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HyperST: Hierarchical Hyperbolic Learning for Spatial Transcriptomics Prediction
Chen Zhang, Yilu An, Ying Chen, Hao Li, Xitong Ling, Lihao Liu, Junjun He, Yuxiang Lin, Zihui Wang, Rongshan Yu
Spatial Transcriptomics (ST) merges the benefits of pathology images and gene expression, linking molecular profiles with tissue structure to analyze spot-level function comprehensively. Predicting gene expression from histology images is a cost-effective alternative to expensive ST technologies. However, existing methods mainly focus on spot-level image-to-gene matching but fail to leverage the full hierarchical structure of ST data, especially on the gene expression side, leading to incomplete image-gene alignment. Moreover, a challenge arises from the inherent information asymmetry: gene expression profiles contain more molecular details that may lack salient visual correlates in histological images, demanding a sophisticated representation learning approach to bridge this modality gap. We propose HyperST, a framework for ST prediction that learns multi-level image-gene representations by modeling the data's inherent hierarchy within hyperbolic space, a natural geometric setting for such structures. First, we design Multi-Level Representation Extractors to capture both spot-level and niche-level representations from each modality, providing context-aware information beyond individual spot-level image-gene pairs. Second, a Hierarchical Hyperbolic Alignment module is introduced to unify these representations, performing spatial alignment while hierarchically structuring image and gene embeddings. This alignment strategy enriches the image representations with molecular semantics, significantly improving cross-modal prediction. HyperST achieves state-of-the-art performance on four public datasets from different tissues, paving the way for scalable and accurate spatial transcriptomics prediction.
Generalizing Visual Geometry Priors to Sparse Gaussian Occupancy Prediction
Changqing Zhou, Yueru Luo, Changhao Chen
Accurate 3D scene understanding is essential for embodied intelligence, with occupancy prediction emerging as a key task for reasoning about both objects and free space. Existing approaches largely rely on depth priors (e.g., DepthAnything) but make only limited use of 3D cues, restricting performance and generalization. Recently, visual geometry models such as VGGT have shown strong capability in providing rich 3D priors, but similar to monocular depth foundation models, they still operate at the level of visible surfaces rather than volumetric interiors, motivating us to explore how to more effectively leverage these increasingly powerful geometry priors for 3D occupancy prediction. We present GPOcc, a framework that leverages generalizable visual geometry priors (GPs) for monocular occupancy prediction. Our method extends surface points inward along camera rays to generate volumetric samples, which are represented as Gaussian primitives for probabilistic occupancy inference. To handle streaming input, we further design a training-free incremental update strategy that fuses per-frame Gaussians into a unified global representation. Experiments on Occ-ScanNet and EmbodiedOcc-ScanNet demonstrate significant gains: GPOcc improves mIoU by +9.99 in the monocular setting and +11.79 in the streaming setting over prior state of the art. Under the same depth prior, it achieves +6.73 mIoU while running 2.65 times faster. These results highlight that GPOcc leverages geometry priors more effectively and efficiently. Code will be released at https://github.com/JuIvyy/GPOcc.
RAP: Fast Feedforward Rendering-Free Attribute-Guided Primitive Importance Score Prediction for Efficient 3D Gaussian Splatting Processing
Kaifa Yang, Qi Yang, Yiling Xu, Zhu Li
3D Gaussian Splatting (3DGS) has emerged as a leading technology for high-quality 3D scene reconstruction. However, the iterative refinement and densification process leads to the generation of a large number of primitives, each contributing to the reconstruction to a substantially different extent. Estimating primitive importance is thus crucial, both for removing redundancy during reconstruction and for enabling efficient compression and transmission.Existing methods typically rely on rendering-based analyses, where each primitive is evaluated through its contribution across multiple camera viewpoints. However, such methods are 1) sensitive to the number and selection of views; 2) rely on specialized differentiable rasterizers; and 3) have long calculation times that grow linearly with view count, making them difficult to integrate as plug-and-play modules, as well as resulting in limited scalability and generalization.To address these issues, we propose RAP -- a fast feedforward Rendering-free Attribute-guided method for efficient importance score Prediction in 3DGS. RAP infers primitive significance directly from intrinsic Gaussian attributes and local neighborhood statistics, avoiding any rendering-based or visibility-dependent computations. A compact MLP is trained to predict per-primitive importance scores using a combination of rendering loss, pruning-aware loss, and significance distribution regularization loss. After being trained on a small set of scenes, RAP generalizes effectively to unseen data and can be seamlessly integrated into reconstruction, compression, and transmission pipelines, providing a unified and efficient pruning solution.
OccAny: Generalized Unconstrained Urban 3D Occupancy
Anh-Quan Cao, Tuan-Hung Vu
Relying on in-domain annotations and precise sensor-rig priors, existing 3D occupancy prediction methods are limited in both scalability and out-of-domain generalization. While recent visual geometry foundation models exhibit strong generalization capabilities, they were mainly designed for general purposes and lack one or more key ingredients required for urban occupancy prediction, namely metric prediction, geometry completion in cluttered scenes and adaptation to urban scenarios. We address this gap and present OccAny, the first unconstrained urban 3D occupancy model capable of operating on out-of-domain uncalibrated scenes to predict and complete metric occupancy coupled with segmentation features. is versatile and can predict occupancy from sequential, monocular, or surround-view images. Our contributions are three-fold: (i) we propose the first generalized 3D occupancy framework with (ii)Segmentation Forcing that improves occupancy quality while enabling mask-level prediction, and (iii) a Novel View Rendering pipeline that infers novel-view geometry to enable test-time view augmentation for geometry completion. Extensive experiments demonstrate that OccAny outperforms all visual geometry baselines on 3D occupancy prediction task, while remaining competitive with in-domain self-supervised methods across three input settings on two established urban occupancy prediction datasets. Our code is available at https://github.com/valeoai/OccAny .
FlashPortrait: 6x Faster Infinite Portrait Animation with Adaptive Latent Prediction
Shuyuan Tu, Yueming Pan, Yinming Huang, Xintong Han, Zhen Xing, Qi Dai, Kai Qiu, Chong Luo, Zuxuan Wu
Current diffusion-based acceleration methods for long-portrait animation struggle to ensure identity (ID) consistency. This paper presents FlashPortrait, an end-to-end video diffusion transformer capable of synthesizing ID-preserving, infinite-length videos while achieving up to 6xacceleration in inference speed. In particular, FlashPortrait begins by computing the identity-agnostic facial expression features with an off-the-shelf extractor. It then introduces a Normalized Facial Expression Block to align facial features with diffusion latents by normalizing them with their respective means and variances, thereby improving identity stability in facial modeling. During inference, FlashPortrait adopts a dynamic sliding-window scheme with weighted blending in overlapping areas, ensuring smooth transitions and ID consistency in long animations. In each context window, based on the latent variation rate at particular timesteps and the derivative magnitude ratio among diffusion layers, FlashPortrait utilizes higher-order latent derivatives at the current timestep to directly predict latents at future timesteps, thereby skipping several denoising steps and achieving 6xspeed acceleration. Experiments on benchmarks show the effectiveness of FlashPortrait both qualitatively and quantitatively.
SparseWorld-TC: Trajectory-Conditioned Sparse Occupancy World Model
Jiayuan Du, Yiming Zhao, Zhenglong Guo, Yong Pan, Wenbo Hou, Zhihui Hao, Kun Zhan, Qijun Chen
This paper introduces a novel architecture for trajectory-conditioned forecasting of future 3D scene occupancy. In contrast to methods that rely on variational autoencoders (VAEs) to generate discrete occupancy tokens, which inherently limit representational capacity, our approach predicts multi-frame future occupancy in an end-to-end manner directly from raw image features. Inspired by the success of attention-based transformer architectures in foundational vision and language models such as GPT and VGGT, we employ a sparse occupancy representation that bypasses the intermediate bird's eye view (BEV) projection and its explicit geometric priors. This design allows the transformer to capture spatiotemporal dependencies more effectively. By avoiding both the finite-capacity constraint of discrete tokenization and the structural limitations of BEV representations, our method achieves state-of-the-art performance on the nuScenes benchmark for 1-3 second occupancy forecasting, outperforming existing approaches by a significant margin. Furthermore, it demonstrates robust scene dynamics understanding, consistently delivering high accuracy under arbitrary future trajectory conditioning.
Detect Anything via Next Point Prediction
Qing Jiang, Junan Huo, Xingyu Chen, Yuda Xiong, Zhaoyang Zeng, Yihao Chen, Tianhe Ren, Junzhi Yu, Lei Zhang
Object detection has long been dominated by traditional coordinate regression-based models, such as YOLO, DETR, and Grounding DINO. Although recent efforts have attempted to leverage MLLMs to tackle this task, they face challenges like low recall rate, duplicate predictions, coordinate misalignment, etc. In this work, we bridge this gap and propose Rex-Omni, a 3B-scale MLLM that achieves state-of-the-art object perception performance. On benchmarks like COCO and LVIS, Rex-Omni attains performance comparable to or exceeding regression-based models (e.g., DINO, Grounding DINO) in a zero-shot setting. This is enabled by three key designs: 1) Task Formulation: we use special tokens to represent quantized coordinates from 0 to 999, reducing the model's learning difficulty and improving token efficiency for coordinate prediction; 2) Data Engines: we construct multiple data engines to generate high-quality grounding, referring, and pointing data, providing semantically rich supervision for training; 3) Training Pipelines: we employ a two-stage training process, combining supervised fine-tuning on 22 million data with GRPO-based reinforcement post-training. This RL post-training leverages geometry-aware rewards to effectively bridge the discrete-to-continuous coordinate prediction gap, improve box accuracy, and mitigate undesirable behaviors like duplicate predictions that stem from the teacher-guided nature of the initial SFT stage. Beyond conventional detection, Rex-Omni's inherent language understanding enables versatile capabilities such as object referring, pointing, visual prompting, GUI grounding, spatial referring, OCR and key-pointing, all systematically evaluated on dedicated benchmarks. We believe that Rex-Omni paves the way for more versatile and language-aware visual perception systems.
ProOOD: Prototype-Guided Out-of-Distribution 3D Occupancy Prediction
Yuheng Zhang, Mengfei Duan, Kunyu Peng, Yuhang Wang, Di Wen, Danda Pani Paudel, Luc Van Gool, Kailun Yang
3D semantic occupancy prediction is central to autonomous driving, yet current methods are vulnerable to long-tailed class bias and out-of-distribution (OOD) inputs, often overconfidently assigning anomalies to rare classes. We present ProOOD, a lightweight, plug-and-play method that couples prototype-guided refinement with training-free OOD scoring. ProOOD comprises (i) prototype-guided semantic imputation that fills occluded regions with class-consistent features, (ii) prototype-guided tail mining that strengthens rare-class representations to curb OOD absorption, and (iii) EchoOOD, which fuses local logit coherence with local and global prototype matching to produce reliable voxel-level OOD scores. Extensive experiments on five datasets demonstrate that ProOOD achieves state-of-the-art performance on both in-distribution 3D occupancy prediction and OOD detection. On SemanticKITTI, it surpasses baselines by +3.57% mIoU overall and +24.80% tail-class mIoU; on VAA-KITTI, it improves AuPRC_r by +19.34 points, with consistent gains across benchmarks. These improvements yield more calibrated occupancy estimates and more reliable OOD detection in safety-critical urban driving. The source code will be made publicly available.
MVP: Multiple View Prediction Improves GUI Grounding
Yunzhu Zhang, Zeyu Pan, Zhengwen Zeng, Shuheng Shen, Changhua Meng, Linchao Zhu
GUI grounding, which translates natural language instructions into precise pixel coordinates, is essential for developing practical GUI agents. However, we observe that existing grounding models exhibit significant coordinate prediction instability--minor visual perturbations (e.g., cropping a few pixels) can drastically alter predictions, flipping results between correct and incorrect. This instability severely undermines model performance, especially for samples with high-resolution and small UI elements. To address this issue, we propose Multi-View Prediction (MVP), a training-free framework that enhances grounding performance through multi-view inference. Our key insight is that while single-view predictions may be unstable, aggregating predictions from multiple carefully cropped views can effectively distinguish correct coordinates from outliers. MVP comprises two components: (1) Attention-Guided View Proposal, which derives diverse views guided by instruction-to-image attention scores, and (2) Multi-Coordinates Clustering, which ensembles predictions by selecting the centroid of the densest spatial cluster. Extensive experiments demonstrate MVP's effectiveness across various models and benchmarks. Notably, on ScreenSpot-Pro, MVP boosts UI-TARS-1.5-7B to 56.1%, GTA1-7B to 61.7%, Qwen3VL-8B-Instruct to 65.3%, and Qwen3VL-32B-Instruct to 74.0%.
Deformable Gaussian Occupancy: Decoupling Rigid and Nonrigid Motion with Factorized Distillation
Yang Gao, Wuyang Li, Po-Chien Luan, Alexandre Alahi
Understanding dynamic 3D environments is essential for safe autonomous driving, particularly when reasoning about human-centric, nonrigid agents. However, existing weakly supervised occupancy prediction frameworks predominantly assume rigid-body motion and rely on simple frame-to-frame offsets, limiting their ability to capture fine-grained deformations and maintain temporal coherence. To address this issue, we propose DeGO, a deformable Gaussian occupancy framework that unifies decoupled Gaussian deformation with factorized 4D foundation-model distillation. DeGO disentangles rigid and nonrigid motion, enabling each Gaussian primitive to evolve through both deformation and offset-based updates. In parallel, a factorized 4D distillation strategy transfers cross-camera and cross-frame knowledge from the VGGT foundation model, producing foundation-aligned features that enhance temporal consistency. Experiments on the Occ3D-NuScenes benchmark demonstrate that our method achieves state-of-the-art performance under weak supervision, delivering 13.5% gains on human-centric instances and 10.9% overall improvements. These results highlight the effectiveness of deformation-aware and foundation-guided occupancy modeling for dynamic scene understanding.
Test-Time 3D Occupancy Prediction
Fengyi Zhang, Xiangyu Sun, Huitong Yang, Zheng Zhang, Zi Huang, Yadan Luo
Self-supervised 3D occupancy prediction offers a promising solution for understanding complex driving scenes without requiring costly 3D annotations. However, training dense occupancy decoders to capture fine-grained geometry and semantics can demand hundreds of GPU hours, and once trained, such models struggle to adapt to varying voxel resolutions or novel object categories without extensive retraining. To overcome these limitations, we propose a practical and flexible test-time occupancy prediction framework termed TT-Occ. Our method incrementally constructs, optimizes, and voxelizes time-aware 3D Gaussians from raw sensor streams by integrating vision foundation models (VFMs) at runtime. The flexible representation of 3D Gaussians enables voxelization at arbitrary user-specified resolutions, while the strong generalization capability of VFMs supports accurate perception and open-vocabulary recognition without requiring any network training or fine-tuning. To validate the generality and effectiveness of our framework, we present two variants: a LiDAR-based version and a vision-centric version, and conduct extensive experiments on the Occ3D-nuScenes and nuCraft benchmarks under varying voxel resolutions. Experimental results show that TT-Occ significantly outperforms existing computationally expensive pretrained self-supervised counterparts. Code is available at https://github.com/Xian-Bei/TT-Occ.
OneOcc: Semantic Occupancy Prediction for Legged Robots with a Single Panoramic Camera
Hao Shi, Ze Wang, Shangwei Guo, Mengfei Duan, Song Wang, Teng Chen, Kailun Yang, Lin Wang, kaiwei wang
Robust 3D semantic occupancy is essential for legged and humanoid robots, yet most Semantic Scene Completion (SSC) systems are built for wheeled platforms with forward-facing sensors. We present OneOcc, a vision-only panoramic SSC framework tailored to severe body jitter and 360deg continuity. OneOcc integrates four complementary modules: (i) Dual-Projection fusion (DP-ER), which jointly exploits the raw annular panorama and its equirectangular unfolding to preserve true 360deg continuity while enabling grid-aligned feature extraction and seam-aware context; (ii) Bi-Grid Voxelization (BGV), which reasons in Cartesian and polar/cylindrical voxel spaces to reduce discretization bias and better align with panoramic geometry, yielding sharper free/occupied boundaries; (iii) a lightweight decoder with Hierarchical AMoE-3D fusion that dynamically routes multi-scale 3D features to specialized experts, improving long-range context and occlusion handling; and (iv) a plug-and-play Gait Displacement Compensation (GDC) module that learns feature-level motion correction from gait, stabilizing representations without extra sensors. We also release two panoramic occupancy benchmarks: QuadOcc (real quadruped, first-person 360deg) and Human360Occ (H3O) (CARLA human-ego 360deg with RGB/Depth/semantic-occupancy and standardized within-/cross-city splits). OneOcc sets new SOTA: on QuadOcc it exceeds strong vision baselines and even popular LiDAR methods, and on H3O it improves within-city by +3.83 mIoU and cross-city by +8.08. The modules are lightweight, enabling deployable full-surround semantic perception for legged and humanoid robots.
Region-Wise Correspondence Prediction between Manga Line Art Images
Yingxuan Li, Jiafeng Mao, Qianru Qiu, Yusuke Matsui
Understanding region-wise correspondences between manga line art images is fundamental for high-level manga processing, supporting downstream tasks such as line art colorization and in-between frame generation. Unlike natural images that contain rich visual cues, manga line art consists only of sparse black-and-white strokes, making it challenging to determine which regions correspond across images. In this work, we introduce a new task: predicting region-wise correspondence between raw manga line art images without any annotations. To address this problem, we propose a Transformer-based framework trained on large-scale, automatically generated region correspondences. The model learns to suppress noisy matches and strengthen consistent structural relationships, resulting in robust patch-level feature alignment within and across images. During inference, our method segments each line art and establishes coherent region-level correspondences through edge-aware clustering and region matching. We construct manually annotated benchmarks for evaluation, and experiments across multiple datasets demonstrate both high patch-level accuracy and strong region-level correspondence performance, achieving 78.4-84.4% region-level accuracy. These results highlight the potential of our method for real-world manga and animation applications.
Gau-Occ: Geometry-Completed Gaussians for Multi-Modal 3D Occupancy Prediction
Chengxin Lv, Yihui Li, Hongyu Yang, Yunhong Wang
3D semantic occupancy prediction is crucial for autonomous driving, yet vision-only approaches suffer from weak geometric cues, and existing multi-modal frameworks often depend on dense voxel or BEV tensors that impose heavy computational cost. We present Gau-Occ, a multi-modal framework that models the scene as a compact collection of semantic 3D Gaussians, enabling geometry-guided fusion without dense volumetric processing. To enhance geometric completeness, a learned LiDAR Completion Diffuser (LCD) trained on real-world priors recovers missing structures from sparse LiDAR, and the completed points are encoded as semantic Gaussian anchors. To further integrate multi-view image semantics, we introduce Gaussian Anchor Fusion (GAF), a geometry-aligned aggregation module that performs anchor-guided 2D sampling, local neighborhood encoding, and cross-modal alignment. By constructing locally aggregated Gaussian descriptors that capture spatial consistency and semantic discriminability, GAF facilitates accurate feature association across modalities. Through anchor-driven refinement of Gaussian attributes, Occ-GS supports detailed 3D occupancy prediction. Extensive experiments across challenging benchmarks demonstrate that Occ-GS achieves state-of-the-art performance.
Monocular Open Vocabulary Occupancy Prediction for Indoor Scenes
Changqing Zhou, Yueru Luo, Han Zhang, Zeyu Jiang, Changhao Chen
Open-vocabulary 3D occupancy is vital for embodied agents, which need to understand complex indoor environments where semantic categories are abundant and evolve beyond fixed taxonomies. While recent work has explored open-vocabulary occupancy in outdoor driving scenarios, such methods transfer poorly indoors, where geometry is denser, layouts are more intricate, and semantics are far more fine-grained. To address these challenges, we adopt a geometry-only supervision paradigm that uses only binary occupancy labels (occupied vs. free). Our framework builds upon 3D Language-Embedded Gaussians, which serve as a unified intermediate representation coupling fine-grained 3D geometry with a language-aligned semantic embedding. On the geometry side, we find that existing Gaussian-to-Occupancy operators fail to converge under such weak supervision, and we introduce an opacity-aware, Poisson-based approach that stabilizes volumetric aggregation. On the semantic side, direct alignment between rendered features and open-vocabulary segmentation features suffers from feature mixing; we therefore propose a Progressive Temperature Decay schedule that gradually sharpens opacities during splatting, strengthening Gaussian-language alignment. On Occ-ScanNet, our framework achieves 59.50 IoU and 21.05 mIoU in the open-vocabulary setting, surpassing all existing occupancy methods in IoU and outperforming prior open-vocabulary approaches by a large margin in mIoU. Code will be released at https://github.com/JuIvyy/LegoOcc.
Flow3r: Factored Flow Prediction for Scalable Visual Geometry Learning
Zhongxiao Cong, Qitao Zhao, Minsik Jeon, Shubham Tulsiani
Current feed-forward 3D/4D reconstruction systems rely on dense geometry and pose supervision - expensive to obtain at scale and particularly scarce for dynamic real-world scenes. We present Flow3r, a framework that augments visual geometry learning with dense 2D correspondences ('flow') as supervision, enabling scalable training from unlabeled monocular videos. Our key insight is that the flow prediction module should be factored: predicting flow between two images using geometry latents from one and pose latents from the other. This factorization directly guides the learning of both scene geometry and camera motion, and naturally extends to dynamic scenes. In controlled experiments, we show that factored flow prediction outperforms alternative designs and that performance scales consistently with unlabeled data. Integrating factored flow into existing visual geometry architectures and training with 800K unlabeled videos, Flow3r achieves state-of-the-art results across eight benchmarks spanning static and dynamic scenes, with its largest gains on in-the-wild dynamic videos where labeled data is most scarce.
An Instance-Centric Panoptic Occupancy Prediction Benchmark for Autonomous Driving
Yi Feng, Junwu E, Zizhan Guo, Yu Ma, Hanli Wang, Rui Fan
Panoptic occupancy prediction aims to jointly infer voxel-wise semantics and instance identities within a unified 3D scene representation. Nevertheless, progress in this field remains constrained by the absence of high-quality 3D mesh resources, instance-level annotations, and physically consistent occupancy datasets. Existing benchmarks typically provide incomplete and low-resolution geometry without instance-level annotations, limiting the development of models capable of achieving precise geometric reconstruction, reliable occlusion reasoning, and holistic 3D understanding. To address these challenges, this paper presents an instance-centric benchmark for the 3D panoptic occupancy prediction task. Specifically, we introduce ADMesh, the first unified 3D mesh library tailored for autonomous driving, which integrates over 15K high-quality 3D models with diverse textures and rich semantic annotations. Building upon ADMesh, we further construct CarlaOcc, a large-scale, physically consistent panoptic occupancy dataset generated using the CARLA simulator. This dataset contains over 100K frames with fine-grained, instance-level occupancy ground truth at voxel resolutions as fine as 0.05 m. Furthermore, standardized evaluation metrics are introduced to quantify the quality of existing occupancy datasets. Finally, a systematic benchmark of representative models is established on the proposed dataset, which provides a unified platform for fair comparison and reproducible research in the field of 3D panoptic perception. Code and dataset are available at https://mias.group/CarlaOcc.
From Spots to Pixels: Dense Spatial Gene Expression Prediction from Histology Images
Ruikun Zhang, Yan Yang, Liyuan Pan
Spatial transcriptomics (ST) measures gene expression at fine-grained spatial resolution, offering insights into tissue molecular landscapes. Previous methods for spatial gene expression prediction typically crop spots of interest from histopathology slide images, and train models to map each spot to a corresponding gene expression profile. However, these methods inherently lose the spatial resolution in gene expression:1) each spot often contains multiple cells with distinct gene expression profiles;2) spots are typically defined at fixed spatial resolutions, limiting the ability to predict gene expression at varying scales. To address these limitations, this paper presents PixNet, a dense prediction network capable of predicting spatially resolved gene expression across spots of varying sizes and scales directly from histopathology slide images. Different from previous methods that map individual spots to gene expression values, we generate a spatially dense continuous gene expression map from the histopathology slide image, and aggregate values within spots of interest to predict the gene expression. Our PixNet outperforms state-of-the-art methods on four common ST datasets in multiple spatial scales. The source code is available at: https://github.com/wangzrk/From-Spots-to-Pixels.
Dr.Occ: Depth- and Region-Guided 3D Occupancy from Surround-View Cameras for Autonomous Driving
Xubo Zhu, Haoyang Zhang, Fei He, Rui Wu, Yanhu Shan, Wen Yang, Huai Yu
3D semantic occupancy prediction is crucial for autonomous driving perception, offering comprehensive geometric scene understanding and semantic recognition. However, existing methods struggle with geometric misalignment in view transformation due to lack of pixel-level accurate depth estimation, and severe spatial class imbalance where semantic categories exhibit strong spatial anisotropy. To address these challenges, we propose Dr.Occ, a depth- and region-guided occupancy prediction framework. Specifically, we introduce a depth-guided 2D-to-3D View Transformer (D-VFormer) that effectively leverages high-quality dense depth cues from MoGe-2 to construct reliable geometric priors, thereby enabling precise geometric alignment of voxel features. Moreover, inspired by the Mixture-of-Experts (MoE) framework, we propose a region-guided Expert Transformer (R/R-EFormer) that adaptively allocates region-specific experts to focus on different spatial regions, effectively addressing spatial semantic variations. Thus, the two components make complementary contributions: depth guidance ensures geometric alignment, while region experts enhance semantic learning. Experiments on the Occ3D--nuScenes benchmark demonstrate that Dr.Occ improves the strong baseline BEVDet4D by 7.43% mIoU and 3.09% IoU under the full vision-only setting.