指代表达

Referring Image Segmentation (RIS) aims to segment the target object in an image given a natural language expression. While recent methods leverage pre-trained vision backbones and more training corpus to achieve impressive results, they predominantly focus on simple expressions—short, clear noun phrases like “red car” or “left girl”. This simplification often reduces RIS to a key word/concept matching problem, limiting the model’s ability to handle referential ambiguity in expressions. In this work, we identify two challenging real-world scenarios: object-distracting expressions, which involve multiple entities with contextual cues, and category-implicit expressions, where the object class is not explicitly stated. To address the challenges, we propose a novel framework, SaFiRe, which mimics the human two-phase cognitive process—first forming a global understanding, then refining it through detail-oriented inspection. This is naturally supported by Mamba’s scan-then-update property, which aligns with our phased design and enables efficient multi-cycle refinement with linear complexity. We further introduce aRefCOCO, a new benchmark designed to evaluate RIS models under ambiguous referring expressions. Extensive experiments on both standard and proposed datasets demonstrate the superiority of SaFiRe over state-of-the-art baselines.

Gene expression estimation from pathology images has the potential to reduce the RNA sequencing cost. Point-wise loss functions have been widely used to minimize the discrepancy between predicted and absolute gene expression values. However, due to the complexity of the sequencing techniques and intrinsic variability across cells, the observed gene expression contains stochastic noise and batch effects, and estimating the absolute expression values accurately remains a significant challenge. To mitigate this, we propose a novel objective of learning relative expression patterns rather than absolute levels. We assume that the relative expression levels of genes exhibit consistent patterns across independent experiments, even when absolute expression values are affected by batch effects and stochastic noise in tissue samples. Based on the assumption, we model the relation and propose a novel loss function called STRank that is robust to noise and batch effects. Experiments using synthetic datasets and real datasets demonstrate the effectiveness of the proposed method. The code is available at https://github.com/naivete5656/STRank.

In single-cell perturbation prediction, a central task is to forecast the effects of perturbing a gene unseen in the training data. The efficacy of such predictions depends on two factors: (1) the similarity of the target gene to those covered in the training data, which informs model (epistemic) uncertainty, and (2) the quality of the corresponding training data, which reflects data (aleatoric) uncertainty. Both factors are critical for determining the reliability of a prediction, particularly as gene perturbation is an inherently stochastic biochemical process. In this paper, we propose PRESCRIBE (PREdicting Single-Cell Response wIth Bayesian Estimation), a multivariate deep evidential regression framework designed to measure both sources of uncertainty jointly. Our analysis demonstrates that PRESCRIBE effectively estimates a confidence score for each prediction, which strongly correlates with its empirical accuracy. This capability enables the filtering of untrustworthy results, and in our experiments, it achieves steady accuracy improvements of over 3% compared to comparable baselines.

We present an open-vocabulary and zero-shot method for arbitrary referring expression segmentation (RES), targeting input expressions that are more general than what prior works were designed to handle. Specifically, our inputs encompass both object- and part-level labels as well as implicit references pointing to properties or qualities of object/part function, design, style, material, etc. Our model, coined RESAnything, leverages Chain-of-Thoughts (CoT) reasoning, where the key idea is attribute prompting. We generate detailed descriptions of object/part attributes including shape, color, and location for potential segment proposals through systematic prompting of a large language model (LLM), where the proposals are produced by a foundational image segmentation model. Our approach encourages deep reasoning about object or part attributes related to function, style, design, etc., enabling the system to handle implicit queries without any part annotations for training or fine-tuning. As the first zero-shot and LLM-based RES method, RESAnything achieves clearly superior performance among zero-shot methods on traditional RES benchmarks and significantly outperforms existing methods on challenging scenarios involving implicit queries and complex part-level relations. Finally, we contribute a new benchmark dataset to offer ~3K carefully curated RES instances to assess part-level, arbitrary RES solutions.

Recent advances in Large Multi-modal Models (LMMs) have demonstrated their remarkable success as general-purpose multi-modal assistants, with particular focuses on holistic image- and video-language understanding. Conversely, less attention has been given to scaling fine-grained pixel-level understanding capabilities, where the models are expected to realize pixel-level alignment between visual signals and language semantics. Some previous studies have applied LMMs to related tasks such as region-level captioning and referring expression segmentation. However, these models are limited to performing either referring or segmentation tasks independently and fail to integrate these fine-grained perception capabilities into visual reasoning. To bridge this gap, we propose UniPixel, a large multi-modal model capable of flexibly comprehending visual prompt inputs and generating mask-grounded responses. Our model distinguishes itself by seamlessly integrating pixel-level perception with general visual understanding capabilities. Specifically, UniPixel processes visual prompts and generates relevant masks on demand, and performs subsequent reasoning conditioning on these intermediate pointers during inference, thereby enabling fine-grained pixel-level reasoning. The effectiveness of our approach has been verified on 10 benchmarks across a diverse set of tasks, including pixel-level referring/segmentation and object-centric understanding in images/videos. A novel PixelQA task that jointly requires referring, segmentation, and question answering is also designed to verify the flexibility of our method.