NeurIPS 2025 Papers

Fluorescence microscopy, while being a key driver for progress in the life sciences, is also subject to technical limitations. To overcome them, computational multiplexing techniques have recently been proposed, which allow multiple cellular structures to be captured in a single image and later be unmixed. Existing image decomposition methods are trained on a set of superimposed input images and the respective unmixed target images. It is critical to note that the relative strength (mixing ratio) of the superimposed images for a given input is a priori unknown. However, existing methods are trained on a fixed intensity ratio of superimposed inputs, making them not cognizant of the range of relative intensities that can occur in fluorescence microscopy. In this work, we propose a novel method called scSplit that is cognizant of the severity of the above-mentioned mixing ratio. Our idea is based on InDI, a popular iterative method for image restoration, and an ideal starting point to embrace the unknown mixing ratio in any given input. We introduce (i) a suitably trained regressor network that predicts the degradation level (mixing asymmetry) of a given input image and (ii) a degradation-specific normalization module, enabling degradation-aware inference across all mixing ratios. We show that this method solves two relevant tasks in fluorescence microscopy, namely image splitting and bleedthrough removal, and empirically demonstrate the applicability of scSplit on 5 public datasets. The source code with pre-trained models is hosted at https://github.com/juglab/scSplit/.

Ultra-high dynamic range (UHDR) scenes exhibit pronounced exposure disparities between bright and dark regions. Such conditions are Ultra-high dynamic range (UHDR) scenes exhibit significant exposure disparities between bright and dark regions. Such conditions are commonly encountered in nighttime scenes with light sources. Even with standard exposure settings, a bimodal intensity distribution with boundary peaks often emerges, making it difficult to preserve both highlight and shadow details simultaneously. RGB-based bracketing methods can capture details at both ends using short-long exposure pairs, but are susceptible to misalignment and ghosting artifacts. We found that a short-exposure image already retains sufficient highlight detail. The main challenge of UHDR reconstruction lies in denoising and recovering information in dark regions. In comparison to the RGB images, RAW images, thanks to their higher bit depth and more predictable noise characteristics, offer greater potential for addressing this challenge. This raises a key question: can we learn to see everything in UHDR scenes using only a single short-exposure RAW image? In this study, we rely solely on a single short-exposure frame, which inherently avoids ghosting and motion blur, making it particularly robust in dynamic scenes. To achieve that, we introduce UltraLED, a two-stage framework that performs exposure correction via a ratio map to balance dynamic range, followed by a brightness-aware RAW denoiser to enhance detail recovery in dark regions. To support this setting, we design a 9-stop bracketing pipeline to synthesize realistic UHDR images and contribute a corresponding dataset based on diverse scenes, using only the shortest exposure as input for reconstruction. Extensive experiments show that UltraLED significantly outperforms existing single-frame approaches. Our code and dataset are made publicly available at https://srameo.github.io/projects/ultraled.

The quality of the video dataset (image quality, resolution, and fine-grained caption) greatly influences the performance of the video generation model. % The growing demand for video applications sets higher requirements for high-quality video generation models. % For example, the generation of movie-level Ultra-High Definition (UHD) videos and the creation of 4K short video content. % However, the existing public datasets cannot support related research and applications. % In this paper, we first propose a high-quality open-sourced UHD-4K (22.4\% of which are 8K) text-to-video dataset named UltraVideo, which contains a wide range of topics (more than 100 kinds), and each video has 9 structured captions with one summarized caption (average of 824 words). % Specifically, we carefully design a highly automated curation process with four stages to obtain the final high-quality dataset: ***i)*** collection of diverse and high-quality video clips. ***ii*** statistical data filtering. ***iii)*** model-based data purification. ***iv)*** generation of comprehensive, structured captions. % In addition, we expand Wan to UltraWan-1K/-4K, which can natively generate high-quality 1K/4K videos with more consistent text controllability, demonstrating the effectiveness of our data curation. % We believe that this work can make a significant contribution to future research on UHD video generation. UltraVideo dataset and UltraWan models are available at https://xzc-zju.github.io/projects/UltraVideo.

Image stitching synthesizes images captured from multiple perspectives into a single image with a broader field of view. The significant variations in object depth often lead to large parallax, resulting in ghosting and misalignment in the stitched results. To address this, we propose a depth-consistency-constrained seamless-free image stitching method. First, to tackle the multi-view alignment difficulties caused by parallax, a multi-stage mechanism combined with global depth regularization constraints is developed to enhance the alignment accuracy of the same apparent target across different depth ranges. Second, during the multi-view image fusion process, an optimal stitching seam is determined through graph-based low-cost computation, and a soft-seam region is diffused to precisely locate transition areas, thereby effectively mitigating alignment errors induced by parallax and achieving natural and seamless stitching results. Furthermore, considering the computational overhead in the shift regression process, a reparameterization strategy is incorporated to optimize the structural design, significantly improving algorithm efficiency while maintaining optimal performance. Extensive experiments demonstrate the superior performance of the proposed method against the existing methods. Code is available at https://github.com/DLUT-YRH/DSFN.

To improve detection robustness in adverse conditions (e.g., haze and low light), image restoration is commonly applied as a pre-processing step to enhance image quality for the detector. However, the functional mismatch between restoration and detection networks can introduce instability and hinder effective integration---an issue that remains underexplored. We revisit this limitation through the lens of Lipschitz continuity, analyzing the functional differences between restoration and detection networks in both the input space and the parameter space. Our analysis shows that restoration networks perform smooth, continuous transformations, while object detectors operate with discontinuous decision boundaries, making them highly sensitive to minor perturbations. This mismatch introduces instability in traditional cascade frameworks, where even imperceptible noise from restoration is amplified during detection, disrupting gradient flow and hindering optimization. To address this, we propose Lipschitz-regularized object detection (LROD), a simple yet effective framework that integrates image restoration directly into the detector’s feature learning, harmonizing the Lipschitz continuity of both tasks during training. We implement this framework as Lipschitz-regularized YOLO (LR-YOLO), extending seamlessly to existing YOLO detectors. Extensive experiments on haze and low-light benchmarks demonstrate that LR-YOLO consistently improves detection stability, optimization smoothness, and overall accuracy.

The effectiveness of domain translation in addressing image-based problems of Unsupervised Domain Adaptation (UDA) depends on the quality of the translated images and the preservation of crucial discriminative features. However, achieving high-quality and stable translations typically requires paired data, which poses a challenge in scenarios with limited annotations in the target domain. To address this issue, this paper proposes a novel method termed Stain-Guided Cycle Diffusion (SGCD), employing a dual diffusion model with bidirectional generative constraints to synthesize highly realistic data for downstream task fine-tuning. The bidirectional generative constraints ensure that the translated images retain the features critical to the downstream model in properly controlling the generation process. Additionally, a stain-guided consistency loss is introduced to enhance the denoising capability of the dual diffusion model, thereby improving the quality of images translated between different domains using latents from one domain and a diffusion model trained on another. Experiments conducted on four public datasets demonstrate that SGCD can effectively enhance the performance of downstream task models on the target domain.

There is growing interest in integrating high-fidelity visual synthesis capabilities into large language models (LLMs) without compromising their strong reasoning capabilities. Existing methods that directly train LLMs or bridge LLMs and diffusion models usually suffer from costly training since the backbone LLMs have not seen image representations during pretraining. We present Bifrost-1, a unified framework that bridges pretrained multimodal LLMs (MLLMs) and diffusion models using patch-level CLIP image embeddings as latent variables, which are natively aligned with the MLLM's CLIP visual encoder. These patch-level image embeddings are integrated into the diffusion model with a lightweight adaptation of its ControlNet. To retain the original multimodal reasoning capabilities of MLLMs, we equip the MLLM with a visual generation branch initialized from the original MLLM parameters when predicting the patch-level image embeddings. By seamlessly integrating pretrained MLLMs and diffusion models with patch-level CLIP latents, our framework enables high-fidelity controllable image generation with significant training efficiency. Our experiments demonstrate that Bifrost-1 achieves comparable or better performance than previous methods in terms of visual fidelity and multimodal understanding, with substantially lower compute during training. We also provide comprehensive ablation studies showing the effectiveness of our design choices. Project page: https://bifrost-1.github.io.

Diffusion Transformers (DiTs) have recently demonstrated remarkable performance in visual generation tasks, surpassing traditional U-Net-based diffusion models by significantly improving image and video generation quality and scalability. However, the large model size and iterative denoising process introduce substantial computational and memory overhead, limiting their deployment in real-world applications. Post-training quantization (PTQ) is a promising solution that compresses models and accelerates inference by converting weights and activations to low-bit representations. Despite its potential, PTQ faces significant challenges when applied to DiTs, often resulting in severe degradation of generative quality. To address these issues, we propose VETA-DiT (**V**ariance-**E**qualized and **T**emporal **A**daptation for **Di**ffusion **T**ransformers), a dedicated quantization framework for DiTs. Our method first analyzes the sources of quantization error from the perspective of inter-channel variance and introduces a Karhunen–Loève Transform enhanced alignment to equalize variance across channels, facilitating effective quantization under low bit-widths. Furthermore, to handle the temporal variation of activation distributions inherent in the iterative denoising steps of DiTs, we design an incoherence-aware adaptive method that identifies and properly calibrates timesteps with high quantization difficulty. We validate VETA-DiT on extensive image and video generation tasks, preserving acceptable visual quality under the more aggressive W4A4 configuration. Specifically, VETA-DiT reduces FID by 33.65 on the DiT-XL/2 model and by 45.76 on the PixArt-$\Sigma$ model compared to the baseline under W4A4, demonstrating its strong quantization capability and generative performance. Code is available at: https://github.com/xululi0223/VETA-DiT.

A central challenge in language models (LMs) is faithfulness hallucination: the generation of information unsubstantiated by input context. To study this problem, we propose Precise Information Control (PIC), a new task formulation that requires models to generate long-form outputs grounded in a provided set of short self-contained statements, without adding any unsupported ones. PIC includes a full setting that tests a model’s ability to include exactly all input claims, and a partial setting that requires the model to selectively incorporate only relevant claims. We present PIC-Bench, a benchmark of eight long-form generation tasks (e.g., summarization, biography generation) adapted to the PIC setting, where LMs are supplied with well-formed, verifiable input claims. Our evaluation of a range of open and proprietary LMs on PIC-Bench reveals that, surprisingly, state-of-the-art LMs still hallucinate against user-provided input in over 70% of generations. To alleviate this lack of faithfulness, we introduce a post-training framework that uses a weakly supervised preference data construction method to train an 8B PIC-LM with stronger PIC ability—improving from 69.1% to 91.0% F1 in the full PIC setting. When integrated into end-to-end factual generation pipelines, PIC-LM improves exact match recall by 17.1% on ambiguous QA with retrieval, and factual precision by 30.5% on a birthplace fact-checking task, underscoring the potential of precisely grounded generation.

Evaluating natural language generation (NLG) systems remains a core challenge, further complicated by the rise of general-purpose large language models (LLMs). Recently, large language models as judges (LLJs) have emerged as a scalable, cost-effective alternative to traditional metrics, but their validity remains underexplored. This position paper argues that the current enthusiasm around LLJs may be premature, as their adoption has outpaced rigorous scrutiny of their reliability and validity as evaluators. Drawing on measurement theory from the social sciences, we identify and critically assess four core assumptions underlying the use of LLJs: their ability to act as proxies for human judgment, their capabilities as evaluators, their scalability, and their cost-effectiveness. We examine how each of these assumptions may be challenged by the inherent limitations of LLMs, LLJs, or current practices in NLG evaluation. To ground our analysis, we explore three applications of LLJs at various stages of the machine learning pipeline: text summarization, data annotation and safety alignment. Finally, we highlight the need for more responsible evaluation practices in LLJs evaluation, to ensure that their growing role in the field supports, rather than undermines, progress in NLG.

Image-to-video generation has made remarkable progress with the advancements in diffusion models, yet generating videos with realistic motion remains highly challenging. This difficulty arises from the complexity of accurately modeling motion, which involves capturing physical constraints, object interactions, and domain-specific dynamics that are not easily generalized across diverse scenarios. To address this, we propose MotionRAG, a retrieval-augmented framework that enhances motion realism by adapting motion priors from relevant reference videos through Context-Aware Motion Adaptation (CAMA). The key technical innovations include: (i) a retrieval-based pipeline extracting high-level motion features using video encoder and specialized resamplers to distill semantic motion representations; (ii) an in-context learning approach for motion adaptation implemented through a causal transformer architecture; (iii) an attention-based motion injection adapter that seamlessly integrates transferred motion features into pretrained video diffusion models. Extensive experiments demonstrate that our method achieves significant improvements across multiple domains and various base models, all with negligible computational overhead during inference. Furthermore, our modular design enables zero-shot generalization to new domains by simply updating the retrieval database without retraining any components. This research enhances the core capability of video generation systems by enabling the effective retrieval and transfer of motion priors, facilitating the synthesis of realistic motion dynamics.

Classifier-Free Guidance (CFG) is an essential component of text-to-image diffusion models, and understanding and advancing its operational mechanisms remains a central focus of research. Existing approaches stem from divergent theoretical interpretations, thereby limiting the design space and obscuring key design choices. To address this, we propose a unified perspective that reframes conditional guidance as fixed point iterations, seeking to identify a golden path where latents produce consistent outputs under both conditional and unconditional generation. We demonstrate that CFG and its variants constitute a special case of single-step short-interval iteration, which is theoretically proven to exhibit inefficiency. To this end, we introduce Foresight Guidance (FSG), which prioritizes solving longer-interval subproblems in early diffusion stages with increased iterations. Extensive experiments across diverse datasets and model architectures validate the superiority of FSG over state-of-the-art methods in both image quality and computational efficiency. Our work offers novel perspectives for conditional guidance and unlocks the potential of adaptive design.

This paper introduces MetaDefense, a novel framework for defending against finetuning-based jailbreak attacks in large language models (LLMs). We observe that existing defense mechanisms fail to generalize to harmful queries disguised by unseen attack templates, despite LLMs being capable of distinguishing disguised harmful queries in the embedding space. Based on these insights, we propose a two-stage defense approach: (i) pre-generation defense that detects harmful queries before response generation begins, and (ii) mid-generation defense that monitors partial responses during generation to prevent outputting more harmful content. Our MetaDefense trains the LLM to predict the harmfulness of both queries and partial responses using specialized prompts, enabling early termination of potentially harmful interactions. Extensive experiments across multiple LLM architectures (LLaMA-2-7B, Qwen-2.5-3B-Instruct, and LLaMA-3.2-3B-Instruct) demonstrate that MetaDefense significantly outperforms existing defense mechanisms, achieving robust defense against harmful queries with seen and unseen attack templates while maintaining competitive performance on benign tasks. Code is available at [https://github.com/ws-jiang/MetaDefense](https://github.com/ws-jiang/MetaDefense).

Recent years have seen a surge in interest in digital content watermarking techniques, driven by the proliferation of generative models and increased legal pressure. With an ever-growing percentage of AI-generated content available online, watermarking plays an increasingly important role in ensuring content authenticity and attribution at scale. There have been many works assessing the robustness of watermarking to removal attacks, yet, watermark forging, the scenario when a watermark is stolen from genuine content and applied to malicious content, remains underexplored. In this work, we investigate watermark forging in the context of widely used post-hoc image watermarking. Our contributions are as follows. First, we introduce a preference model to assess whether an image is watermarked. The model is trained using a ranking loss on purely procedurally generated images without any need for real watermarks. Second, we demonstrate the model's capability to remove and forge watermarks by optimizing the input image through backpropagation. This technique requires only a single watermarked image and works without knowledge of the watermarking model, making our attack much simpler and more practical than attacks introduced in related work. Third, we evaluate our proposed method on a variety of post-hoc image watermarking models, demonstrating that our approach can effectively forge watermarks, questioning the security of current watermarking approaches. Our code and further resources are publicly available.

Aircraft manufacturing is the jewel in the crown of industry, in which generating high-fidelity airfoil geometries with controllable and editable representations remains a fundamental challenge. Existing deep learning methods, which typically rely on predefined parametric representations (e.g., Bézier curves) or discrete point sets, face an inherent trade-off between expressive power and resolution adaptability. To tackle this challenge, we introduce FuncGenFoil, a novel function-space generative model that directly reconstructs airfoil geometries as function curves. Our method inherits the advantages of arbitrary-resolution sampling and smoothness from parametric functions, as well as the strong expressiveness of discrete point-based representations. Empirical evaluations demonstrate that FuncGenFoil improves upon state-of-the-art methods in airfoil generation, achieving a relative 74.4% reduction in label error and a 23.2% increase in diversity on the AF-200K dataset. Our results highlight the advantages of function-space modeling for aerodynamic shape optimization, offering a powerful and flexible framework for high-fidelity airfoil design.

Image watermarking embeds imperceptible signals into AI-generated images for deepfake detection and provenance verification. Although recent semantic-level watermarking methods demonstrate strong resistance against conventional pixel-level removal attacks, their robustness against more advanced removal strategies remains underexplored, raising concerns about their reliability in practical scenarios. Existing removal attacks primarily operate in the pixel domain without altering image semantics, which limits their effectiveness against semantic-level watermarks. In this paper, we propose Next Frame Prediction Attack (NFPA), the first semantic-level removal attack. Unlike pixel-level attacks, NFPA formulates watermark removal as a video generation task: it treats the watermarked image as the initial frame and aims to subtly manipulate the image semantics to generate the next-frame image, i.e., the unwatermarked image. We conduct a comprehensive evaluation on eight state-of-the-art image watermarking schemes, demonstrating that NFPA consistently outperforms thirteen removal attack baselines in terms of the trade-off between watermark removal and image quality. Our results reveal the vulnerabilities of current image watermarking methods and highlight the urgent need for more robust watermarks.

Synthetic data generation in histopathology faces unique challenges: preserving tissue heterogeneity, capturing subtle morphological features, and scaling to unannotated datasets. We present a latent diffusion model that generates realistic heterogeneous histopathology images through a novel dual-conditioning approach combining semantic segmentation maps with tissue-specific visual crops. Unlike existing methods that rely on text prompts or abstract visual embeddings, our approach preserves critical morphological details by directly incorporating raw tissue crops from corresponding semantic regions. For annotated datasets (i.e., Camelyon16, Panda), we extract patches ensuring 20-80% tissue heterogeneity. For unannotated data (i.e., TCGA), we introduce a self-supervised extension that clusters whole-slide images into 100 tissue types using foundation model embeddings, automatically generating pseudo-semantic maps for training. Our method synthesizes high-fidelity images with precise region-wise annotations, achieving superior performance on downstream segmentation tasks. When evaluated on annotated datasets, models trained on our synthetic data show competitive performance to those trained on real data, demonstrating the utility of controlled heterogeneous tissue generation. In quantitative evaluation, prompt‐guided synthesis reduces Fréchet Distance by up to 6× on Camelyon16 (from 430.1 to 72.0) and yields 2–3× lower FD across Panda and TCGA. Downstream DeepLabv3+ models trained solely on synthetic data attain test IoU of 0.71 and 0.95 on Camelyon16 and Panda, within 1–2% of real‐data baselines (0.72 and 0.96). By scaling to 11,765 TCGA whole‐slide images without manual annotations, our framework offers a practical solution for an urgent need for generating diverse, annotated histopathology data, addressing a critical bottleneck in computational pathology.

In the field of computer vision, the task of stereo image super-resolution (StereoSR) has garnered significant attention due to its potential applications in augmented reality, virtual reality, and autonomous driving. Traditional Transformer-based models, while powerful, often suffer from attention noise, leading to suboptimal reconstruction issues in super-resolved images. This paper introduces DIFFSSR, a novel neural network architecture designed to address these challenges. We introduce the Diff Cross Attention Block (DCAB) and the Sliding Stereo Cross-Attention Module (SSCAM) to enhance feature integration and mitigate the impact of attention noise. The DCAB differentiates between relevant and irrelevant context, amplifying attention to important features and canceling out noise. The SSCAM, with its sliding window mechanism and disparity-based attention, adapts to local variations in stereo images, preserving details, and addressing the performance degradation due to misalignment of horizontal epipolar lines in stereo images. Extensive experiments on benchmark datasets demonstrate that DIFFSSR outperforms state-of-the-art methods, including NAFSSR and SwinFIRSSR, in terms of both quantitative metrics and visual quality.

Event cameras are neuromorphic vision sensors that asynchronously capture pixel-level intensity changes with high temporal resolution and dynamic range. These make them well suited for monocular depth estimation under challenging lighting conditions. However, progress in event-based monocular depth estimation remains constrained by the quality of supervision: LiDAR-based depth labels are inherently sparse, spatially incomplete, and prone to artifacts. Consequently, these signals are suboptimal for learning dense depth from sparse events. To address this problem, we propose Distil-E2D, a framework that distills depth priors from the image domain into the event domain by generating dense synthetic pseudolabels from co-recorded APS or RGB frames using foundational depth models. These pseudolabels complement sparse LiDAR depths with dense semantically rich supervision informed by large-scale image-depth datasets. To reconcile discrepancies between synthetic and real depths, we introduce a Confidence-Guided Calibrated Depth Loss that learns nonlinear depth alignment and adaptively weights supervision by alignment confidence. Additionally, our architecture integrates past predictions via a Context Transformer and employs a Dual-Decoder Training scheme that enhances encoder representations by jointly learning metric and relative depth abstractions. Experiments on benchmark datasets show that Distil-E2D achieves state-of-the-art performance in event-based monocular depth estimation across both event-only and event+APS settings.