CVPR 2026 Papers

Conference on Computer Vision and Pattern Recognition

Decision breakdown

4,042papers

Counted from the official paper list; may differ slightly from the number the conference announced.

  • Oral
    1383.4%
  • Poster
    3,90496.6%

Browse all papers

Plug-and-Play Incomplete Multi-View Clustering via Janus-Faced Affinity Learning with Topology Harmonization

Shengju Yu, Suyuan Liu, Wenhao SHAO, Siwei Wang, KE LIANG, Xihong Yang, Tiejun Li, Xinwang Liu

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Prevailing incomplete multi-view clustering (IMVC) approaches typically fail to account for the interference of view-exclusive artifacts when learning view-consensus representations, which could compromise the fidelity of the resulting similarity measure. Moreover, inconsistencies in anchor order across views may distort the graph structure, impairing the clustering performance. The reliance on carefully-tuned regularization hyper-parameters also usually undermines the model's practical utility. To alleviate these issues, we propose a plug-and-play IMVC framework named PJFTH that incorporates Janus-faced affinity learning with topology harmonization. It explicitly models the exclusive-to-consensus interplay, derives a view-private graph from each view, and adaptively integrates them into a global consensus affinity according to the respective view's intrinsic characteristics. Furthermore, a permutation transformation with unary encoding constraints is applied to anchor matrix, realigning anchor topology while preserving the values. This process synchronizes anchor order prior to similarity integration and maintains original anchor properties. Notably, all components are coupled seamlessly and optimized in a joint manner. Also, the provable overall linear complexity further enlarges its scalability and practicality. Experimental results confirm that PJFTH receives competitive performance compared to several leading methods.

Poster
GMT: Effective Global Framework for Multi-Camera Multi-Target Tracking

Yihao Zhen, Mingyue Xu, Qiang Wang, Baojie Fan, Jiahua Dong, Tinghui Zhao, Huijie Fan

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Existing Multi-Camera Multi-Target (MCMT) tracking models typically adopt a two-stage framework, involving single-camera tracking followed by inter-camera tracking. However, in this paradigm, the use of multiple views is confined to recovering missed matches in the first stage, providing a limited contribution to overall tracking. To address this issue, we propose a novel global MCMT tracking framework termed GMT, which effectively leverages the advantage of multi-view by performing global-level trajectory-target matching. Specifically, instead of assigning trajectories independently for each view, we propose a Cross-View Feature Consistency Enhancement(CFCE) module to reduce the feature discrepancies across different views, and encode the same historical targets across different views as global trajectories. The Global Trajectory Associate (GTA) module is then introduced to associate new targets to global trajectories, allowing the model to jointly exploit both intra-view and inter-view cues during tracking. Compared with the two-stage framework, the GMT achieves significant improvements on existing datasets, with gains of up to 13.1% in CVMA in and 19.2% in CVIDF1. Moreover, we present VisionTrack, a high-quality, large-scale MCMT dataset encompassing diverse scenes with varying illumination and target distributions, providing significantly greater diversity than existing datasets. Our code and dataset will be released at https://github.com/FoxCanned/GMT.

Poster
ALLNet: Multi-task Dense Prediction for Degraded Images

Weiran Wang, Jialing Wu, Yaqi Chang, Gang He, Li Xu, Chang Wu, Yunsong Li

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Multi-taskdensepredictionaims tosimultaneously addressmultiplepixel-level tasksthroughaunifiednetworkforvisualsceneunderstanding.However,adverse environmental conditions limit thegeneralizationand practicality of such tasks. Toaddress this, we proposeALLNet, anovel framework that effectively explores degradationpatterns and integratesmulti-task collaborative information. Specifically, we designa MoE-basedMixtureofAdaptiveExperts(MaE)restorationcomponentnetworkthatenhancesdegradationfeaturesthroughdynamicroutingandguidestask-specific featureextraction. Furthermore,weformulateaTaskawareCollaborativeRefinement (TCR)moduletocaptureglobalsemanticcorrelationsandcross-taskdependencies,facilitatingbidirectionalcollaborationbetween restorationandtask-specific featuresondegradedimages. Tothebestofourknowledge, thisrepresentsthe firstattemptatmulti-taskdensepredictionunderimage degradation.ExperimentalresultsondegradedNYUDv2andPASCAL-Contextbenchmarksdemonstratethat ourarchitecturesignificantlyoutperformsexistingmethodsindegradedscenarios.

Poster
Mamba Learns in Context: Structure-Aware Domain Generalization for Multi-Task Point Cloud Understanding

Jincen Jiang, Qianyu Zhou, Yuhang Li, Kui Su, Meili Wang, Jian Chang, Jian Jun Zhang, Xuequan Lu

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While recent Transformer and Mamba architectures have advanced point cloud representation learning, they are typically developed for single-task or single-domain settings. Directly applying them to multi-task domain generalization (DG) leads to degraded performance. Transformers effectively model global dependencies but suffer from quadratic attention cost and lack explicit structural ordering, whereas Mamba offers linear-time recurrence yet often depends on coordinate-driven serialization, which is sensitive to viewpoint changes and missing regions, causing structural drift and unstable sequential modeling. In this paper, we propose Structure-Aware Domain Generalization (SADG), a Mamba-based In-Context Learning framework that preserves structural hierarchy across domains and tasks. We design structure-aware serialization (SAS) that generates transformation-invariant sequences using centroid-based topology and geodesic curvature continuity. We further devise hierarchical domain-aware modeling (HDM) that stabilizes cross-domain reasoning by consolidating intra-domain structure and fusing inter-domain relations. At test time, we introduce a lightweight spectral graph alignment (SGA) that shifts target features toward source prototypes in the spectral domain without updating model parameters, ensuring structure-preserving test-time feature shifting. In addition, we introduce MP3DObject, a real-scan object dataset for multi-task DG evaluation. Comprehensive experiments demonstrate that the proposed approach improves structural fidelity and consistently outperforms state-of-the-art methods across multiple tasks including reconstruction, denoising, and registration.

Poster
Bridging Domains through Subspace-Aware Model Merging

Levy Chaves, Chao Zhou, Rebekka Burkholz, Eduardo Valle, Sandra Avila

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Model merging integrates multiple task-specific models into a single consolidated one. Recent research has made progress in improving merging performance for in-distribution or multi-task scenarios, but domain generalization in model merging remains underexplored. We investigate how merging models fine-tuned on distinct domains affects generalization to unseen domains. Through an analysis of parameter competition in the task matrix using singular value decomposition, we show that merging models trained under different distribution shifts induces stronger conflicts between their subspaces compared to traditional multi-task settings. To mitigate this issue, we propose SCORE (Subspace COnflict-Resolving mErging), a method designed to alleviate such singular subspace conflicts. SCORE finds a shared orthogonal basis by computing the principal components of the concatenated leading singular vectors of all models. It then projects each task matrix into the shared basis, pruning off-diagonal components to remove conflicting singular directions. SCORE consistently outperforms, on average, existing model merging approaches in domain generalization settings across a variety of architectures and model scales, demonstrating its effectiveness and scalability.

Poster
ModularAgent: A Task-Aware Modular Framework for Joint Optimization of Multimodal Large Language Models and World Models

Yu-Wei Zhan, Xin Wang, Pengzhe Mao, Tongtong Feng, Ren Wang, Wenwu Zhu

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Building generalist embodied agents requires a unified system that can interpret multimodal goals, model environment dynamics, and execute reliable actions across diverse real-world tasks. Multimodal large language models (MLLMs) offer strong semantic priors and cross-modal generalization, while world models (WMs) provide actionable latent dynamics for prediction and control. Their combination holds promise for open-ended embodied intelligence, yet introduces two key challenges: (1) establishing a tight coupling between the semantic intent from MLLMs and the dynamic state representations within the WM's latent space, and (2) achieving task-aware adaptability that supports multi-task learning and cross-environment generalization. To address these limitations, we propose ModularAgent, a task-aware dynamic joint framework that enables bidirectional coupling between MLLMs and WMs. ModularAgent establishes two complementary pathways: a forward path that injects MLLM representations into the WMs latent space for semantically guided imagination, and a backward path where WM-generated feedback refines the MLLMs semantic space via dense text-conditioned rewards. This bidirectional interaction is realized through three synergistic components: Task-Aware Dynamic Joint Learning, Task-Aware Behavior Learning, and MLLM-WM Joint Optimization, which together harmonize semantic reasoning and dynamic prediction. Extensive experiments across multi-task and cross-environment settings demonstrate superior stability and generalization over state-of-the-art baselines, marking a step toward open-ended embodied learning.

Poster
TSTM: Temporal Segmentation for Task-relevant Mask in Visual Reinforcement Learning Generalization

Weicheng Du, Wenjia Meng, Zhengzhe Zhang, Yilong Yin, Xiankai Lu

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Achieving strong policy generalization to unseen environments remains a core challenge in visual reinforcement learning, and segmenting task-relevant regions to mitigate the influence of irrelevant visual cues has emerged as a promising direction. However, existing methods rely solely on the current observation, lack temporal information, and fail to exploit preceding observations, leaving learned policies susceptible to task-irrelevant background variations and ultimately degrading policy performance. In this paper, we propose temporal segmentation for task-relevant mask in visual reinforcement learning, named TSTM, which extracts task-relevant regions from sequential observations by exploiting temporal information, thereby producing more reliable masks and improving policy generalization. TSTM introduces a temporal segmentation network with an encoder-temporal-decoder architecture, where a convolutional LSTM module captures temporal dependencies across observations. To reduce inference overhead, we further develop a lightweight student network as an efficient substitute for the teacher network. The resulting task-relevant masks are encoded by a CNN-based encoder, and invariant representation learning is employed to improve robustness by enforcing consistency between representations of the original and augmented observation sequences. With these task-relevant representations, we train an actor-critic agent to learn a policy with strong generalization capability. Experimental results demonstrate that TSTM achieves superior generalization performance over existing state-of-the-art methods on most visual RL tasks.

Poster
MER-Tracker: Towards High-Speed 3D Point Tracking via Multi-View Event-RGB Hybrid Cameras

Yiqian Chang, Qinghong Ye, Haoran Xu, Jianing Li, Dongyang Ma, Xuan Wang, Wei Zhang, Yonghong Tian, Peixi Peng

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This paper proposes the first task for high-speed 3D point tracking using multi-view Event-RGB hybrid cameras. We design a cuboid observation device comprising 4 RGB cameras (30fps) and 2 Event cameras to synchronously capture high-speed motions, and propose MER-Tracker, a high-frame-rate 3D point-tracking network that fuses the complementary strengths of dual modalities. We first respectively extract 2D motion-change features from the RGB and Event modalities, then apply linear interpolation and anchor sampling to fuse the discrete RGB 3D features and continuous Event 3D features after 3D lifting, and finally employ a LoRA-tuned Transformer based on temporal correlationship to predict the high-frame-rate 3D point trajectories over fast motions, accomplishing high-speed 3D point tracking. To verify the effectiveness of our method, we construct both real-world and simulated high-speed motion datasets. Experiments on these datasets show that our method achieves accurate high-speed 3D point tracking at high-frame-rate (150fps), outperforming state-of-the-art methods.

Poster
UnityVideo: Unified Multi-Modal Multi-Task Learning for Enhancing World-Aware Video Generation

Jiehui Huang, Yuechen ZHANG, Xu He, Yuan Gao, Zhi Cen, Bin Xia, Yan Zhou, Xin Tao, Pengfei Wan, Jiaya Jia

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Recent video generation models demonstrate impressive synthesis capabilities but remain limited by single-modality conditioning, constraining their holistic world understanding. This stems from insufficient cross-modal interaction and limited modal diversity for comprehensive world knowledge representation.To address these limitations, we introduce UnityVideo, a unified framework for world-aware video generation that jointly learns across multiple modalities--segmentation masks, human skeletons, DensePose, optical flow, and depth maps--and training paradigms. Our approach features two core components: (1) dynamic noising to unify heterogeneous training paradigms, and (2) a modality switcher with an in-context learner that enables unified processing via modular parameters and contextual learning. We contribute a large-scale unified dataset with 1.3M samples. Through joint optimization, UnityVideo accelerates convergence and significantly enhances zero-shot generalization to unseen data. We demonstrate that UnityVideo achieves superior video quality, consistency, and improved alignment with physical world constraints.

Poster
Deciphering Genotype-Phenotype Mechanisms from High-Content Profiling via Knowledge-Guided Multi-modal Graph Learning

Hanjing Lin, Jiahua Rao, Youhan Sun, Jiancong Xie, Yuedong Yang

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Understanding genotype-phenotype relationships is pivotal for advancing biomedical research, drug discovery, and precision medicine. With the rise of high-throughput cellular imaging, it is essential to tightly integrate high-content cellular morphology with structured biological knowledge to extract cellular-scale evidence for genotype-to-phenotype mapping.However, integrating high-dimensional, heterogeneous, and noisy phenotypes with structured knowledge remains challenging. Prior approaches typically treat phenotypes as node features, overlooking that phenotypes primarily convey cellular-scale relational signals about how perturbations reshape interactions. We present KERNEL, a knowledge-guided multimodal graph learning framework that integrates cellular imaging phenotypes into a unified knowledge graph to predict genotype-phenotype interactions, including GRN inference, drug-target interaction prediction, and subtype-specific subnetwork discovery. KERNEL dynamically augments task-relevant edges from noisy phenotypic signals, explicitly learns per-edge confidence and marginal utility, and uses knowledge gating to align graph topology with mechanistic pathways. Across large-scale imaging and single-cell datasets, KERNEL consistently outperforms state-of-the-art baselines, e.g., up to 38.1% AUPR improvement for GRN inference, while delivering more accurate and interpretable DTI and subtype subnetwork discovery, demonstrating robust mechanism learning from richer, harder-to-denoise phenotypes.

Poster
Let Your Image Move with Your Motion! -- Implicit Multi-Object Multi-Motion Transfer

Yuze Li, Dong Gong, Xiao Cao, Junchao Yuan, Dongsheng Li, Lei Zhou, Yun Sing Koh, Cheng Yan, Xinyu Zhang

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Motion transfer has emerged as a promising direction for controllable video generation, yet existing methods largely focus on single-object scenarios and struggle when multiple objects require distinct motion patterns. In this work, we present FlexiMMT, the first implicit image-to-video (I2V) motion transfer framework that explicitly enables multi-object, multi-motion transfer. Given a static multi-object image and multiple reference videos, FlexiMMT independently extracts motion representations and accurately assigns them to different objects, supporting flexible recombination and arbitrary motion-to-object mappings. To address the core challenge of cross-object motion entanglement, we introduce a Motion Decoupled Mask Attention Mechanism that uses object-specific masks to constrain attention, ensuring that motion and text tokens only influence their designated regions. We further propose a Differentiated Mask Propagation Mechanism that derives object-specific masks directly from diffusion attention and progressively propagates them across frames efficiently. Extensive experiments demonstrate that FlexiMMT achieves precise, compositional, and state-of-the-art performance in I2V-based multi-object multi-motion transfer. Our project page is: https://ethan- li123.github.io/FlexiMMT_page/

Poster
Discovering Adaptive Task Dependencies for Efficient Multi-Task Representation Compression

Zhimeng Huang, Rongao Yuan, Junlong Gao, Qi Mao, Siwei Ma, Wen Gao, Chuanmin Jia

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Traditional image compression prioritizes pixel fidelity but often preserves details irrelevant to downstream vision tasks. Compressing task-specific representations instead better aligns with task semantics, yet redundant information persists across correlated tasks. Existing multi-task compression methods typically rely on static dependency structures, leading to redundant bit allocation across correlated tasks and suboptimal rate-distortion performance. We present Adaptive Task Dependency Compression (ATDC), a framework that models per-image task relationships and encodes representations following an adaptive directed acyclic graph (DAG). ATDC infers pairwise task predictability via a learned correlation matrix, constructs a dynamic DAG to determine the optimal compression order, and encodes each task conditionally on its predecessors, achieving predictive redundancy removal and asymmetric information sharing across tasks. Experiments on the Taskonomy dataset demonstrate consistent gains in rate-distortion efficiency and task accuracy over both human-oriented codecs and state-of-the-art multi-task compression methods.The learned DAGs reveal interpretable, content-dependent task hierarchies, establishing adaptive dependency modeling as a principled paradigm for multi-task representation compression.

Poster
Spectrally Distilled Representations Aligned with Instruction-Augmented LLMs for Satellite Imagery

Minh Kha Do, Wei Xiang, Kang Han, Di Wu, Khoa Phan, Yi-Ping Phoebe Chen, Gaowen Liu, Ramana Rao Kompella

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Vision-language foundation models (VLFMs) promise zero-shot and retrieval understanding for Earth observation. While operational satellite systems often lack full multi-spectral coverage, making RGB-only inference highly desirable for scalable deployment, the adoption of VLFMs for satellite imagery remains hindered by two factors: (1) multi-spectral inputs are informative but difficult to exploit consistently due to band redundancy and misalignment; and (2) CLIP-style text encoders limit semantic expressiveness and weaken fine-grained alignment. We present SATtxt, a VLFM that operates with RGB inputs at inference while retaining spectral cues learned during training and producing rich cross-modal representations. Our framework comprises two stages. First, Spectral Representation Distillation transfers spectral priors from a frozen multi-spectral teacher to an RGB student via a lightweight projector. Second, Spectrally Grounded Alignment with Instruction-Augmented LLMs bridges the distilled visual space and an expressive LLM embedding space. Across satellite benchmarks, SATtxt improves zero-shot classification on average by 4.2%, retrieval by 5.9%, linear probing by 2.7%, and open-vocabulary segmentation by 2.8% over baselines, showing an efficient path toward spectrum-aware vision-language learning for Earth observation. Project page: https://ikhado.github.io/sattxt/

Poster
MuViT: Multi-Resolution Vision Transformers for Learning Across Scales in Microscopy

Albert Dominguez Mantes, Gioele La Manno, Martin Weigert

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Modern microscopy routinely produces gigapixel images that contain structures across multiple spatial scales, from fine cellular morphology to broader tissue organization. Many analysis tasks require combining these scales, yet most vision models operate at a single resolution or derive multi-scale features from one view, limiting their ability to exploit the inherently multi-resolution nature of microscopy data. We introduce MuViT, a transformer architecture built to fuse true multi-resolution observations from the same underlying image. MuViT embeds all patches into a shared world-coordinate system and extends rotary positional embeddings to these coordinates, enabling attention to integrate large-scale context with high-resolution detail within a single encoder. Across synthetic benchmarks, kidney histopathology, and high-resolution mouse-brain microscopy, MuViT delivers consistent improvements over strong ViT and CNN baselines. Multi-resolution MAE pretraining further produces scale-consistent representations that enhance downstream tasks. These results demonstrate that explicit world-coordinate modelling provides a simple yet powerful mechanism for leveraging multi-resolution information in large-scale microscopy analysis. Code is available at github.com/weigertlab/muvit.

Poster
Stay in your Lane: Role Specific Queries with Overlap Suppression Loss for Dense Video Captioning

Seung Hyup Baek, Jimin Lee, Hyeongkeun Lee, Jae Won Cho

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Dense Video Captioning (DVC) is a challenging multimodal task that involves temporally localizing multiple events within a video and describing them with natural language. While query-based frameworks enable the simultaneous, end-to-end processing of localization and captioning, their reliance on shared queries often leads to significant multi-task interference between the two tasks, as well as temporal redundancy in localization. In this paper, we propose utilizing role-specific queries that separate localization and captioning into independent components, allowing each to exclusively learn its role. We then employ contrastive alignment to enforce semantic consistency between the corresponding outputs, ensuring coherent behavior across the separated queries. Furthermore, we design a novel suppression mechanism in which mutual temporal overlaps across queries are penalized to tackle temporal redundancy, supervising the model to learn distinct, non-overlapping event regions for more precise localization. Additionally, we introduce a lightweight module that captures core event concepts to further enhance semantic richness in captions through concept-level representations. We demonstrate the effectiveness of our method through extensive experiments on major DVC benchmarks YouCook2 and ActivityNet Captions.

Poster
PRISM: Learning a Shared Primitive Space for Transferable Skeleton Action Representation

Di Yang, Yaohui Wang, Shuai Shao, Francois Bremond, Jiangtao Wang

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Real-world human action understanding remains challenging due to long-tailed label distributions, compositional motion patterns, and viewpoint variations. Existing skeleton-based methods often lack a structured and transferable representation of motion, and task-specific models for generation, classification, and detection are usually trained independently, resulting in fragmented pipelines and limited cross-task generalization. We present PRISM, a PRImitive-centric Skeleton Modeling framework that learns a shared motion representation from a motion generation objective and transfers it to perception tasks. PRISM represents each action sequence as a trajectory in a primitive coefficient space, which captures how a set of learned atomic motion primitives contribute to the observed motion. A structured decomposition module learns this representation in a physically grounded and view-invariant manner via motion generation. Instead of enforcing joint or unified training across tasks, PRISM provides a single primitive-centric representation that can be sequentially transferred to downstream classification and frame-wise detection through lightweight task heads. This representation introduces structure, compositionality, and improved generalization across distinct supervisions. PRISM consistently improves performance on long-tailed and multi-label datasets and enables interpretable reasoning over compositional and rare actions. Extensive experimental results show that the structured primitive space serves as a transferable and robust foundation for diverse action understanding tasks in real-world datasets.

Poster
EfficientMonoHair: Fast Strand-Level Reconstruction from Monocular Video via Multi-View Direction Fusion

Da Li, Dominik Engel, Deng Luo, Ivan Viola

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Strand-level hair geometry reconstruction is a fundamental problem in virtual human modeling and the digitization of hairstyles. However, existing methods still suffer from a significant trade-off between accuracy and efficiency. Implicit neural representations can capture the global hair shape but often fail to preserve fine-grained strand details, while explicit optimization-based approaches achieve high-fidelity reconstructions at the cost of heavy computation and poor scalability. To address this issue, we propose EfficientMonoHair, a fast and accurate framework that combines the implicit neural network with multi-view geometric fusion for strand-level reconstruction from monocular video. Our method introduces a fusion-patch-based multi-view optimization that reduces the number of optimization iterations for point cloud direction, as well as a novel parallel hair-growing strategy that relaxes voxel occupancy constraints, allowing large-scale strand tracing to remain stable and robust even under inaccurate or noisy orientation fields. Extensive experiments on representative real-world hairstyles demonstrate that our method can robustly reconstruct high-fidelity strand geometries with accuracy. On synthetic benchmarks, our method achieves reconstruction quality comparable to state-of-the-art methods, while improving runtime efficiency by nearly an order of magnitude.

Poster
TempR1: Improving Temporal Understanding of MLLMs via Temporal-Aware Multi-Task Reinforcement Learning

Tao Wu, Li Yang, Gen Zhan, Yabin ZHANG, Yiting Liao, Junlin Li, Deliang Fu, Li Zhang, Limin Wang

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Enhancing temporal understanding of MLLMs is essential for long-form video analysis, supporting tasks such as temporal localization and time-sensitive question answering. While reinforcement learning (RL) has been explored for temporal reasoning, existing approaches are often limited to specific tasks or datasets, hindering generalization across diverse temporal scenarios. To address this, we present TempR1, an RL-based method that strengthens MLLMs' temporal comprehension through multi-task training. We construct a multi-task corpus covering diverse temporal structures and build upon the Group Relative Policy Optimization (GRPO) algorithm for stable cross-task optimization. Temporal tasks are categorized into three interval-instance correspondence types, with tailored localization rewards designed for each. This design enables TempR1 to capture fine-grained temporal dependencies and adapt to different temporal patterns. Experiments show that TempR1 achieves state-of-the-art performance on multiple benchmarks. Joint optimization across complementary tasks further produces strong synergy, improving both generalization and single-task performance, thereby providing a scalable paradigm for temporal reasoning in MLLMs.

Poster
CineBrain: A Large-Scale Multi-Modal Audiovisual Brain Dataset for Brain-Conditioned Video Generation

Jianxiong Gao, Yichang Liu, Baofeng Yang, Jianfeng Feng, Yanwei Fu

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Most research decoding brain signals into images, often using them as priors for generative models, has focused only on visual content. This overlooks the brain's natural ability to integrate auditory and visual information, for instance, sound strongly influences how we perceive visual scenes. To investigate this, we propose a new task of reconstructing continuous video stimuli from multimodal brain signals recorded during audiovisual stimulation. To enable this, we introduce CineBrain, the first large-scale dataset that synchronizes fMRI and EEG during audiovisual viewing, featuring six hours of The Big Bang Theory episodes for cross-modal alignment. We also conduct the first systematic exploration of combining fMRI and EEG for video reconstruction and present CineSync, a framework for reconstructing dynamic video using a Multi-Modal Fusion Encoder and a Neural Latent Decoder. CineSync achieves state-of-the-art performance in dynamic reconstruction, leveraging the complementary strengths of fMRI and EEG to improve visual fidelity. Our analysis shows that auditory cortical activations enhance decoding accuracy, highlighting the role of auditory input in visual perception. Project Page: https://jianxgao.github.io/CineBrain.

Oral
Predicting Spatial Transcriptomics from Histology Images via High-Order Multi-Cell Interaction Modeling

Youhan Sun, Jiahua Rao, Kangrui Du, Jiancong Xie, Yuedong Yang

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Spatial transcriptomics (ST) links gene expression to tissue architecture and enables predicting spatial expression from H&E-stained whole-slide images (WSIs). However, existing spot- or slide-level predictors focus on single-spot features or pairwise relations, failing to capture high-order, many-to-many cross-cell interactions. As a result, they miss synergistic and antagonistic effects among multiple neighboring cells. Here, we introduce MCToGene, a scalable and accurate framework that explicitly models multi-cell interactions via many-body attention with hierarchical coupling to predict spatial gene expression. MCToGene employs a many-body attention module to encode high-order, many-to-many cross-cell dependencies, enabling context-aware microenvironment modeling. To mitigate the combinatorial burden of many-body modeling, we design a hierarchical interaction module that couples pairwise and many-body representations for feature aggregation and prediction, preserving many-body expressiveness while controlling computation and memory. On HEST-1k and STImage-1K4M, MCToGene surpasses state-of-the-art baselines with 7.85% relative improvement. Ablations confirm that explicit high-order, many-to-many modeling drives these gains, and visualizations demonstrate that multi-cell interactions are essential for biologically coherent spatial predictions.

Poster