ICLR 2026 Papers

International Conference on Learning Representations

Decision breakdown

5,358papers

Counted from the official paper list; may differ slightly from the number the conference announced.

  • Oral
    2244.2%
  • Poster
    5,13495.8%

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Animating the Uncaptured: Humanoid Mesh Animation with Video Diffusion Models

Marc Benedí San Millán, Angela Dai, Matthias Nießner

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Animation of humanoid characters is essential in various graphics applications, but require significant time and cost to create realistic animations. We propose an approach to synthesize 4D animated sequences of input static 3D humanoid meshes, leveraging strong generalized motion priors from generative video models -- as such video models contain powerful motion information covering a wide variety of human motions. From an input static 3D humanoid mesh and a text prompt describing the desired animation, we synthesize a corresponding video conditioned on a rendered image of the 3D mesh. We then employ an underlying SMPL representation to animate the corresponding 3D mesh according to the video-generated motion, based on our motion optimization. This enables a cost-effective and accessible solution to enable the synthesis of diverse and realistic 4D animations

Poster
EgoBrain: Synergizing Minds and Eyes For Human Action Understanding

Nie Lin, Yansen Wang, Dongqi Han, Weibang Jiang, Jingyuan Li, Ryosuke Furuta, Yoichi Sato, Dongsheng Li

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The integration of brain-computer interfaces (BCIs), in particular electroencephalography (EEG), with artificial intelligence (AI) has shown tremendous promise in decoding human cognition and behavior from neural signals. In particular, the rise of multimodal AI models have brought new possibilities that have never been imagined before. Here, we present EgoBrain—the world’s first large-scale, temporally aligned multimodal dataset that synchronizes egocentric vision and EEG of human brain over extended periods of time, establishing a new paradigm for human-centered behavior analysis. This dataset comprises 61 hours of synchronized 32-channel EEG recordings and first-person video from 40 participants engaged in 29 categories of daily activities. We then developed a multimodal learning framework to fuse EEG and vision for action understanding, validated across both cross-subject and cross-environment challenges, achieving an action recognition accuracy of 66.70%. EgoBrain paves the way for a unified framework for brain-computer interface with multiple modalities. All data, tools, and acquisition protocols together with the source code are openly shared to foster open science in cognitive computing.

Poster
Vision Language Models are Biased

An Vo, Khai-Nguyen Nguyen, Mohammad Reza Taesiri, Vy Tuong Dang, Anh Totti Nguyen, Daeyoung Kim

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Large language models (LLMs) memorize a vast amount of prior knowledge from the Internet that helps them on downstream tasks but also may notoriously sway their outputs towards wrong or biased answers. In this work, we test how the knowledge about popular subjects hurt the accuracy of vision language models (VLMs) on standard, objective visual tasks of counting and identification. We find that state-of-the-art VLMs are strongly biased (e.g., unable to recognize the 4th stripe has been added to a 3-stripe Adidas logo) scoring an average of 17.05% accuracy in counting (e.g., counting stripes in an Adidas-like logo) across 7 diverse domains from animals, logos, chess, game boards, optical illusions, to patterned grids. Removing image backgrounds nearly doubles accuracy (21.09 points), revealing that background visual cues trigger these biased responses. Further analysis of VLMs’ reasoning patterns shows that counting accuracy initially rises with thinking tokens, reaching ∼40%, before declining with model overthinking. Our work presents an interesting failure mode in VLMs and a human-supervised automated framework for testing VLM biases.

Poster
From Pixels to Words -- Towards Native Vision-Language Primitives at Scale

Haiwen Diao, Mingxuan Li, Silei Wu, Linjun Dai, Xiaohua Wang, Hanming Deng, Lewei Lu, Dahua Lin, Ziwei Liu

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The edifice of native Vision-Language Models (VLMs) has emerged as a rising contender to typical modular VLMs, shaped by evolving model architectures and training paradigms. Yet, two lingering clouds cast shadows over its widespread exploration and promotion: (-) What fundamental constraints set native VLMs apart from modular ones, and to what extent can these barriers be overcome? (-) How to make research in native VLMs more accessible and democratized, thereby accelerating progress in the field. In this paper, we clarify these challenges and outline guiding principles for constructing native VLMs. Specifically, one native VLM primitive should: (i) effectively align pixel and word representations within a shared semantic space; (ii) seamlessly integrate the strengths of formerly separate vision and language modules; (iii) inherently embody various cross-modal properties that support unified vision-language encoding, aligning, and reasoning. Hence, we launch NEO, a novel family of native VLMs built from first principles, greatly narrowing the gap with top-tier modular counterparts across diverse real-world scenarios. With only 390M image-text examples, NEO efficiently develops visual perception from scratch while mitigating vision-language conflicts inside a dense and monolithic model crafted from our elaborate primitives. We position NEO as a cornerstone for scalable and powerful native VLM development, paired with a rich set of reusable components that foster a cost-effective and extensible ecosystem. Code and weights will be publicly available to promote further research.

Poster
BiasBusters: Uncovering and Mitigating Tool Selection Bias in Large Language Models

Thierry Blankenstein, Jialin Yu, Zixuan Li, Vassilis Plachouras, Sunando Sengupta, Philip Torr, Yarin Gal, Alasdair Paren, Adel Bibi

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Agents backed by large language models (LLMs) often rely on external tools drawn from marketplaces where multiple providers offer functionally equivalent options. This raises a critical point concerning fairness: if selection is systematically biased, it can degrade user experience and distort competition by privileging some providers over others. We introduce a benchmark of diverse tool categories, each containing multiple functionally equivalent tools, to evaluate tool-selection bias. Using this benchmark, we test seven models and show that unfairness exists with models either fixating on a single provider or disproportionately preferring earlier-listed tools in context. To investigate the origins of this bias, we conduct controlled experiments examining tool features, metadata (name, description, parameters), and pre-training exposure. We find that: (1) semantic alignment between queries and metadata is the strongest predictor of choice; (2) perturbing descriptions significantly shifts selections; and (3) repeated pre-training exposure to a single endpoint amplifies bias. Finally, we propose a lightweight mitigation that first filters the candidate tools to a relevant subset and then samples uniformly, reducing bias while preserving good task coverage. Our findings highlight tool-selection bias as a key obstacle for the fair deployment of tool-augmented LLMs.

Poster
sleep2vec: Unified Cross-Modal Alignment for Heterogeneous Nocturnal Biosignals

Weixuan Yuan, Zengrui Jin, Yichen Wang, Donglin Xie, Ziyi Ye, Chao Zhang, Xuesong Chen

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Tasks ranging from sleep staging to clinical diagnosis traditionally rely on standard polysomnography (PSG) devices, bedside monitors and wearable devices, which capture diverse nocturnal biosignals (e.g., EEG, EOG, ECG, SpO$_2$). However, heterogeneity across devices and frequent sensor dropout pose significant challenges for unified modelling of these multimodal signals. We present sleep2vec, a foundation model for diverse and incomplete nocturnal biosignals that learns a shared representation via cross-modal alignment. sleep2vec is contrastively pre-trained on 42,249 overnight recordings spanning nine modalities using a Demography, Age, Site & History-aware InfoNCE objective that incorporates physiological and acquisition metadata (e.g., age, gender, recording site) to dynamically weight negatives and mitigate cohort-specific shortcuts. On downstream sleep staging and clinical outcome assessment, sleep2vec consistently outperforms strong baselines and remains robust to any subset of available modalities and sensor dropout. We further characterize, to our knowledge for the first time, scaling laws for nocturnal biosignals with respect to modality diversity and model capacity. Together, these results show that unified cross-modal alignment, coupled with principled scaling, enables label-efficient, general-purpose modelling of real-world nocturnal biosignals.

Poster
Completing Missing Annotation: Multi-Agent Debate for Accurate and Scalable Relevant Assessment for IR Benchmarks

Minjeong Ban, Jeonghwan Choi, Hyangsuk Min, Nicole Hee-Yeon Kim, Minseok Kim, Jae-Gil Lee, Hwanjun Song

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Information retrieval (IR) evaluation remains challenging due to incomplete IR benchmark datasets that contain unlabeled relevant chunks. While LLMs and LLM-human hybrid strategies reduce costly human effort, they remain prone to LLM overconfidence and ineffective AI-to-human escalation. To address this, we propose DREAM, a multi-round debate-based relevance assessment framework with LLM agents, built on opposing initial stances and iterative reciprocal critique. Through our agreement-based debate, it yields more accurate labeling for certain cases and more reliable AI-to-human escalation for uncertain ones, achieving 95.2% labeling accuracy with only 3.5% human involvement. Using DREAM, we build BRIDGE, a refined benchmark that mitigates evaluation bias and enables fairer retriever comparison by uncovering 29,824 missing relevant chunks. We then re-benchmark IR systems and extend evaluation to RAG, showing that unaddressed holes not only distort retriever rankings but also drive retrieval–generation misalignment. Code and data will be released upon acceptance.

Poster
SAGE: Spatial-visual Adaptive Graph Exploration for Efficient Visual Place Recognition

Shunpeng Chen, Changwei Wang, Rongtao Xu, Peixingtian, Yukun Song, Jinzhou Lin, Wenhao XU, jingyizhang, Li Guo, Shibiao Xu

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Visual Place Recognition (VPR) requires robust retrieval of geotagged images despite large appearance, viewpoint, and environmental variation. Prior methods focus on descriptor fine-tuning or fixed sampling strategies yet neglect the dynamic interplay between spatial context and visual similarity during training. We present SAGE ($\underline{S}$patial-visual $\underline{A}$daptive $\underline{G}$raph $\underline{E}$xploration), a unified training pipeline that enhances granular spatial–visual discrimination by jointly improving local feature aggregation, organize samples during training, and hard sample mining. We introduce a lightweight Soft Probing module that learns residual weights from training data for patch descriptors before bilinear aggregation, boosting distinctive local cues. During training we reconstruct an online geo–visual graph that fuses geographic proximity and current visual similarity so that candidate neighborhoods reflect the evolving embedding landscape. To concentrate learning on the most informative place neighborhoods, we seed clusters from high-affinity anchors and iteratively expand them with a greedy weighted clique expansion sampler. Implemented with a frozen DINOv2 backbone and parameter-efficient fine-tuning, SAGE achieves SOTA across eight benchmarks. Notably, our method obtains 100\% Recall@10 on SPED only using 4096D global descriptors. The code and model are available at https://github.com/chenshunpeng/SAGE.

Poster
Continual Low-Rank Adapters for LLM-based Generative Recommender Systems

Hyunsik Yoo, Ting-Wei Li, SeongKu Kang, Zhining Liu, Charlie Xu, Qilin Qi, Hanghang Tong

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While large language models (LLMs) achieve strong performance in recommendation, they face challenges in continual learning as users, items, and user preferences evolve over time. Existing LoRA-based continual methods primarily focus on preserving performance on previous tasks, but this overlooks the unique nature of recommendation: the goal is not to predict past preferences, and outdated preferences can even harm performance when current interests shift significantly. To address this, we propose PESO (Proximally rEgularized Single evolving lOra, a continual adaptation method for LoRA in recommendation. PESO introduces a proximal regularizer that anchors the current adapter to its most recent frozen state, enabling the model to flexibly balance adaptation and preservation, and to better capture recent user behaviors. Theoretically, we show that this proximal design provides data-aware, direction-wise guidance in the LoRA subspace. Empirically, PESO consistently outperforms existing LoRA-based continual learning methods.

Poster
Shift-and-Sum Quantization for Visual Autoregressive Models

Jaehyeon Moon, Bumsub Ham

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Post-training quantization (PTQ) enables efficient deployment of deep networks using a small set of data. Its application to visual autoregressive models (VAR), however, remains relatively unexplored. We identify two key challenges for applying PTQ to VAR: (i) large reconstruction errors in attention–value products, especially at coarse scales where high attention scores occur more frequently; and (ii) a discrepancy between the sampling frequencies of codebook entries and their predicted probabilities due to limited calibration data. To address these challenges, we propose a PTQ framework tailored for VAR. First, we introduce a shift-and-sum quantization method that reduces reconstruction errors by aggregating quantized results from symmetrically shifted duplicates of value tokens. Second, we present a resampling strategy for calibration data that aligns sampling frequencies of codebook entries with their predicted probabilities. Experiments on class-conditional image generation, in-painting, out-painting, and class-conditional editing show consistent improvements across VAR architectures, establishing a new state of the art in PTQ for VAR.

Poster
TD-MoE: Tensor Decomposition for MoE Models

Yuebin XU, YANHONG WANG, Xuemei Peng, Hui Zang, Chen Minghao, Pengfei Xia, Zeyi Wen

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Mixture-of-Experts (MoE) architectures have demonstrated remarkable capabilities and scalability for large language models, but incur a prohibitive memory footprint due to duplicated expert parameters. Existing compression approaches, particularly those based on low-rank decomposition, typically operate at the granularity of individual experts. However, such per-expert methods overlook structural redundancies across experts, limiting their compression efficiency and effectiveness. In this work, we introduce TD-MoE (Tensor Decomposition for MoE Compression), a data-aware framework that jointly and holistically factorizes expert weights. Our contributions are threefold: (i) Cross-expert tensorization with joint 3D decomposition, which unifies all experts within a layer into a single tensor and captures shared structure beyond per-expert scope; (ii) A multi-linear whitening strategy, which decorrelates input and output features, yielding a more balanced and data-adaptive decomposition; (iii) A 3D rank allocation mechanism, which dynamically assigns 3D decomposition ranks across dimensions to best meet a target compression ratio while minimizing the reconstruction error. Extensive experiments on Qwen2-57B-A14 and Mixtral-8×7B across seven commonsense reasoning benchmarks demonstrate that TD-MoE achieves almost lossless performance under 20\% parameter reduction, and delivers more than 11\% and 14\% gains over state-of-the-art decomposition-based baselines at 40\% and 60\% compression. Further ablation studies validate the effectiveness of each component, highlighting the importance of joint factorization, whitening, and rank allocation. The code is available at \href{https://anonymous.4open.science/r/TD-MoE}{https://anonymous.4open.science/r/TD-MoE}.

Poster
Cite Pretrain: Retrieval-Free Knowledge Attribution for Large Language Models

Yukun Huang, Sanxing Chen, Jian Pei, Manzil Zaheer, Bhuwan Dhingra

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Trustworthy language models should provide both correct and verifiable answers. However, citations generated directly by standalone LLMs are often unreliable due to hallucinations. As a result, current systems insert citations by querying an external retriever at inference time, introducing latency, infrastructure dependence, and vulnerability to retrieval noise. We explore whether LLMs can be made to reliably attribute to the documents seen during (continual) pretraining, without test‑time retrieval, by revising the training process. To study this, we construct **CitePretrainBench**, a benchmark that mixes real‑world corpora (Wikipedia, Common Crawl, arXiv) with novel, unseen documents and probes both short‑form (single fact) and long‑form (multi‑fact) citation tasks. Our approach follows a two-stage process: (1) Continual-pretraining to index factual knowledge by binding it to persistent document identifiers; (2) Instruction tuning to elicit citation behavior. We introduce **Active Indexing** for the first stage, which creates generalizable, source-anchored bindings by augmenting training with synthetic data that (i) restate each fact in diverse, compositional forms and (ii) enforce bidirectional training (source$\to$fact and fact$\to$source). This equips the model to both generate content from a cited source and attribute its own answers, improving robustness to paraphrase and composition. Experiments with Qwen‑2.5‑7B and 3B show that Active Indexing consistently outperforms a Passive Indexing baseline, which simply appends an identifier to each document, achieving citation precision gains of up to 30.2\% across all tasks and models. Our ablation studies reveal that performance continues to improve as we scale the amount of augmented data, showing a clear upward trend even at 16× the original token count. Finally, we show that internal citations complement external ones by making the model more robust to retrieval noise.

Poster
Product-Quantised Image Representation for High-Quality Image Synthesis

Denis Zavadski, Nikita Philip Tatsch, Carsten Rother

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Product quantisation (PQ) is a classical method for scalable vector encoding, yet it has seen limited usage for latent representations in high-fidelity image generation. In this work, we introduce PQGAN, a quantised image autoencoder that integrates PQ into the well-known vector quantisation (VQ) framework of VQGAN. PQGAN achieves a noticeable improvement over state-of-the-art methods in terms of reconstruction performance, including both quantisation methods and their continuous counterparts. We achieve a PSNR score of 37dB, where prior work achieves 27dB, and are able to reduce the FID, LPIPS, and CMMD score by up to 96\%. Our key to success is a thorough analysis of the interaction between codebook size, embedding dimensionality, and subspace factorisation, with vector and scalar quantisation as special cases. We obtain novel findings, such that the performance of VQ and PQ behaves in opposite ways when scaling the embedding dimension. Furthermore, our analysis shows performance trends for PQ that help guide optimal hyperparameter selection. Finally, we demonstrate that PQGAN can be seamlessly integrated into pre-trained diffusion models. This enables either a significantly faster and more compute-efficient generation, or a doubling of the output resolution at no additional cost, positioning PQ as a strong extension for discrete latent representation in image synthesis.

Poster
Beyond Real: Imaginary Extension of Rotary Position Embeddings for Long-Context LLMs

Xiaoran Liu, Yuerong Song, Zhigeng Liu, Zengfeng Huang, Qipeng Guo, Zhaoxiang Liu, Shiguo Lian, Ziwei He, Xipeng Qiu

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Rotary Position Embeddings (RoPE) have become a standard for encoding sequence order in Large Language Models (LLMs) by applying rotations to query and key vectors in the complex plane. Standard implementations, however, utilize only the real component of the complex-valued dot product for attention score calculation. This simplification discards the imaginary component, which contains valuable phase information, leading to a potential loss of relational details crucial for modeling long-context dependencies. In this paper, we propose an extension that re-incorporates this discarded imaginary component. Our method leverages the full complex-valued representation to create a dual-component attention score. We theoretically and empirically demonstrate that this approach enhances the modeling of long-context dependencies by preserving more positional information. Furthermore, evaluations on a suite of long-context language modeling benchmarks show that our method consistently improves performance over the standard RoPE, with the benefits becoming more significant as context length increases. The code is available at https://github.com/OpenMOSS/rope_pp.

Poster
Deconstructing Positional Information: From Attention Logits to Training Biases

Zihan Gu, Ruoyu Chen, Han Zhang, Hua Zhang, Yue Hu

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Positional encodings, a mechanism for incorporating sequential information into the Transformer model, are central to contemporary research on neural architectures. Previous work has largely focused on understanding their function through the principle of distance attenuation, where proximity dictates influence. However, the interaction between positional and semantic information remains insufficiently explored, and the complexity of mainstream corpora hinders systematic, comparative studies of these methods. This paper addresses these challenges through a deconstruction of the attention-logit computation and a structured analysis of all mainstream positional encodings. A key focus is placed on Rotary Positional Embedding (RoPE), whose product-based structure uniquely facilitates a direct interaction between position and content. To probe this characteristic, we designed a novel synthetic task that explicitly demands a strong synthesis of positional and semantic information. As theoretically predicted, RoPE demonstrates a significant performance advantage over other encodings on this specialized task. Concurrently, this targeted evaluation uncovers an implicit training issue: a hidden bias manifesting as a distinct information aggregation phenomenon in the model's shallow layers, which we term the "single-head deposit pattern." Through subsequent ablation studies, we analyze this pattern and identify a method for its mitigation. These findings highlight the need for a deeper investigation into the training dynamics of positional encodings to bridge the gap between their theoretical design and practical implementation.

Poster
Is This Just Fantasy? Language Model Representations Reflect Human Judgments of Event Plausibility

Michael A. Lepori, Jennifer Hu, Ishita Dasgupta, Roma Patel, Thomas Serre, Ellie Pavlick

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Language models (LMs) are used for a diverse range of tasks, from question answering to writing fantastical stories. In order to reliably accomplish these tasks, LMs must be able to discern the modal category of a sentence (i.e., whether it describes something that is possible, impossible, completely nonsensical, etc.). However, recent studies have called into question the ability of LMs to categorize sentences according to modality. In this work, we identify linear representations that discriminate between modal categories within a variety of LMs, or modal difference vectors. Analysis of modal difference vectors reveals that LMs have access to more reliable modal categorization judgments than previously reported. Furthermore, we find that modal difference vectors emerge in a consistent order as models become more competent (i.e., through training steps, layers, and parameter count). Notably, we find that modal difference vectors identified within LM activations can be used to model fine-grained human categorization behavior. This potentially provides a novel view into how human participants distinguish between modal categories, which we explore by correlating projections along modal difference vectors with human participants' ratings of interpretable features. In summary, we derive new insights into LM modal categorization using techniques from mechanistic interpretability, with the potential to inform our understanding of modal categorization in humans.

Poster
Learning Domain-Aware Task Prompt Representations for Multi-Domain All-in-One Image Restoration

Guanglu Dong, Chunlei Li, Chao Ren, Jingliang Hu, Yilei Shi, Xiao Xiang Zhu, Lichao Mou

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Recently, significant breakthroughs have been made in all-in-one image restoration (AiOIR), which can handle multiple restoration tasks with a single model. However, existing methods typically focus on a specific image domain, such as natural scene, medical imaging, or remote sensing. In this work, we aim to extend AiOIR to multiple domains and propose the first multi-domain all-in-one image restoration method, DATPRL-IR, based on our proposed Domain-Aware Task Prompt Representation L}earning. Specifically, we first construct a task prompt pool containing multiple task prompts, in which task-related knowledge is implicitly encoded. For each input image, the model adaptively selects the most relevant task prompts and composes them into an instance-level task representation via a prompt composition mechanism (PCM). Furthermore, to endow the model with domain awareness, we introduce another domain prompt pool and distill domain priors from multimodal large language models into the domain prompts. PCM is utilized to combine the adaptively selected domain prompts into a domain representation for each input image. Finally, the two representations are fused to form a domain-aware task prompt representation which can make full use of both specific and shared knowledge across tasks and domains to guide the subsequent restoration process. Extensive experiments demonstrate that our DATRL-IR significantly outperforms existing SOTA image restoration methods, while exhibiting strong generalization capabilities. We believe that this work provides a new research paradigm and represents a step towards more unified image restoration.

Poster
TS$^2$: Training with Sparsemax+, Testing with Softmax for Accurate and Diverse LLM Fine-Tuning

XuZiyang, Ananthu Rajendran Pillai, Yinghua Yao, Yuangang Pan

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Large Language Models (LLMs) typically rely on Supervised Fine-Tuning (SFT) with Cross-Entropy (CE) loss to specialize in downstream tasks. However, CE forces the distribution toward one-hot targets and ignores alternative continuations, thereby limiting output diversity—a key drawback for generative applications that rely on sampling-based exploration. In this paper, we propose ``Training with Sparsemax+, Testing with Softmax (TS$^2$)''. Intuitively, sparsemax and its tailored loss mask the gradients of probabilities outside the support set, leaving excessive probability mass on irrelevant tail classes when evaluating with softmax. To address this issue, we propose an improved variant, Sparsemax+, for training, which augments the sparsemax loss with a suppression term that penalizes the out-of-support probabilities. At testing, we decode with softmax, yielding calibrated, non-degenerate probabilities where plausible near-ties survive. We fine-tuned Llama-3.1-8B and Qwen-2.5-7B with TS$^2$, achieving consistent improvements in accuracy and output diversity across chat, code, and open-domain benchmarks. Together, these results demonstrate that TS$^2$ provides a practical, drop-in solution for fine-tuning LLMs that are both more accurate and more creative.

Poster
Paper Copilot: Tracking the Evolution of Peer Review in AI Conferences

Jing Yang, Qiyao Wei, Jiaxin Pei

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Submissions are rising fast, and venues use different rules, data formats, and update times. As a result, signals of progress get split across places, and key moments (rebuttal, discussion, final decision) are easy to miss, making analysis hard. We present Paper Copilot, a system and scalable peer-review archive that pulls data from official sites, OpenReview, and opt-in forms into a single, standardized, versioned record with timestamps. This lets us track trends over time and compare venues, institutions, and countries in a consistent way. Using the archive for ICLR 2024/2025, we see larger score changes after rebuttal for higher-tier papers, reviewer agreement that dips during active discussion and tightens by the end, and in 2025 a sharper, mean-score–driven assignment of tiers with lower decision uncertainty than expected at that scale. We also state simple rules for ethics—clear sourcing and consent, privacy protection, and limits on use for closed venues. Together, we provide a clear, reusable base for tracking AI/ML progress, and, with this data, enable validation, benchmarking, and otherwise hard-to-run studies.

Poster
Adaptive Data-Knowledge Alignment in Genetic Perturbation Prediction

Yuanfang Xiang, Lun Ai

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The transcriptional response to genetic perturbation reveals fundamental insights into complex cellular systems. While current approaches have made progress in predicting genetic perturbation responses, they provide limited biological understanding and cannot systematically refine existing knowledge. Overcoming these limitations requires an end-to-end integration of data-driven learning and existing knowledge. However, this integration is challenging due to inconsistencies between data and knowledge bases, such as noise, misannotation, and incompleteness. To address this challenge, we propose ALIGNED (Adaptive aLignment for Inconsistent Genetic kNowledgE and Data), a neuro-symbolic framework based on the Abductive Learning (ABL) paradigm. This end-to-end framework aligns neural and symbolic components and performs systematic knowledge refinement. We introduce a balanced consistency metric to evaluate the predictions' consistency against both data and knowledge. Our results show that ALIGNED outperforms state-of-the-art methods by achieving the highest balanced consistency, while also re-discovering biologically meaningful knowledge. Our work advances beyond existing methods to enable both the transparency and the evolution of mechanistic biological understanding.

Poster