysis of model performance under real-world constraints. We benchmark leading proprietary and open-source speech Large Language Models (SLLMs) and find that most real-time SLLMs achieve accuracies on WearVox ranging from 29\% to 59\%, with substantial performance degradation on noisy outdoor audio, underscoring the difficulty and realism of the benchmark. Additionally, we conduct a case study with two new SLLMs that perform inference with single-channel and multi-channel audio, demonstrating that multi-channel audio inputs significantly enhance model robustness to environmental noise and improve discrimination between device-directed and background speech. Our results highlight the critical importance of spatial audio cues for context-aware voice assistants and establish WearVox as a comprehensive testbed for advancing wearable voice AI research.

Poster
VisionReasoner: Unified Reasoning-Integrated Visual Perception via Reinforcement Learning

Yuqi Liu, Tianyuan Qu, Zhisheng Zhong, Bohao PENG, Shu Liu, Bei Yu, Jiaya Jia

展开摘要

Large vision-language models exhibit inherent capabilities to handle diverse visual perception tasks. In this paper, we introduce VisionReasoner, a unified framework capable of reasoning and solving multiple visual perception tasks within a shared model. Specifically, by designing a unified reward mechanism and multi-object cognitive learning strategies, VisionReasoner enhances its reasoning capabilities to analyze visual inputs, and addresses diverse perception tasks within a unified model. VisionReasoner generates a structured reasoning process before delivering the desired outputs responding to user queries. Human evaluation reveals the reasoning process of VisionReasoner is faithful and reliable even without annotated reasoning train data. To rigorously assess unified visual perception capabilities, we evaluate VisionReasoner on ten diverse tasks spanning three critical domains: detection, segmentation, and counting. Experimental results show that VisionReasoner achieves superior performance as a unified model, outperforming the baseline Qwen2.5VL by relative margins of 29.1% on COCO (detection), 22.1% on ReasonSeg (segmentation), and 13.2% on CountBench (counting).

Poster
Virtual Community: An Open World for Humans, Robots, and Society

Qinhong Zhou, Hongxin Zhang, Xiangye Lin, Zheyuan Zhang, Yutian Chen, Wenjun Liu, Zunzhe Zhang, Sunli Chen, Lixing Fang, Qiushi Lyu, Xinyu Sun, Jincheng Yang, Zeyuan Wang, Bao Chi Dang, Zhehuan Chen, Daksha Ladia, Quang Vinh Dang, Jiageng Liu, Chuang Gan

展开摘要

The rapid progress of AI and robotics may profoundly transform society, as humans and robots begin to coexist in shared communities, bringing both opportunities and challenges. To explore this future, we present Virtual Community—an open-world platform for humans, robots, and society—built on a universal physics engine and grounded in real-world 3D scenes. With Virtual Community, we aim to enable the study of embodied social intelligence at scale. To support these, Virtual Community features: 1) An open-source multi-agent physics simulator that supports robot, human, and their interactions within a society; 2) A large‑scale, real‑world aligned environment generation pipeline, including vast outdoor space, diverse indoor scenes, and a community of grounded agents with rich characters and appearances. Leveraging Virtual Community, we propose two novel challenges. The Community Planning Challenge evaluates multi‑agent reasoning and planning in open‑world settings, such as cooperating to help agents with daily activities and efficiently connecting other agents. The Community Robot Challenge requires multiple heterogeneous robots to collaborate in solving complex open‑world tasks. We evaluate various baselines and demonstrate the challenges in both high‑level open‑world task planning and low‑level cooperation controls. We have open-sourced our project and hope that Virtual Community will unlock further study of human-robot coexistence in open worlds.

Poster
LORE: Jointly Learning The Intrinsic Dimensionality and Relative Similarity Structure from Ordinal Data

Vivek Anand, Alec Helbling, Mark A. Davenport, Gordon J Berman, Sankaraleengam Alagapan, Christopher John Rozell

展开摘要

Learning the intrinsic dimensionality of subjective perceptual spaces such as taste, smell, or aesthetics from ordinal data is a challenging problem. We introduce LORE (Low Rank Ordinal Embedding), a scalable framework that jointly learns both the intrinsic dimensionality and an ordinal embedding from noisy triplet comparisons of the form, "Is A more similar to B than C?". Unlike existing methods that require the embedding dimension to be set apriori, LORE regularizes the solution using the nonconvex Schatten-p quasi norm, enabling automatic joint recovery of both the ordinal embedding and its dimensionality. We optimize this joint objective via an iteratively reweighted algorithm and establish convergence guarantees. Extensive experiments on synthetic datasets, simulated perceptual spaces, and real world crowdsourced ordinal judgements show that LORE learns compact, interpretable and highly accurate low dimensional embeddings that recover the latent geometry of subjective percepts. By simultaneously inferring both the intrinsic dimensionality and ordinal embeddings, LORE enables more interpretable and data efficient perceptual modeling in psychophysics and opens new directions for scalable discovery of low dimensional structure from ordinal data in machine learning.

Poster
LaVCa: LLM-assisted Visual Cortex Captioning

Takuya Matsuyama, Shinji Nishimoto, Yu Takagi

展开摘要

Understanding the properties of neural populations (or voxels) in the human brain can advance our comprehension of human perceptual and cognitive processing capabilities and contribute to developing brain-inspired computer models. Recent encoding models using deep neural networks (DNNs) have successfully predicted voxel-wise activity. However, interpreting the properties that explain voxel responses remains challenging because of the black-box nature of DNNs. As a solution, we propose LLM-assisted Visual Cortex Captioning (LaVCa), a data-driven approach that leverages large language models (LLMs) to generate natural-language captions for images to which voxels are selective. By applying LaVCa for image-evoked brain activity, we demonstrate that LaVCa generates captions that describe voxel selectivity more accurately than the previous approaches. The captions generated by LaVCa quantitatively capture more detailed properties than the existing method at both the inter-voxel and intra-voxel levels. Furthermore, we find richer representational content within cortical regions that prior neuroimaging studies have deemed selective for simpler categories. These findings offer profound insights into human visual representations by assigning detailed captions throughout the visual cortex while highlighting the potential of LLM-based methods in understanding brain representations.

Poster
FullPart: Generating each 3D Part at Full Resolution

Lihe Ding, Shaocong Dong, Yaokun Li, Chenjian Gao, Xiao Chen, Rui Han, Yihao Kuang, Hong Zhang, Bo Huang, Zhanpeng Huang, Zibin Wang, Dan Xu, Tianfan Xue

展开摘要

Part-based 3D generation holds great potential for various applications. Previous part generators that represent parts using implicit vector-set tokens often suffer from insufficient geometric details. Another line of work adopts an explicit voxel representation but shares a global voxel grid among all parts; this often causes small parts to occupy too few voxels, leading to degraded quality. In this paper, we propose FullPart, a novel framework that combines both implicit and explicit paradigms. It first derives the bounding box layout through an implicit box vector-set diffusion process, a task that implicit diffusion handles effectively since box tokens contain little geometric detail. Then, it generates detailed parts, each within its own fixed full-resolution voxel grid. Instead of sharing a global low-resolution space, each part in our method—even small ones—is generated at full resolution, enabling the synthesis of intricate details. We further introduce a center-point encoding strategy to address the misalignment issue when exchanging information between parts of different actual sizes, thereby maintaining global coherence. Moreover, to tackle the scarcity of reliable part data, we present PartVerse-XL, the largest human-annotated 3D part dataset to date. Extensive experiments demonstrate that FullPart achieves state-of-the-art results in 3D part generation. We will release all code, data, and model to benefit future research in 3D part generation.

Poster
Retrospective Sparse Attention for Efficient Long-Context Generation

Seonghwan Choi, Beomseok Kang, Dongwon Jo, Jae-Joon Kim

展开摘要

Large Language Models (LLMs) are increasingly deployed in long-context tasks such as reasoning, code generation, and multi-turn dialogue. However, inference over extended contexts is bottlenecked by the Key-Value (KV) cache, whose memory footprint grows linearly with sequence length and dominates latency at each decoding step. While recent KV cache compression methods identify and load important few tokens, they focus predominantly on input contexts and fail to address the cumulative attention errors that arise during long decoding. In this paper, we introduce RetroAttention, a novel KV cache update technique that retrospectively revises past attention outputs using newly arrived KV entries from subsequent decoding steps. By maintaining a lightweight output cache, RetroAttention enables past queries to be efficiently supplemented with more contexts, while incurring minimal latency overhead. This breaks the fixed-attention-output paradigm and allows continual correction of prior approximations. Extensive experiments on long-generation benchmarks show that RetroAttention consistently outperforms state-of-the-art (SOTA) KV compression methods, increasing effective KV exposure by up to 1.6$\times$ and accuracy by up to 21.9\%. We provide anonymized code in the supplementary material.

Poster
DeepTRACE: Auditing Deep Research AI Systems for Tracking Reliability Across Citations and Evidence

Pranav Narayanan Venkit, Philippe Laban, Yilun Zhou, Kung-Hsiang Huang, Yixin Mao, Chien-Sheng Wu

展开摘要

Generative search engines and deep research LLM agents promise trustworthy, source-grounded synthesis, yet users regularly encounter overconfidence, weak sourcing, and confusing citation practices. We introduce DeepTRACE, a novel sociotechnically grounded audit framework that turns prior community-identified failure cases into eight measurable dimensions spanning answer text, sources, and citations. DeepTRACE uses statement-level analysis (decomposition, confidence scoring) and builds citation and factual-support matrices to audit how systems reason with and attribute evidence end-to-end. Using automated extraction pipelines for popular public models (e.g., GPT-4.5/5, You.com, Perplexity, Copilot/Bing, Gemini) and an LLM-judge with validated agreement to human raters, we evaluate both web-search engines and deep-research configurations. Our findings show that generative search engines and deep research agents frequently produce one-sided, highly confident responses on debate queries and include large fractions of statements unsupported by their own listed sources. Deep-research configurations reduce overconfidence and can attain high citation thoroughness, but they remain highly one-sided on debate queries and still exhibit large fractions of unsupported statements, with citation accuracy ranging from 40–80\% across systems.

Poster
ProSafePrune: Projected Safety Pruning for Mitigating Over-Refusal in LLMs

Zijun Chen, Wenbo Hu, Ya Li, Lei Miao, Guoping Hu, Richang Hong

展开摘要

Large Language Models (LLMs) excel in various domains, but their safe deployment faces the challenge of balancing safety and utility. Existing alignment strategies often strengthen refusal mechanisms to reduce harmful outputs, but harmless instructions with superficial risky words are mistakenly rejected, which is known as over-refusal. This work first reveals that over-refusal stems from a cognitive bias in the model's internal representation space: LLMs naturally encode safety attributes in hidden states, and pseudo-harmful instructions overlap with harmful features, causing over-harmful encoding. To address this, we propose ProSafePrune, a subspace-projected low-rank parameter pruning framework for mitigating LLM over-refusal. By projecting pseudo-harmful features into subspaces and removing low-rank directions corresponding to harmful components in the most discriminative layers, we significantly reduce over-refusal while preserving the model’s ability to reject genuinely harmful requests, improving performance on general tasks. In experiments, across different models, our method significantly lowers the average false rejection rate while slightly improving general task performance.

Poster
The Matthew Effect of AI Programming Assistants: A Hidden Bias in Software Evolution

Fei Gu, Zi Liang, Jiahao MA, Hongzong LI

展开摘要

AI-assisted programming is rapidly reshaping software development, with large language models (LLMs) enabling new paradigms such as vibe coding and agentic coding. While prior works have focused on prompt design and code generation quality, the broader impact of LLM-driven development on the iterative dynamics of software engineering remains underexplored. In this paper, we conduct large-scale experiments on thousands of algorithmic programming tasks and hundreds of framework selection tasks to systematically investigate how AI-assisted programming interacts with the software ecosystem. Our analysis quantifies a substantial performance asymmetry: mainstream languages and frameworks achieve significantly higher success rates than niche ones. This disparity suggests a feedback loop consistent with the Matthew Effect, where data-rich ecosystems gain superior AI support. While not the sole driver of adoption, current models introduce a non-negligible productivity friction for niche technologies, representing a hidden bias in software evolution.

Poster
TS-Attn: Temporal-wise Separable Attention for Multi-Event Video Generation

Hongyu Zhang, Yufan Deng, Zilin Pan, Peng-Tao Jiang, Bo Li, Qibin Hou, Zhen Dong, Zhiyang Dou, Daquan Zhou

展开摘要

Generating high-quality videos from complex temporal descriptions, which refer to prompts containing multiple sequential actions, remains a significant challenge. Existing methods are constrained by an inherent trade-off: using multiple short prompts fed sequentially into the model improves action fidelity but compromises temporal consistency, while a single complex prompt preserves consistency at the cost of prompt following capability. We attribute this problem to two primary causes: temporal misalignment between video content and the prompt, and conflicting attention coupling between motion-related visual objects and their associated text conditions. To address these challenges, we propose a novel, training-free attention mechanism, Temporal-wise Separable Attention (TS-Attn), which dynamically rearranges attention distribution to ensure temporal awareness and global coherence in multi-event scenarios. TS-Attn can be seamlessly integrated into various pre-trained text-to-video models, boosting StoryEval-Bench scores by 33.5% and 16.4% on Wan2.1-T2V-14B and Wan2.2-T2V-A14B with only a 2% increase in inference time. It also supports plug-and-play usage across models for multi-event image-to-video generation. The source code and video demos are available in the supplementary materials.

Poster
Safety Mirage: How Spurious Correlations Undermine VLM Safety Fine-Tuning and Can Be Mitigated by Machine Unlearning

Yiwei Chen, Yuguang Yao, Yihua Zhang, Bingquan Shen, Gaowen Liu, Sijia Liu

展开摘要

Recent vision language models (VLMs) have made remarkable strides in generative modeling with multimodal inputs, particularly text and images. However, their susceptibility to generating harmful content when exposed to unsafe queries raises critical safety concerns. While current alignment strategies primarily rely on supervised safety fine-tuning with curated datasets, we identify a fundamental limitation we call the "safety mirage", where supervised fine-tuning inadvertently reinforces spurious correlations between superficial textual patterns and safety responses, rather than fostering deep, intrinsic mitigation of harm. We show that these spurious correlations leave fine-tuned VLMs vulnerable even to a simple one-word modification-based attack, where substituting a single word in text queries with a spurious correlation-inducing alternative can effectively bypass safeguards. Additionally, these correlations contribute to the over-prudence, causing fine-tuned VLMs to refuse benign queries unnecessarily. To address these issues, we show machine unlearning (MU) as a powerful alternative to supervised safety fine-tuning, as it avoids biased feature-label mappings and directly removes harmful knowledge from VLMs while preserving their general capabilities. Extensive evaluations across safety benchmarks show that under MU-based alignment reduces the attack success rate by up to 60.27% and cuts unnecessary rejections by over 84.20%.

Poster
H2OFlow: Grounding Human-Object Affordances with 3D Generative Models and Dense Diffused Flows

Harry Zhang, Luca Carlone

展开摘要

Understanding how humans interact with the surrounding environment, and specifically reasoning about object interactions and affordances, is a critical challenge in computer vision, robotics, and AI. Current approaches often depend on labor-intensive, hand-labeled datasets capturing real-world or simulated human-object interaction (HOI) tasks, which are costly and time-consuming to produce. Furthermore, most existing methods for 3D affordance understanding are limited to contact-based analysis, neglecting other essential aspects of human-object interactions, such as orientation (e.g., humans might have a preferential orientation with respect certain objects, such as a TV) and spatial occupancy (e.g., humans are more likely to occupy certain regions around an object, like the front of a microwave rather than its back). To address these limitations, we introduce **H2OFlow**, a novel framework that comprehensively learns 3D HOI affordances ---encompassing contact, orientation, and spatial occupancy--- using only synthetic data generated from 3D generative models. H2OFlow employs a dense 3D-flow-based representation, learned through a dense diffusion process operating on point clouds. This learned flow enables the discovery of rich 3D affordances without the need for human annotations. Through extensive quantitative and qualitative evaluations, we demonstrate that H2OFlow generalizes effectively to real-world objects and surpasses prior methods that rely on manual annotations or mesh-based representations in modeling 3D affordance.

Poster
NarrLV: Towards a Comprehensive Narrative-Centric Evaluation for Long Video Generation

Xiaokun Feng, Haiming Yu, Meiqi Wu, Shiyu Hu, Jintao Chen, Chen Zhu, Jiahong Wu, Xiangxiang Chu, Kaiqi Huang

展开摘要

With the rapid development of foundation video generation technologies, long video generation models have exhibited promising research potential thanks to expanded content creation space. Recent studies reveal that the goal of long video generation tasks is not only to extend video duration but also to accurately express richer narrative content within longer videos. However, due to the lack of evaluation benchmarks specifically designed for long video generation models, the current assessment of these models primarily relies on benchmarks with simple narrative prompts (e.g., VBench). To the best of our knowledge, our proposed NarrLV is the first benchmark to comprehensively evaluate the Narrative expression capabilities of Long Video generation models. Inspired by film narrative theory, (i) we first introduce the basic narrative unit maintaining continuous visual presentation in videos as Temporal Narrative Atom (TNA), and use its count to quantitatively measure narrative richness. Guided by three key film narrative elements influencing TNA changes, we construct an automatic prompt generation pipeline capable of producing evaluation prompts with a flexibly expandable number of TNAs. (ii) Then, based on the three progressive levels of narrative content expression, we design an effective evaluation metric using the MLLM-based question generation and answering framework. (iii) Finally, we conduct extensive evaluations on existing long video generation models and the foundation generation models that underpin them. Experimental results demonstrate that our metric aligns closely with human judgments. The derived evaluation outcomes reveal the detailed capability boundaries of current video generation models in narrative content expression.

Poster
SocialJax: An Evaluation Suite for Multi-agent Reinforcement Learning in Sequential Social Dilemmas

Zihao Guo, Shuqing Shi, Richard Willis, Tristan Tomilin, Joel Z Leibo, Yali Du

展开摘要

Sequential social dilemmas pose a significant challenge in the field of multi-agent reinforcement learning (MARL), requiring environments that accurately reflect the tension between individual and collective interests. Previous benchmarks and environments, such as Melting Pot, provide an evaluation protocol that measures generalization to new social partners in various test scenarios. However, running reinforcement learning algorithms in traditional environments requires substantial computational resources. In this paper, we introduce SocialJax, a suite of sequential social dilemma environments and algorithms implemented in JAX. JAX is a high-performance numerical computing library for Python that enables significant improvements in operational efficiency. Our experiments demonstrate that the SocialJax training pipeline achieves at least 50\texttimes{} speed-up in real-time performance compared to Melting Pot’s RLlib baselines. Additionally, we validate the effectiveness of baseline algorithms within SocialJax environments. Finally, we use Schelling diagrams to verify the social dilemma properties of these environments, ensuring that they accurately capture the dynamics of social dilemmas.

Poster
Parameterization-Based Dataset Distillation of 3D Point Clouds through Learnable Shape Morphing

DongWook Kim, Jae-Young Yim, Jae-Young Sim

展开摘要

Recent attempt in dataset distillation has been made to compress large-scale training datasets into compact synthetic versions, significantly reducing memory usage and training costs. While parameterization-based approaches have shown promising results on image datasets, their application to 3D point clouds remains largely unexplored due to the irregular and unordered nature of 3D data. In this paper, we first introduce a parameterization-based dataset distillation framework for 3D point clouds that enables the use of more diverse synthetic samples than conventional methods under the same memory budget. We first construct an initial synthetic dataset containing multiple anchor samples with a coarser resolution than the original sample. We also generate new samples by morphing the shapes of the anchor samples with learnable weights to improve the diversity of synthetic dataset. Moreover, we devise a uniformity-aware matching loss to ensure the structural consistency when comparing the original and synthetic datasets. Extensive experiments conducted on five standard benchmarks—ModelNet10, ModelNet40, ShapeNet, ScanObjectNN, and OmniObject3D—demonstrate that the proposed method effectively optimizes both the synthetic samples and the weights for shape morphing, outperforming existing dataset distillation methods.

Poster
Refine Drugs, Don’t Complete Them: Uniform-Source Discrete Flows for Fragment-Based Drug Discovery

Benno Kaech, Luis Wyss, Karsten Borgwardt, Gianvito Grasso

展开摘要

We introduce InVirtuoGen, a discrete flow generative model for fragmented SMILES for de novo and fragment-constrained generation, and target-property/lead optimization of small molecules. The model learns to transform a uniform source over all possible tokens into the data distribution. Unlike masked models, its training loss accounts for predictions on all sequence positions at every denoising step, shifting the generation paradigm from completion to refinement, and decoupling the number of sampling steps from the sequence length. For \textit{de novo} generation, InVirtuoGen achieves a stronger quality-diversity pareto frontier than prior fragment-based models and competitive performance on fragment-constrained tasks. For property and lead optimization, we propose a hybrid scheme that combines a genetic algorithm with a Proximal Property Optimization fine-tuning strategy adapted to discrete flows. Our approach sets a new state-of-the-art on the Practical Molecular Optimization benchmark, measured by top-10 AUC across tasks, and yields higher docking scores in lead optimization than previous baselines. InVirtuoGen thus establishes a versatile generative foundation for drug discovery, from early hit finding to multi-objective lead optimization. We further contribute to open science by releasing pretrained checkpoints and code, making our results fully reproducible.

Poster
S3OD: Towards Generalizable Salient Object Detection with Synthetic Data

Orest Kupyn, Hirokatsu Kataoka, Christian Rupprecht

展开摘要

Salient object detection exemplifies data-bounded tasks where expensive pixel-precise annotations force separate model training for related subtasks like DIS and HR-SOD. We present a method that dramatically improves generalization through large-scale synthetic data generation and ambiguity-aware architecture. We introduce S3OD, a dataset of over 139,000 high-resolution images created through our multi-modal diffusion pipeline that extracts labels from diffusion and DINO-v3 features. The iterative generation framework prioritizes challenging categories based on model performance. We propose a streamlined multi-mask decoder that handles the inherent ambiguity in salient object detection by predicting multiple valid interpretations. Models trained only on synthetic data achieve 20-50% error reduction in cross-dataset generalization, while fine-tuned versions reach state-of-the-art performance across DIS and HR-SOD benchmarks.

Poster