NeurIPS 2025 Papers

Conference on Neural Information Processing Systems

Decision breakdown

5,812papers

Counted from the official paper list; may differ slightly from the number the conference announced.

  • Oral
    931.6%
  • Spotlight
    73912.7%
  • Poster
    4,98085.7%

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Topic: Multimodal LLMs · 1,074 papers · Reset filters

A TRIANGLE Enables Multimodal Alignment Beyond Cosine Similarity

Giordano Cicchetti, Eleonora Grassucci, Danilo Comminiello

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Multimodal learning plays a pivotal role in advancing artificial intelligence systems by incorporating information from multiple modalities to build a more comprehensive representation. Despite its importance, current state-of-the-art models still suffer from severe limitations that prevent the successful development of a fully multimodal model. Such methods do not provide indicators that all the involved modalities are effectively aligned. As a result, a set of modalities may not be aligned, undermining the effectiveness of the model in downstream tasks where multiple modalities should provide additional information that the model fails to exploit. In this paper, we present TRIANGLE: TRI-modAl Neural Geometric LEarning, the novel proposed similarity measure that is directly computed in the higher-dimensional space spanned by the modality embeddings. TRIANGLE improves the joint alignment of three modalities via a triangle‑area similarity, avoiding additional fusion layers. When incorporated in contrastive losses replacing cosine similarity, TRIANGLE significantly boosts the performance of multimodal modeling, while yielding interpretable alignment rationales. Extensive evaluation in three-modal tasks such as video-text and audio-text retrieval or audio-video classification, demonstrates that TRIANGLE achieves state-of-the-art results across different datasets improving the performance of cosine-based methods up to 9 points of Recall@1.

Poster
HBLLM: Wavelet-Enhanced High-Fidelity 1-Bit Quantization for LLMs

Ningning CHEN, Weicai Ye, Ying Jiang

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We introduce HBLLM, a wavelet-enhanced high-fidelity $1$-bit post-training quantization method for Large Language Models (LLMs). By leveraging Haar wavelet transforms to enhance expressive capacity through frequency decomposition, HBLLM significantly improves quantization fidelity while maintaining minimal overhead. This approach features two innovative structure-aware grouping strategies: (1) frequency-aware multi-parameter intra-row grouping and (2) $\ell_2$-norm-based saliency-driven column selection. For non-salient weights, a shared mean is employed across quantization groups within each frequency band to optimize storage efficiency. Experiments conducted on the OPT and LLaMA models demonstrate that HBLLM achieves state-of-the-art performance in $1$-bit quantization, attaining a perplexity of $6.71$ on LLaMA$2$-$13$B with an average weight storage of only $1.08$ bits. Code available at: https://github.com/Yeyke/HBLLM.

Spotlight
Intend to Move: A Multimodal Dataset for Intention-Aware Human Motion Understanding

Ryo Umagami, Liu Yue, Xuangeng Chu, Ryuto Fukushima, Tetsuya Narita, YUSUKE Mukuta, Tomoyuki Takahata, Jianfei Yang, Tatsuya Harada

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Human motion is inherently intentional, yet most motion modeling paradigms focus on low-level kinematics, overlooking the semantic and causal factors that drive behavior. Existing datasets further limit progress: they capture short, decontextualized actions in static scenes, providing little grounding for embodied reasoning. To address these limitations, we introduce $\textit{Intend to Move (I2M)}$, a large-scale, multimodal dataset for intention-grounded motion modeling. I2M contains 10.1 hours of two-person 3D motion sequences recorded in dynamic realistic home environments, accompanied by multi-view RGB-D video, 3D scene geometry, and language annotations of each participant’s evolving intentions. Benchmark experiments reveal a fundamental gap in current motion models: they fail to translate high-level goals into physically and socially coherent motion. I2M thus serves not only as a dataset but as a benchmark for embodied intelligence, enabling research on models that can reason about, predict, and act upon the ``why'' behind human motion.

Poster
CURV: Coherent Uncertainty-Aware Reasoning in Vision-Language Models for X-Ray Report Generation

Ziao Wang, Sixing Yan, Kejing Yin, Xiaofeng Zhang, William K. Cheung

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Vision-language models have been explored for radiology report generation with promising results. Yet, uncertainty elaborated in findings and the reasoning process for reaching clinical impressions are seldom explicitly modeled, reducing the clinical accuracy and trustworthiness of the generated reports. We present CURV, a novel framework that alleviates the limitations through integrated awareness of uncertainty and explicit reasoning capabilities. Our approach consists of three key components: (1) an uncertainty modeling mechanism that teaches the model to recognize and express appropriate levels of diagnostic confidence, (2) a structured reasoning framework that generates intermediate explanatory steps connecting visual findings to clinical impressions, and (3) a reasoning coherence reward that ensures logical consistency among findings, reasoning, and impressions. We implement CURV through a three-stage training pipeline that combines uncertainty-aware fine-tuning, reasoning initialization, and reinforcement learning. In particular, we adopt a comprehensive reward function addresses multiple aspects of report quality, incorporating medical term matching, uncertainty expression evaluation, and semantic coherence evaluation. Experimental results demonstrate that CURV generates clinically relevant reports with appropriate uncertainty expressions and transparent reasoning traces, significantly outperforming previous methods. CURV represents a substantial advancement toward interpretable and trustworthy AI-generated radiology reports, with broader implications for the deployment of vision-language models in high-stakes clinical environments where uncertainty awareness and reasoning transparency are essential.

Poster
UniPixel: Unified Object Referring and Segmentation for Pixel-Level Visual Reasoning

Ye Liu, Zongyang Ma, Junfu Pu, Zhongang Qi, Yang Wu, Ying Shan, Chang Wen Chen

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Recent advances in Large Multi-modal Models (LMMs) have demonstrated their remarkable success as general-purpose multi-modal assistants, with particular focuses on holistic image- and video-language understanding. Conversely, less attention has been given to scaling fine-grained pixel-level understanding capabilities, where the models are expected to realize pixel-level alignment between visual signals and language semantics. Some previous studies have applied LMMs to related tasks such as region-level captioning and referring expression segmentation. However, these models are limited to performing either referring or segmentation tasks independently and fail to integrate these fine-grained perception capabilities into visual reasoning. To bridge this gap, we propose UniPixel, a large multi-modal model capable of flexibly comprehending visual prompt inputs and generating mask-grounded responses. Our model distinguishes itself by seamlessly integrating pixel-level perception with general visual understanding capabilities. Specifically, UniPixel processes visual prompts and generates relevant masks on demand, and performs subsequent reasoning conditioning on these intermediate pointers during inference, thereby enabling fine-grained pixel-level reasoning. The effectiveness of our approach has been verified on 10 benchmarks across a diverse set of tasks, including pixel-level referring/segmentation and object-centric understanding in images/videos. A novel PixelQA task that jointly requires referring, segmentation, and question answering is also designed to verify the flexibility of our method.

Poster
PlanarGS: High-Fidelity Indoor 3D Gaussian Splatting Guided by Vision-Language Planar Priors

Xirui Jin, Renbiao Jin, Boying Li, Danping Zou, Wenxian Yu

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Three-dimensional Gaussian Splatting (3DGS) has recently emerged as an efficient representation for novel-view synthesis, achieving impressive visual quality. However, in scenes dominated by large and low-texture regions, common in indoor environments, the photometric loss used to optimize 3DGS yields ambiguous geometry and fails to recover high-fidelity 3D surfaces. To overcome this limitation, we introduce PlanarGS, a 3DGS-based framework tailored for indoor scene reconstruction. Specifically, we design a pipeline for Language-Prompted Planar Priors (LP3) that employs a pretrained vision-language segmentation model and refines its region proposals via cross-view fusion and inspection with geometric priors. 3D Gaussians in our framework are optimized with two additional terms: a planar prior supervision term that enforces planar consistency, and a geometric prior supervision term that steers the Gaussians toward the depth and normal cues. We have conducted extensive experiments on standard indoor benchmarks. The results show that PlanarGS reconstructs accurate and detailed 3D surfaces, consistently outperforming state-of-the-art methods by a large margin. Project page: https://planargs.github.io

Poster
A unified framework for establishing the universal approximation of transformer-type architectures

Jingpu Cheng, Ting Lin, Zuowei Shen, Qianxiao Li

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We investigate the universal approximation property (UAP) of transformer-type architectures, providing a unified theoretical framework that extends prior results on residual networks to models incorporating attention mechanisms. Our work identifies token distinguishability as a fundamental requirement for UAP and introduces a general sufficient condition that applies to a broad class of architectures. Leveraging an analyticity assumption on the attention layer, we can significantly simplify the verification of this condition, providing a non-constructive approach in establishing UAP for such architectures. We demonstrate the applicability of our framework by proving UAP for transformers with various attention mechanisms, including kernel-based and sparse ones. The corollaries of our results either generalize prior works or establish UAP for architectures not previously covered. Furthermore, our framework offers a principled foundation for designing novel transformer architectures with inherent UAP guarantees, including those with specific functional symmetries. We propose examples to illustrate these insights.

Poster
FastVID: Dynamic Density Pruning for Fast Video Large Language Models

Leqi Shen, Guoqiang Gong, Tao He, Yifeng Zhang, Pengzhang Liu, Sicheng Zhao, Guiguang Ding

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Video Large Language Models have demonstrated strong video understanding capabilities, yet their practical deployment is hindered by substantial inference costs caused by redundant video tokens. Existing pruning techniques fail to effectively exploit the spatiotemporal redundancy present in video data. To bridge this gap, we perform a systematic analysis of video redundancy from two perspectives: temporal context and visual context. Leveraging these insights, we propose Dynamic Density Pruning for Fast Video LLMs termed FastVID. Specifically, FastVID dynamically partitions videos into temporally ordered segments to preserve temporal structure and applies a density-based token pruning strategy to maintain essential spatial and temporal information. Our method significantly reduces computational overhead while maintaining temporal and visual integrity. Extensive evaluations show that FastVID achieves state-of-the-art performance across various short- and long-video benchmarks on leading Video LLMs, including LLaVA-OneVision, LLaVA-Video, Qwen2-VL, and Qwen2.5-VL. Notably, on LLaVA-OneVision-7B, FastVID effectively prunes $\textbf{90.3\%}$ of video tokens, reduces FLOPs to $\textbf{8.3\%}$, and accelerates the prefilling stage by $\textbf{7.1}\times$, while maintaining $\textbf{98.0\%}$ of the original accuracy. The code is available at https://github.com/LunarShen/FastVID.

Poster
Understanding the Gain from Data Filtering in Multimodal Contrastive Learning

Divyansh Pareek, Sewoong Oh, Simon Shaolei Du

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The success of modern multimodal representation learning relies on internet-scale datasets. Due to the low quality of a large fraction of raw web data, data curation has become a critical step in the training pipeline. Filtering using a trained model (i.e., teacher-based filtering) has emerged as a successful solution, leveraging a pre-trained model to compute quality scores. To explain the empirical success of teacher-based filtering, we characterize the performance of filtered contrastive learning under the standard bimodal data generation model. Denoting $\eta\in(0,1]$ as the fraction of data with correctly matched modalities among $n$ paired samples, we utilize a linear contrastive learning setup to show a provable benefit of data filtering: $(i)$ the error without filtering is upper and lower bounded by $\frac{1}{\eta \sqrt{n}}$, and $(ii)$ the error with teacher-based filtering is upper bounded by $\frac{1}{\sqrt{\eta n}}$ in the large $\eta$ regime, and by $\frac{1}{\sqrt{n}}$ in the small $\eta$ regime.

Poster
Improve Temporal Reasoning in Multimodal Large Language Models via Video Contrastive Decoding

Daiqing Qi, Dongliang Guo, Hanzhang Yuan, Handong Zhao, Mengxuan Hu, Lehan Yang, Sheng Li

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A major distinction between video and image understanding is that the former requires reasoning over time. Existing Video Large Language Models (VLLMs) demonstrate promising performance in general video understanding, such as brief captioning or object recognition within individual frames. However, they often struggle with temporal reasoning such as understanding continuous actions or tracking object transformations over time—which typically demands the integration of multiple frames in a temporally coherent manner. We first explore and explain such failures in Video LLMs from the perspective of \textit{language and ``image'' priors.} While existing research has attempted to enhance the temporal understanding of VLLMs through various training strategies, the demand for expensive computational resources and training data often presents significant barriers. To this end, we further propose a simple yet novel idea for improving temporal reasoning in videos at no additional training cost. Specifically, to better capture the temporal structure across multiple frames—the key to effective temporal reasoning—we distort the temporal consistency in key frames \textit{during the decoding phase}. Such corruption induces time-insensitive wrong responses from the model, which are then contrastively avoided when generating the final correct output. In this way, the model is encouraged to perform more temporally coherent reasoning. Our method yields consistent improvements across both temporal-specific and general video understanding benchmarks, demonstrating its effectiveness and generalizability.

Poster
See&Trek: Training-Free Spatial Prompting for Multimodal Large Language Model

Pengteng Li, Pinhao Song, Wuyang Li, Huizai Yao, Weiyu Guo, Yijie Xu, Dugang Liu, Hui Xiong

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We introduce See&Trek, the first training-free prompting framework tailored to enhance the spatial understanding of Multimodal Large Language Models (MLLMs) under vision-only constraints. While prior efforts have incorporated modalities like depth or point clouds to improve spatial reasoning, purely visual-spatial understanding remains underexplored. See&Trek addresses this gap by focusing on two core principles: increasing visual diversity and motion reconstruction. For visual diversity, we conduct Maximum Semantic Richness Sampling, which employs an off-the-shell perception model to extract semantically rich keyframes that capture scene structure. For motion reconstruction, we simulate visual trajectories and encode relative spatial positions into keyframes to preserve both spatial relations and temporal coherence. Our method is training&GPU-free, requiring only a single forward pass, and can be seamlessly integrated into existing MLLMs. Extensive experiments on the VSI-Bench and STI-Bench show that See&Trek consistently boosts various MLLMs performance across diverse spatial reasoning tasks with the most +3.5% improvement, offering a promising path toward stronger spatial intelligence.

Poster
CovMatch: Cross-Covariance Guided Multimodal Dataset Distillation with Trainable Text Encoder

Yongmin Lee, Hye Won Chung

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Multimodal dataset distillation aims to synthesize a small set of image-text pairs that enables efficient training of large-scale vision-language models. While dataset distillation has shown promise in unimodal tasks, extending it to multimodal contrastive learning presents key challenges: learning cross-modal alignment and managing the high computational cost of large encoders. Prior approaches address scalability by freezing the text encoder and update only the image encoder and text projection layer. However, we find this severely limits semantic alignment and becomes a bottleneck for performance scaling. We propose CovMatch, a scalable dataset distillation framework that aligns the cross-covariance of real and synthetic features while regularizing feature distributions within each modality. Unlike prior approaches, CovMatch enables joint optimization of both encoders, leading to stronger cross-modal alignment and improved performance. Evaluated on Flickr30K and COCO, CovMatch outperforms state-of-the-art multimodal distillation methods and achieves up to 6.8\% absolute gains in retrieval accuracy using only 500 synthetic pairs.

Poster
Improving Formal Reasoning of Transformer with State Stack

Kechi Zhang, Ge Li, Jia Li, Huangzhao Zhang, Yihong Dong, Jingjing Xu, Zhi Jin

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The Transformer architecture has emerged as a landmark advancement within the broad field of artificial intelligence, effectively catalyzing the advent of large language models (LLMs). However, despite its remarkable capabilities and the substantial progress it has facilitated, the Transformer architecture still has some limitations. One such intrinsic limitation is its inability to effectively recognize regular expressions or deterministic context-free grammars. Drawing inspiration from pushdown automata, which efficiently resolve deterministic context-free grammars using stacks, we equip layers with a differentiable stack and propose StackTrans to address the aforementioned issue within LLMs. Unlike previous approaches that modify the attention computation, StackTrans explicitly incorporates hidden state stacks between Transformer layers. This design maintains compatibility with existing frameworks like flash-attention. Specifically, our design features stack operations -- such as pushing and popping hidden states -- that are differentiable and can be learned in an end-to-end manner. Our comprehensive evaluation spans benchmarks for both Chomsky hierarchy and large-scale natural languages. Across these diverse tasks, StackTrans consistently outperforms standard Transformer models and other baselines. We have successfully scaled StackTrans up from 360M to 7B parameters. In particular, our from-scratch pretrained model StackTrans-360M outperforms several larger open-source LLMs with 2–3x more parameters, showcasing its superior efficiency and reasoning capability.

Poster
Multimodal Disease Progression Modeling via Spatiotemporal Disentanglement and Multiscale Alignment

Chen Liu, Wenfang Yao, Kejing Yin, William K. Cheung, Jing Qin

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Longitudinal multimodal data, including electronic health records (EHR) and sequential chest X-rays (CXRs), is critical for modeling disease progression, yet remains underutilized due to two key challenges: (1) redundancy in consecutive CXR sequences, where static anatomical regions dominate over clinically-meaningful dynamics, and (2) temporal misalignment between sparse, irregular imaging and continuous EHR data. We introduce $\texttt{DiPro}$, a novel framework that addresses these challenges through region-aware disentanglement and multi-timescale alignment. First, we disentangle static (anatomy) and dynamic (pathology progression) features in sequential CXRs, prioritizing disease-relevant changes. Second, we hierarchically align these static and dynamic CXR features with asynchronous EHR data via local (pairwise interval-level) and global (full-sequence) synchronization to model coherent progression pathways. Extensive experiments on the MIMIC dataset demonstrate that $\texttt{DiPro}$ could effectively extract temporal clinical dynamics and achieve state-of-the-art performance on both disease progression identification and general ICU prediction tasks.

Spotlight
BMMR: A Large-Scale Bilingual Multimodal Multi-Discipline Reasoning Dataset

Zhiheng Xi, Guanyu Li, YuTao Fan, Honglin Guo, Yufang Liu, Xiaoran Fan, Jiaqi Liu, dingjinchao, Wangmeng Zuo, Zhenfei Yin, Lei Bai, Tao Ji, Tao Gui, Qi Zhang, Xuanjing Huang

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In this paper, we introduce BMMR, a large-scale bilingual, multimodal, multi-disciplinary reasoning dataset for the community to develop and evaluate large multimodal models (LMMs). BMMR comprises 100k university-level questions drawn from 300 UNESCO-defined subjects, spanning diverse formats—multiple-choice, fill-in-the-blank, and open-ended QA—and sourced from both print and digital media such as books, exams, and quizzes. All data are curated and filtered via a human-in-the-loop, automated, and scalable framework, and each instance is paired with a high-quality reasoning path. The dataset is organized into two parts: BMMR-Eval that comprises 20k high-quality instances to comprehensively assess LMMs’ knowledge and reasoning across multiple disciplines in both Chinese and English; and BMMR-Train that contains 80k instances to support further research and development, extending the current focus on mathematical reasoning to diverse disciplines and domains. In addition, we propose the process-based multi-discipline BMMR-Verifier for accurate and fine-grained evaluation of LMMs’ reasoning. Extensive experiments reveal that (i) even SOTA models leave substantial headroom on BMMR-Eval; (ii) reasoning models exhibit discipline bias and outperform LMMs only on specific subjects; (iii) open-source models still trail their proprietary counterparts; and (iv) fine-tuning on BMMR-Train narrows this gap. Additionally, we conduct reasoning-chain analyses using BMMR-Verifier and other in-depth studies, uncovering the challenges LMMs currently face in multidisciplinary reasoning. We will release the data and models, and we believe our work can offers valuable insights and contributions to the community.

Poster
Eyes Wide Open: Ego Proactive Video-LLM for Streaming Video

Yulin Zhang, Cheng Shi, Yang Wang, Sibei Yang

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Envision an AI capable of functioning in human-like settings, moving beyond mere observation to actively understand, anticipate, and proactively respond to unfolding events. Towards this vision, we focus on the innovative task where, given ego-streaming video input, an assistant proactively answers diverse, evolving questions at the opportune moment, while maintaining synchronized perception and reasoning. This task embodies three key properties: (1) Proactive Coherence, (2) Just-in-Time Responsiveness, and (3) Synchronized Efficiency. To evaluate and address these properties, we first introduce ESTP-Bench (Ego Streaming Proactive Benchmark) alongside the ESTP-F1 metric—a novel framework designed for their rigorous assessment. Secondly, we propose a comprehensive technical pipeline to enable models to tackle this challenging task. This pipeline comprises: (1) a data engine, (2) a multi-stage training strategy, and (3) a proactive dynamic compression technique. Our proposed model effectively addresses these critical properties while achieving state-of-the-art (SOTA) performance on the standard COIN benchmark.

Poster
Rendering-Aware Reinforcement Learning for Vector Graphics Generation

Juan A. Rodriguez, Haotian Zhang, Abhay Puri, Rishav Pramanik, Aarash Feizi, Pascal Wichmann, Arnab Kumar Mondal, Mohammad Reza Samsami, Rabiul Awal, Perouz Taslakian, Spandana Gella, Sai Rajeswar, David Vazquez, Christopher Pal, Marco Pedersoli

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Scalable Vector Graphics (SVG) offer a powerful format for representing visual designs as interpretable code. Recent advances in vision-language models (VLMs) have enabled high-quality SVG generation by framing the problem as a code generation task and leveraging large-scale pretraining. VLMs are particularly suitable for this task as they capture both global semantics and fine-grained visual patterns, while transferring knowledge across vision, natural language, and code domains. However, existing VLM approaches often struggle to produce faithful and efficient SVGs because they never observe the rendered images during training. Although differentiable rendering for autoregressive SVG code generation remains unavailable, rendered outputs can still be compared to original inputs, enabling evaluative feedback suitable for reinforcement learning (RL). We introduce Reinforcement Learning from Rendering Feedback, an RL method that enhances SVG generation in autoregressive VLMs by leveraging feedback from rendered SVG outputs. Given an input image, the model generates SVG roll-outs that are rendered and compared to the original image to compute a reward. This visual fidelity feedback guides the model toward producing more accurate, efficient, and semantically coherent SVGs. \method significantly outperforms supervised fine-tuning, addressing common failure modes and enabling precise, high-quality SVG generation with strong structural understanding and generalization.

Poster
DOTA: Distributional Test-time Adaptation of Vision-Language Models

Zongbo Han, Jialong Yang, Guangyu Wang, Junfan Li, Qianli Xu, Mike Zheng Shou, Changqing Zhang

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Vision-language foundation models (VLMs), such as CLIP, exhibit remarkable performance across a wide range of tasks. However, deploying these models can be unreliable when significant distribution gaps exist between training and test data, while fine-tuning for diverse scenarios is often costly. Cache-based test-time adapters offer an efficient alternative by storing representative test samples to guide subsequent classifications. Yet, these methods typically employ naive cache management with limited capacity, leading to severe catastrophic forgetting when samples are inevitably dropped during updates. In this paper, we propose DOTA (DistributiOnal Test-time Adaptation), a simple yet effective method addressing this limitation. Crucially, instead of merely memorizing individual test samples, DOTA continuously estimates the underlying distribution of the test data stream. Test-time posterior probabilities are then computed using these dynamically estimated distributions via Bayes' theorem for adaptation. This distribution-centric approach enables the model to continually learn and adapt to the deployment environment. Extensive experiments validate that DOTA significantly mitigates forgetting and achieves state-of-the-art performance compared to existing methods.

Poster
Beyond Single-Task: Robust Multi-Task Length Generalization for LLMs

Yi Hu, Shijia Kang, Haotong Yang, Haotian Xu, Muhan Zhang

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Length generalization—the ability to solve problems longer than those seen during training—remains a critical challenge for large language models (LLMs). Previous work modifies positional encodings (PEs) and data formats to improve length generalization on specific symbolic tasks such as addition and sorting. However, these approaches are fundamentally limited to special tasks, often degrading general language performance. Furthermore, they are typically evaluated on small transformers trained from scratch on single tasks and can cause performance drop when applied during post-training stage of practical LLMs with general capabilities. Hu et al., (2024) proposed Rule-Following Fine-Tuning (RFFT) to improve length generalization in the post-training stage of LLMs. Despite its compatibility with practical models and strong performance, RFFT is proposed for single tasks too, requiring re-training for each individual task with extensive examples. In this paper, we study length generalization in multi-task settings and propose *Meta Rule-Following Fine-Tuning (Meta-RFFT)*, the first framework enabling robust *cross-task* length generalization. As our first contribution, we construct a large length generalization dataset containing **86 tasks** spanning code execution, number processing, symbolic and logical reasoning tasks, beyond the common addition or multiplication tasks. Secondly, we show that cross-task length generalization is possible with Meta-RFFT—after training on a large number of tasks and instances, the models achieve remarkable length generalization ability on *unseen* tasks with *minimal fine-tuning or one-shot prompting*. For example, after fine-tuning on 1 to 5 digit addition, our 32B model **achieves 95% accuracy on 30 digit addition**, significantly outperforming the state-of-the-art reasoning models (DeepSeek-R1-671B: 72%; QwQ-32B: 32%), despite never seeing this task during RF-pretraining.

Poster
Unsupervised Trajectory Optimization for 3D Registration in Serial Section Electron Microscopy using Neural ODEs

Zhenbang Zhang, Jingtong Feng, Hongjia Li, Haythem El-Messiry, zhiqiang xu, Renmin Han

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Series Section Electron Microscopy (ssEM) has emerged as a pivotal technology for deciphering nanoscale biological architectures. Three-dimensional (3D) registration is a critical step in ssEM, tasked with rectifying axial misalignments and nonlinear distortions introduced during serial sectioning. The core scientific challenge lies in achieving distortion mitigation without erasing the natural morphological deformations of biological tissues, thereby enabling faithful reconstruction of 3D ultrastructural organization. In this study, we present a paradigm-shifting optimization framework that rethinks 3D registration through the lens of manifold trajectory optimization. We propose the first continuous trajectory dynamics formulation for 3D registration and introduce a novel optimization strategy. Specifically, we introduce a dual optimization objective that inherently balances global trajectory smoothness with local structural preservation, while developing a solver that combines Gauss-Seidel iteration with Neural ODEs to systematically integrate biophysical priors with data-driven deformation compensation. A key strength of our method is its fully unsupervised training, which avoids reliance on ground truth and suits ssEM scenarios where annotations are difficult to obtain. Extensive experiments on multiple datasets spanning diverse tissue types demonstrate our method's superior performance in structural restoration accuracy and cross-tissue robustness.

Poster