医疗政策建模

Electron-multiplying charge-coupled device (EMCCD) has been instrumental in sensitive observations under low-light situations including astronomy, material science, and biology. Despite its ingenious designs to enhance target signals overcoming read-out circuit noises, produced images are not completely noise free, which could still cast a cloud on desired experiment outcomes, especially in fluorescence microscopy. Existing studies on EMCCD's noise model have been focusing on statistical characteristics in theory, yet unable to incorporate latest advancements in the field of computational photography, where physics-based noise models are utilized to guide deep learning processes, creating adaptive denoising algorithms for ordinary image sensors. Still, those models are not directly applicable to EMCCD. In this paper, we intend to pioneer EMCCD denoising by introducing a systematic study on physics-based noise model calibration procedures for an EMCCD camera, accurately estimating statistical features of observable noise components in experiments, which are then utilized to generate substantial amount of authentic training samples for one of the most recent neural networks. A first real-world test image dataset for EMCCD is captured, containing both images of ordinary daily scenes and those of microscopic contents. Benchmarking upon the testset and authentic microscopic images, we demonstrate distinct advantages of our model against previous methods for EMCCD and physics-based noise modeling, forging a promising new path for EMCCD denoising.

In this study, we propose a novel rule-based interpretable choice model, {\bf Logic-Logit}, designed to effectively learn and explain human choices. Choice models have been widely applied across various domains—such as commercial demand forecasting, recommendation systems, and consumer behavior analysis—typically categorized as parametric, nonparametric, or deep network-based. While recent innovations have favored neural network approaches for their computational power, these flexible models often involve large parameter sets and lack interpretability, limiting their effectiveness in contexts where transparency is essential. Previous empirical evidence shows that individuals usually use {\it heuristic decision rules} to form their consideration sets, from which they then choose. These rules are often represented as {\it disjunctions of conjunctions} (i.e., OR-of-ANDs). These rules-driven, {\it consider-then-choose} decision processes enable people to quickly screen numerous alternatives while reducing cognitive and search costs. Motivated by this insight, our approach leverages logic rules to elucidate human choices, providing a fresh perspective on preference modeling. We introduce a unique combination of column generation techniques and the Frank-Wolfe algorithm to facilitate efficient rule extraction for preference modeling—a process recognized as NP-hard. Our empirical evaluation, conducted on both synthetic datasets and real-world data from commercial and healthcare domains, demonstrates that Logic-Logit significantly outperforms baseline models in terms of interpretability and accuracy.

Discrete diffusion models with absorbing processes have shown promise in language modeling. The key quantities to be estimated are the ratios between the marginal probabilities of two transitive states at all timesteps, called the concrete score. In this paper, we reveal that the concrete score in absorbing diffusion can be expressed as conditional probabilities of clean data, multiplied by a time-dependent scalar in an analytic form. Motivated by this finding, we propose reparameterized absorbing discrete diffusion (RADD), a dedicated diffusion model without time-condition that characterizes the time-independent conditional probabilities. Besides its simplicity, RADD can reduce the number of function evaluations (NFEs) by caching the output of the time-independent network when the noisy sample remains unchanged in a sampling interval, which enables sampling acceleration. Built upon the new perspective of conditional distributions, we further unify absorbing discrete diffusion and any-order autoregressive models (AO-ARMs), showing that the upper bound on the negative log-likelihood for the diffusion model can be interpreted as an expected negative log-likelihood for AO-ARMs. Further, our RADD models achieve SOTA performance among diffusion models on 5 zero-shot language modeling benchmarks (measured by perplexity) at the GPT-2 scale. Our code is available at \url{https://github.com/ML-GSAI/RADD}.

We study the discriminative probabilistic modeling on a continuous domain for the data prediction task of (multimodal) self-supervised representation learning. To address the challenge of computing the integral in the partition function for each anchor data, we leverage the multiple importance sampling (MIS) technique for robust Monte Carlo integration, which can recover InfoNCE-based contrastive loss as a special case. Within this probabilistic modeling framework, we conduct generalization error analysis to reveal the limitation of current InfoNCE-based contrastive loss for self-supervised representation learning and derive insights for developing better approaches by reducing the error of Monte Carlo integration. To this end, we propose a novel non-parametric method for approximating the sum of conditional probability densities required by MIS through convex optimization, yielding a new contrastive objective for self-supervised representation learning. Moreover, we design an efficient algorithm for solving the proposed objective. We empirically compare our algorithm to representative baselines on the contrastive image-language pretraining task. Experimental results on the CC3M and CC12M datasets demonstrate the superior overall performance of our algorithm. Our code is available at https://github.com/bokun-wang/NUCLR.

In the unsupervised pre-training for reinforcement learning, the agent aims to learn a prior policy for downstream tasks without relying on task-specific reward functions. We focus on state entropy maximization (SEM), where the goal is to learn a policy that maximizes the entropy of the state's stationary distribution. In this paper, we introduce SEMDICE, a principled off-policy algorithm that computes an SEM policy from an arbitrary off-policy dataset, which optimizes the policy directly within the space of stationary distributions. SEMDICE computes a single, stationary Markov state-entropy-maximizing policy from an arbitrary off-policy dataset. Experimental results demonstrate that SEMDICE outperforms baseline algorithms in maximizing state entropy while achieving the best adaptation efficiency for downstream tasks among SEM-based unsupervised RL pre-training methods.

Learning policy from offline datasets through offline reinforcement learning (RL) holds promise for scaling data-driven decision-making while avoiding unsafe and costly online interactions. However, real-world data collected from sensors or humans often contains noise and errors, posing a significant challenge for existing offline RL methods, particularly when the real-world data is limited. Our study reveals that prior research focusing on adapting predominant offline RL methods based on temporal difference learning still falls short under data corruption when the dataset is limited. In contrast, we discover that vanilla sequence modeling methods, such as Decision Transformer, exhibit robustness against data corruption, even without specialized modifications. To unlock the full potential of sequence modeling, we propose **R**obust **D**ecision **T**ransformer (**RDT**) by incorporating three simple yet effective robust techniques: embedding dropout to improve the model's robustness against erroneous inputs, Gaussian weighted learning to mitigate the effects of corrupted labels, and iterative data correction to eliminate corrupted data from the source. Extensive experiments on MuJoCo, Kitchen, and Adroit tasks demonstrate RDT's superior performance under various data corruption scenarios compared to prior methods. Furthermore, RDT exhibits remarkable robustness in a more challenging setting that combines training-time data corruption with test-time observation perturbations. These results highlight the potential of sequence modeling for learning from noisy or corrupted offline datasets, thereby promoting the reliable application of offline RL in real-world scenarios. Our code is available at https://github.com/jiawei415/RobustDecisionTransformer。

Policy Mirror Descent (PMD) is a popular framework in reinforcement learning, serving as a unifying perspective that encompasses numerous algorithms. These algorithms are derived through the selection of a mirror map and enjoy finite-time convergence guarantees. Despite its popularity, the exploration of PMD's full potential is limited, with the majority of research focusing on a particular mirror map---namely, the negative entropy---which gives rise to the renowned Natural Policy Gradient (NPG) method. It remains uncertain from existing theoretical studies whether the choice of mirror map significantly influences PMD's efficacy. In our work, we conduct empirical investigations to show that the conventional mirror map choice (NPG) often yields less-than-optimal outcomes across several standard benchmark environments. Using evolutionary strategies, we identify more efficient mirror maps that enhance the performance of PMD. We first focus on a tabular environment, i.e.\ Grid-World, where we relate existing theoretical bounds with the performance of PMD for a few standard mirror maps and the learned one. We then show that it is possible to learn a mirror map that outperforms the negative entropy in more complex environments, such as the MinAtar suite. Additionally, we demonstrate that the learned mirror maps generalize effectively to different tasks by testing each map across various other environments.

Off-policy learning (OPL) in contextual bandits aims to learn a decision-making policy that maximizes the target rewards by using only historical interaction data collected under previously developed policies. Unfortunately, when rewards are only partially observed, the effectiveness of OPL degrades severely. Well-known examples of such partial rewards include explicit ratings in content recommendations, conversion signals on e-commerce platforms that are partial due to delay, and the issue of censoring in medical problems. One possible solution to deal with such partial rewards is to use secondary rewards, such as dwelling time, clicks, and medical indicators, which are more densely observed. However, relying solely on such secondary rewards can also lead to poor policy learning since they may not align with the target reward. Thus, this work studies a new and general problem of OPL where the goal is to learn a policy that maximizes the expected target reward by leveraging densely observed secondary rewards as supplemental data. We then propose a new method called Hybrid Policy Optimization for Partially-Observed Reward (HyPeR), which effectively uses the secondary rewards in addition to the partially observed target reward to achieve effective OPL despite the challenging scenario. We also discuss a case where we aim to optimize not only the expected target reward but also the expected secondary rewards to some extent; counter-intuitively, we will show that leveraging the two objectives is in fact advantageous also for the optimization of only the target reward. Along with statistical analysis of our proposed methods, empirical evaluations on both synthetic and real-world data show that HyPeR outperforms existing methods in various scenarios.

Pretraining data of large language models composes multiple domains (e.g., web texts, academic papers, codes), whose mixture proportions crucially impact the competence of outcome models. While existing endeavors rely on heuristics or qualitative strategies to tune the proportions, we discover the quantitative predictability of model performance regarding the mixture proportions in function forms, which we refer to as the data mixing laws. Fitting such functions on sample mixtures unveils model performance on unseen mixtures before actual runs, thus guiding the selection of an ideal data mixture. Furthermore, we propose nested use of the scaling laws of training steps, model sizes, and our data mixing laws to predict the performance of large models trained on massive data under various mixtures with only small-scale training. Experimental results verify that our method effectively optimizes the training mixture of a 1B model trained for 100B tokens in RedPajama, reaching a performance comparable to the one trained for 48% more steps on the default mixture. Extending the application of data mixing laws to continual training accurately predicts the critical mixture proportion that avoids catastrophic forgetting and outlooks the potential for dynamic data schedules.

Following the impressive capabilities of in-context learning with large transformers, In-Context Imitation Learning (ICIL) is a promising opportunity for robotics. We introduce Instant Policy, which learns new tasks instantly from just one or two demonstrations, achieving ICIL through two key components. First, we introduce inductive biases through a graph representation and model ICIL as a graph generation problem using a learned diffusion process, enabling structured reasoning over demonstrations, observations, and actions. Second, we show that such a model can be trained using pseudo-demonstrations – arbitrary trajectories generated in simulation – as a virtually infinite pool of training data. Our experiments, in both simulation and reality, show that Instant Policy enables rapid learning of various everyday robot tasks. We also show how it can serve as a foundation for cross-embodiment and zero-shot transfer to language-defined tasks.

Long-range sequence processing poses a significant challenge for Transformers due to their quadratic complexity in input length. A promising alternative is Mamba, which demonstrates high performance and achieves Transformer-level capabilities while requiring substantially fewer computational resources. In this paper we explore the length-generalization capabilities of Mamba, which we find to be relatively limited. Through a series of visualizations and analyses we identify that the limitations arise from a restricted effective receptive field, dictated by the sequence length used during training. To address this constraint, we introduce DeciMamba, a context-extension method specifically designed for Mamba. This mechanism, built on top of a hidden filtering mechanism embedded within the S6 layer, enables the trained model to extrapolate well even without additional training. Empirical experiments over real-world long-range NLP tasks show that DeciMamba can extrapolate to context lengths that are significantly longer than the ones seen during training, while enjoying faster inference. We will release our code and models.

Policies developed through Reinforcement Learning (RL) and Imitation Learning (IL) have shown great potential in continuous control tasks, but real-world applications often require adapting trained policies to unforeseen requirements. While fine-tuning can address such needs, it typically requires additional data and access to the original training metrics and parameters. In contrast, an online planning algorithm, if capable of meeting the additional requirements, can eliminate the necessity for extensive training phases and customize the policy without knowledge of the original training scheme or task. In this work, we propose a generic online planning algorithm for customizing continuous-control policies at the execution time, which we call Residual-MPPI. It can customize a given prior policy on new performance metrics in few-shot and even zero-shot online settings, given access to the prior action distribution alone. Through our experiments, we demonstrate that the proposed Residual-MPPI algorithm can accomplish the few-shot/zero-shot online policy customization task effectively, including customizing the champion-level racing agent, Gran Turismo Sophy (GT Sophy) 1.0, in the challenging car racing scenario, Gran Turismo Sport (GTS) environment. Code for MuJoCo experiments is included in the supplementary and will be open-sourced upon acceptance. Demo videos are available on our website: https://sites.google.com/view/residual-mppi.

Reinforcement learning algorithms typically necessitate extensive exploration of the state space to find optimal policies. However, in safety-critical applications, the risks associated with such exploration can lead to catastrophic consequences. Existing safe exploration methods attempt to mitigate this by imposing constraints, which often result in overly conservative behaviours and inefficient learning. Heavy penalties for early constraint violations can trap agents in local optima, deterring exploration of risky yet high-reward regions of the state space. To address this, we introduce a method that explicitly learns state-conditioned safety representations. By augmenting the state features with these safety representations, our approach naturally encourages safer exploration without being excessively cautious, resulting in more efficient and safer policy learning in safety-critical scenarios. Empirical evaluations across diverse environments show that our method significantly improves task performance while reducing constraint violations during training, underscoring its effectiveness in balancing exploration with safety.

We consider the problem of imitation learning under misspecification: settings where the learner is fundamentally unable to replicate expert behavior everywhere. This is often true in practice due to differences in observation space and action space expressiveness (e.g. perceptual or morphological differences between robots and humans). Given the learner must make some mistakes in the misspecified setting, interaction with the environment is fundamentally required to figure out which mistakes are particularly costly and lead to compounding errors. However, given the computational cost and safety concerns inherent in interaction, we'd like to perform as little of it as possible while ensuring we've learned a strong policy. Accordingly, prior work has proposed a flavor of efficient inverse reinforcement learning algorithms that merely perform a computationally efficient local search procedure with strong guarantees in the realizable setting. We first prove that under a novel structural condition we term reward-agnostic policy completeness, these sorts of local-search based IRL algorithms are able to avoid compounding errors. We then consider the question of where we should perform local search in the first place, given the learner may not be able to "walk on a tightrope" as well as the expert in the misspecified setting. We prove that in the misspecified setting, it is beneficial to broaden the set of states on which local search is performed to include those reachable by good policies the learner can actually play. We then experimentally explore a variety of sources of misspecification and how offline data can be used to effectively broaden where we perform local search from.

Recent advancements in robot learning have used imitation learning with large models and extensive demonstrations to develop effective policies. However, these models are often limited by the quantity quality, and diversity of demonstrations. This paper explores improving offline-trained imitation learning models through online interactions with the environment. We introduce Policy Decorator, which uses a model-agnostic residual policy to refine large imitation learning models during online interactions. By implementing controlled exploration strategies, Policy Decorator enables stable, sample-efficient online learning. Our evaluation spans eight tasks across two benchmarks—ManiSkill and Adroit—and involves two state-of-the-art imitation learning models (Behavior Transformer and Diffusion Policy). The results show Policy Decorator effectively improves the offline-trained policies and preserves the smooth motion of imitation learning models, avoiding the erratic behaviors of pure RL policies. See our [project page](https://policydecorator.github.io/) for videos.

Machine unlearning algorithms are increasingly important as legal concerns arise around the provenance of training data, but verifying the success of unlearning is often difficult. Provable guarantees for unlearning are often limited to supervised learning settings. In this paper, we provide the first theoretical guarantees for unlearning in the pre-training and fine-tuning paradigm by studying topic models, simple bag-of-words language models that can be adapted to solve downstream tasks like retrieval and classification. First, we design a provably effective unlearning algorithm for topic models that incurs a computational overhead independent of the size of the original dataset. Our analysis additionally quantifies the deletion capacity of the model -- i.e., the number of examples that can be unlearned without incurring a significant cost in model performance. Finally, we formally extend our analyses to account for adaptation to a given downstream task. In particular, we design an efficient algorithm to perform unlearning after fine-tuning the topic model via a linear head. Notably, we show that it is easier to unlearn pre-training data from models that have been fine-tuned to a particular task, and one can unlearn this data without modifying the base model.

Improving social welfare is a complex challenge requiring policymakers to optimize objectives across multiple time horizons. Evaluating the impact of such policies presents a fundamental challenge, as those that appear suboptimal in the short run may yield significant long-term benefits. We tackle this challenge by analyzing the long-term dynamics of two prominent policy frameworks: Rawlsian policies, which prioritize those with the greatest need, and utilitarian policies, which maximize immediate welfare gains. Conventional wisdom suggests these policies are at odds, as Rawlsian policies are assumed to come at the cost of reducing the average social welfare, which their utilitarian counterparts directly optimize. We challenge this assumption by analyzing these policies in a sequential decision-making framework where individuals' welfare levels stochastically decay over time, and policymakers can intervene to prevent this decay. Under reasonable assumptions, we prove that interventions following Rawlsian policies can outperform utilitarian policies in the long run, even when the latter dominate in the short run. We characterize the exact conditions under which Rawlsian policies can outperform utilitarian policies. We further illustrate our theoretical findings using simulations, which highlight the risks of evaluating policies based solely on their short-term effects. Our results underscore the necessity of considering long-term horizons in designing and evaluating welfare policies; the true efficacy of even well-established policies may only emerge over time.

Neurons in the brain are spatially organized such that neighbors on tissue often exhibit similar response profiles. In the human language system, experimental studies have observed clusters for syntactic and semantic categories, but the mechanisms underlying this functional organization remain unclear. Here, building on work from the vision literature, we develop TopoLM, a transformer language model with an explicit two-dimensional spatial representation of model units. By combining a next-token prediction objective with a spatial smoothness loss, representations in this model assemble into clusters that correspond to semantically interpretable groupings of text and closely match the functional organization in the brain's language system. TopoLM successfully predicts the emergence of a spatially organized cortical language system as well as the organization of functional clusters selective for fine-grained linguistic features empirically observed in human cortex. Our results suggest that the functional organization of the human language system is driven by a unified spatial objective, and provide a functionally and spatially aligned model of language processing in the brain.Neurons in the brain are spatially organized such that neighbors on tissue often exhibit similar response profiles. In the human language system, experimental studies have observed clusters for syntactic and semantic categories, but the mechanisms underlying this functional organization remain unclear. Here, building on work from the vision literature, we develop TopoLM, a transformer language model with an explicit two-dimensional spatial representation of model units. By combining a next-token prediction objective with a spatial smoothness loss, representations in this model assemble into clusters that correspond to semantically interpretable groupings of text and closely match the functional organization in the brain's language system. TopoLM successfully predicts the emergence of a spatially organized cortical language system as well as the organization of functional clusters selective for fine-grained linguistic features empirically observed in human cortex. Our results suggest that the functional organization of the human language system is driven by a unified spatial objective, and provide a functionally and spatially aligned model of language processing in the brain.

Off-Policy Evaluation and Learning (OPE/L) in contextual bandits is rapidly gaining popularity in real systems because new policies can be evaluated and learned securely using only historical logged data. However, existing methods in OPE/L cannot handle many challenging but prevalent scenarios such as few-shot data, deterministic logging policies, and new actions. In many applications, such as personalized medicine, content recommendations, education, and advertising, we need to evaluate and learn new policies in the presence of these challenges. Existing methods cannot evaluate and optimize effectively in these situations due to the notorious variance issue or limited exploration in the logged data. To enable OPE/L even under these unsolved challenges, we propose a new problem setup of Cross-Domain OPE/L, where we have access not only to the logged data from the target domain in which the new policy will be implemented but also to logged datasets collected from other domains. This novel formulation is widely applicable because we can often use historical data not only from the target hospital, country, device, or user segment but also from other hospitals, countries, devices, or segments. We develop a new estimator and policy gradient method to solve OPE/L by leveraging both target and source datasets, resulting in substantially enhanced OPE/L in the previously unsolved situations in our empirical evaluations.

We introduce an extensive new dataset of MIDI files, created by transcribing audio recordings of piano performances into their constituent notes. The data pipeline we use is multi-stage, employing a language model to autonomously crawl and score audio recordings from the internet based on their metadata, followed by a stage of pruning and segmentation using an audio classifier. The resulting dataset contains over one million distinct MIDI files, comprising roughly 100,000 hours of transcribed audio. We provide an in-depth analysis of our techniques, offering statistical insights, and investigate the content by extracting metadata tags, which we also provide. Dataset available at https://github.com/loubbrad/aria-midi.