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arXiv

Representation and Invariance in Reinforcement Learning

Samuel Alexander, Arthur Paul Pedersen

Researchers have formalized reinforcement learning (RL) in different ways. If an agent in one RL framework is to run within another RL framework's environments, the agent must first be converted, or mapped, into that other framework. In this paper, we lay foundations for studying relative-intelligence-preserving mappability between RL frameworks. We introduce a criterion which is sufficient for relative intelligence to be preserved according to one particular method of measuring intelligence. We show that this criterion cannot be met when mapping between certain deterministic and stochastic RL frameworks, suggesting inherent fundamental differences between these different versions of RL.

arXiv

Spiking Local Interaction and Adaptive Complementary Fusion for Spiking Transformer

Dongcheng Zhao, sicheng shen, Zhenyu Yang, Zhiyuan Li, Jinyan Yu, Yongjian Wang, Tiechui Yao, Wenli Zhang, Tielin Zhang

Spiking Transformers model token interactions primarily through spiking self-attention (SSA). However, binary query and key representations map continuous similarities to sparse and discrete relation responses, which may suppress weak relations and limit the propagation of local spatial context. To address this limitation, we introduce Spiking Local Interaction (SLI) and Adaptive Complementary Fusion (ACF). SLI establishes an attention-independent pathway for direct information exchange among neighboring spiking tokens using lightweight depthwise--pointwise transformations. ACF integrates SSA and SLI through layer-specific, channel-wise coefficients that adaptively balance their contributions at different network depths. The proposed design preserves the original attention formulation and can be incorporated into different Spiking Transformer architectures with modest parameter overhead. Experiments on ImageNet-1K, CIFAR-10, CIFAR-100, CIFAR10-DVS, and ADE20K show consistent improvements across image classification, event-based recognition, and semantic segmentation. In particular, QKFormer with SLI and ACF achieves $84.37\%$ Top-1 accuracy on ImageNet-1K and $37.5\%$ mIoU on ADE20K, where the segmentation model is trained without ImageNet pretraining. Ablation studies and qualitative analyses further indicate that SSA and SLI capture complementary interaction patterns and that learnable fusion consistently outperforms fixed weighting.

arXiv

SpotlessGS: Relightable 3D Gaussian Splatting under Dynamic Illumination for Robotic Perception

Liang Hong, Jiaxin Wei, Simon Schaefer, Stefan Leutenegger, Jaehyung Jung

Robots operating in dark or poorly lit environments rely on onboard lights, which often produce uneven illumination that degrades downstream perception tasks. Prior approaches based on 2D image enhancement lack reliable supervision and fail to preserve multi-view geometric consistency. To address these limitations, we extend Dark Gaussian Splatting (DarkGS) toward a more accurate and flexible relightable 3D reconstruction framework. First, we eliminate the need for explicit light parameter calibration by jointly optimizing lighting parameters within the Gaussian Splatting framework. Second, we introduce a low-frequency illumination model based on spherical harmonics (SH) to capture spatially varying residual and ambient lighting effects. Third, we incorporate an MLP-based Bidirectional Reflectance Distribution Function (BRDF) to model non-Lambertian reflectance. Experiments on synthetic and real-world datasets demonstrate that our method effectively mitigates illumination artifacts while improving rendering quality and quantitative performance over prior approaches. We further validate its benefits for robotic perception through a downstream task.

arXiv

Hardware-in-the-Loop Phase-Aware CNN for Real-Time 5G Channel Estimation

Javad Zolfaghari-Bengar, Rakibul Rony, Elisa Gomez-de-Lope, Alejandro Villena-Rodriguez, Abhinav Mahadevan, Nicolas Kourtellis

This demo presents real-time AI-based uplink channel-estimation inference using data collected from a hardware-in-the-loop 5G platform. The data-collection setup integrates commercial RF signal generation, programmable channel emulation, an O-RAN Radio Unit, DU emulation, and a lightweight phase-aware convolutional neural network (CNN) that estimates the channel response directly from received DMRS signals. Unlike simulation-only evaluations, the hardware-derived dataset exposes the estimator to practical RF and system-level impairments, including calibration mismatches, synchronization imperfections, quantization effects, phase noise, and implementation-specific nonlinearities. During the demo, attendees will observe real-time CNN inference and channel reconstruction using captured hardware-generated DMRS observations and compare the proposed CNN against Least Squares (LS) and frequency-domain LMMSE baselines. The objective is to showcase a practical AI-native physical-layer inference pipeline that combines hardware-derived 5G data with real-time neural channel estimation for future 5G-Advanced and 6G systems.

arXiv

PE-CSNet: An equivariant network architecture with learnable patch-based sparse representation

Kai Li, Haitao Long, Bo Zhang, Haiwen Zhang, Zhi Zhou

Compressive sensing (CS) enables accurate signal reconstruction from sparse measurements and is widely applied in medical imaging, remote sensing, and image compression. However, designing an effective, task-specific sparse transform and the corresponding optimization procedure for high-quality CS remains challenging. This process typically requires expert domain knowledge and laborious parameter tuning. To address this issue, we present a Patch-based Equivariant deep unrolling architecture, termed PE-CSNet, for accurate CS recovery. While traditional CS methods generally use predefined patch-based transform sparsity, we generalize this idea by incorporating learnable transform sparsity that adapts to the specific CS task through an optimization-driven process. Specifically, we first establish a generalized patch-based CS model, which we solve via a block coordinate descent (BCD) algorithm. The BCD solver is then unrolled into a deep neural network, where all parameters of both the CS model and solver are learned through end-to-end training. To improve data efficiency, we introduce a stochastic equivariant training strategy that exploits the patch-wise structure of the network, enabling PE-CSNet to learn effectively even from limited data. We further provide a simpler, parameter-shared version of PE-CSNet and briefly discuss its convergence as an iterative solver. For practical applications, the network uses stage-specific (non-shared) parameters to enhance its expressive power and thereby improve its performance. On the tasks of CS magnetic resonance imaging (CS-MRI) and CS coded diffraction patterns (CS-CDP), PE-CSNet achieves state-of-the-art accuracy with fast computational speed, outperforming traditional methods and existing deep unrolling methods.

arXiv

Equilibrium Forcing: Adaptive Video Generation Without Noise Conditioning

Hansen Jin Lillemark, Alex Rojas, Zachary Novack, Runqian Wang, Yilun Du, Yian Ma, Taylor Berg-Kirkpatrick, Rose Yu

Standard autoregressive video generation algorithms based on Diffusion and Flow Matching rely on rigid training objectives and static sampling schedules, limiting inference procedures from adapting to the data. We introduce Equilibrium Forcing (EqF), a simplified framework for video denoising generative models without noise level conditioning. EqF pioneers modular training- and inference-time designs for noise-unconditional generation that decouple learning the denoising field from sampling. This flexibility allows for inference-time algorithms that operate in a closed loop by adapting to feedback from the sample, improving video quality and consistency on challenging autoregressive video generation benchmarks. Extensive analysis elucidates exactly how removing the noise level conditioning enables EqF's data-dependent inference properties to surpass the performance of standard noise level-conditional denoising video methods.

arXiv

Language-Structured Relational Q-Learning for Threat-Aware Control in Safety-Critical Driving

Aditya Humnabadkar, Huaizhong Zhang, Ardhendu Behera

Natural-language-based scenario generation offers an intuitive means of describing rare and complex driving interactions, yet it is still uncertain whether training with language-structured data leads to truly adaptive control policies. We propose Language-Structured Relational Q-Learning, instantiated through an Ego-Centric Relational Q-Network (ERQ-Net), which jointly learns inter-vehicle relevance and action values from dynamic traffic graphs. Language descriptions define surrounding-vehicle behaviours during training, while prompts and semantic actor roles are hidden from the policy. ERQ-Net must therefore infer threat relevance solely from observable kinematics and interactions. Across 2,500 safety-critical scenarios, language-structured training improves test success from 49-52% to 55-58% and increases adversary-focused attention from 1.2x to 2.1x, demonstrating emergent threat awareness. However, this representational gain does not consistently translate into adaptive control: trained policies perform similarly to the best constant action, while a portfolio of simple policies solves 76% of scenarios. We formalise this discrepancy as a recognition-control gap and show that reward reweighting and margin shaping do not eliminate the resulting policy collapse. Evaluations of realism, criticality, semantic accuracy, and transfer of state-interface representations to CARLA further highlight both the strengths and the constraints of language-structured relational policy learning in safety-critical driving scenarios.

arXiv

Test-Time Hallucination Control in Large Vision-Language Models

Mehran Tamjidi, Hamidreza Dastmalchi, Ali Cheraghian, Mohammadreza Alimoradijazi, Aijun An, Hossein Rahmani

Object Hallucination in large vision-language models (LVLMs), where models generate non-factual content about input images, remains a critical barrier to their reliability in real-world applications. Existing mitigation strategies can be categorized into training-based and training-free methods. Training-based methods often achieve strong performance but are costly, requiring extensive computational resources, large-scale data, and time-consuming fine-tuning. Training-free approaches are particularly appealing due to their efficiency. However, existing training-free methods either require multiple decoding rounds, which adds computational overhead, or modify internal states in a model-specific way that risks degrading pretrained knowledge. We propose Test-Time Hallucination Mitigation (TTH) method, a novel training-free method that addresses both limitations. TTH introduces a token-validator module, implemented as a zero-shot Multi-Modal Classifier (MMC), to generate auxiliary logits grounded in the input image. These logits are fused with the original LVLM outputs at the token level for object tokens selected from a candidate pool. An entropy-based weighting scheme is then applied to enable robust and accurate predictions. Extensive experiments across multiple LVLM families and diverse benchmarks demonstrate that TTH consistently improves accuracy and robustness, underscoring its generalizability and practical effectiveness. Code is released at https://github.com/Mehran-TAM/TTH

arXiv

Gaussian Meta-Space Augmentation for Stacking Ensembles in Multimodal IPMN Risk Stratification

Max A. Nelson, Eminenur Sen Tasci, Zhixiang Wang, Zongwei Zhou, Halil Ertugrul Aktas, Andrea M. Bejar, Elif Keles, Ziliang Hong, Sıtkı Safa Taflan, Muhammed Enes Tasci, Frank H. Miller, Michael B. Wallace, Rajesh N. Keswani, Gorkem Durak, Ulas Bagci

Pancreatic cancer is among the most lethal malignancies; risk stratification of intraductal papillary mucinous neoplasms (IPMNs) offers a crucial opportunity for early intervention but typically requires invasive tissue biopsy. Dominant vision-based approaches, including radiomics and deep learning, provide promising but initially separate discrimination opportunities. Similarly, multisequence MRI (T1W/T2W) and anatomically decomposed (head, body and tail) analysis of the pancreas provide additional and potentially complementary signals. Effective fusion of this information is crucial in ordinal IPMN dysplasia risk prediction and can be accomplished via a meticulously regularized and calibrated ensemble stacking combiner. We present cUPMI, a class-conditional Gaussian augmentation of a combiner's log-probability meta-features, and test it on various prediction paradigms. In our multi-center analysis, we find cUPMI adds limited value to properly regularized L2-logistic binary classification stacks, but consistently regularizes higher-capacity tree combiners in the binary and radiomics-only setting (RF +0.015 and XGBoost +0.024 binary AUC, positive in all seeds). Its cleanest ordinal benefit appears for XGBoost on an 8-stream radiomics task (3-class no < low < high, +0.022 QWK in all seeds). Separately, fold-locked fusion of radiomics and 2.5D CNN streams yields the strongest overall model, an RF stack reaching QWK 0.595 (95% CI [0.54, 0.64]) and binary AUC 0.839, surpassing radiomics, 2.5D ResNet, and 3D DenseNet-121 baselines.

arXiv

Multi-Agent Target-Existence Verification and Learned Mask Geometry Refinement: Winning Report of the MeViS-Text Track at the 8th LSVOS Challenge 2026

Jungyoon Lee, Gyuil Lim, Doeon Kim, Seong-heum Kim

We present the first-place solution to the MeViS-Text track of the 8th Large-scale Video Object Segmentation (LSVOS) Challenge 2026: referring video object segmentation guided by written motion expressions, including deceptive no-target expressions that match no object in the video and must yield empty masks in every frame. Our pipeline, SSUPER, resolves each expression into a visual concept, generates full-video candidate masklets with SAM~3.1, and selects target IDs. At every reasoning stage, three heterogeneous multimodal large language models independently execute the same stage-specific prompt before a single synthesis pass commits one schema-validated verdict. Although this system rejects every no-target expression in validation, the leaderboard reveals that a substantial share of test no-target cases still slips through. The reason is that hard negatives name a plausible object and fail only under the complete temporal predicate, so when selection and existence are decided together, a category-plausible masklet anchors the verdict. Hence, we decouple existence verification into an independent multi-agent audit of the full predicate (category, count, action, trajectory, event order, and semantic role) that distinguishes absence from temporary invisibility, discounts apparent motion caused by camera movement, and requires contradicting evidence rather than mere uncertainty for a no-target verdict. Without any new segmentation call, this audit recovers most of the residual no-target errors. A training-data-only StyleRefiner then aligns mask geometry with the annotation style of MeViSv2 while preserving every presence decision by construction, showing that once the semantics are fixed, part of the remaining error is stylistic rather than semantic. The complete system reaches a Final score of 0.9081339614 on the official challenge leaderboard.

arXiv

TangPoetryBench: A Multi-Dimensional Benchmark and Rubric-Conditioned Evaluator for Poetry-to-Image Generation

Haoqi Hu, Tongji Luo, Li Zhang, Boning Zhou

Text-to-image (T2I) models are increasingly asked to illustrate literary and cultural content, yet we cannot measure how well an image renders the meaning of a poem. The task is many-sided: a good illustration must be visually sound, faithful to the poem's imagery and scene, culturally and stylistically apt, free of spurious text, and true to its emotion, and its deepest requirements, imagery and especially implicit emotion, are never stated in the words. Existing metrics (CLIPScore, BLIPScore, VQAScore) reward literal text-image correspondence and so cannot tell whether an illustration succeeds, let alone why, or even separate the best model from the worst. We introduce TangPoetryBench, a multi-dimensional benchmark of 1,280 images (320 classical Chinese Tang poems x 4 state-of-the-art T2I models) with quality-controlled human annotations across ten dimensions. Analyzing this data, we reveal the shared and model-specific strengths and weaknesses of current T2I models, including their ability to evoke a poem's implicit emotion. We further introduce PoemAutoEvaluator (PAE), an open, rubric-conditioned evaluator that reaches parity with a strong proprietary judge (Claude), generalizes to an unseen generator and a second poetic tradition (Song Ci), and lets the benchmark scale to new images without fresh human annotation. We release the benchmark, annotations, and evaluator.

arXiv

VLMs Win a Systematic Evaluation of Underwater Image Reconstruction

Sara Aghajanzadeh, Yingxue Wang, Ieva Bagdonaviciute, David Forsyth

Underwater image restoration consists of recovering an image which looks like there is no water present. To date, evaluation has not been systematic. This paper describes a systematic evaluation pipeline for underwater reconstruction, which can be used to assess a method for accuracy; consistency of reconstruction over camera moves; and the effect of water parameters. We use this pipeline to evaluate a range of current procedures, from models constructed using explicit but approximate physical models of scattering to Vision-Language Models (VLMs which are not currently trained with explicit physical models). Overall, VLMs wholly and significantly outperform physically based models in our evaluation, likely because of the importance of a strong image prior. Results on images of real underwater scenes strongly confirm the evaluation.

arXiv

Click2Poly: A VLM for vector mapping buildings and walls

Nicolas Girard, Jawher Ben Abdallah, Arno Gobbin, Liuyun Duan, Sacha Lepretre

Accurate vector mapping of buildings and walls is critical for geospatial applications but remains a labor-intensive process. While recent deep learning methods have improved automatic extraction, in order to meet cartographic standards they always require a human to perform quality control and fix complex cases in the extraction. We present Click2Poly, a human-in-the-loop AI assistant designed to speed up this manual step. Extending the Florence-2 Vision Language Model (VLM), Click2Poly responds to user clicks by editing the building or wall vector layer directly. Implemented as a QGIS plugin, Click2Poly speeds up the manual editing of building and wall vector layers in a real-world production environment.

arXiv

Analysis of Federated Aggregation under Model Poisoning and Backdoor Attacks: A Reconstructed Cross-Dataset and Cross-Architecture Benchmark

Soumya Mazumdar, Vineet Kumar Rakesh, Tapas Samanta

Robust comparisons of federated aggregation methods require joint consideration of predictive performance, threat definitions, metric semantics, and execution provenance. A 500-cell seed-1 evaluation matrix was reconstructed across five aggregation methods, five datasets, five architectures, and four recorded conditions: clean, sign-flipping, Gaussian, and BadNets. Successful execution logs were identified for 454 original runs and 36 repaired or rerun executions, whereas 10 clean SVHN cells were supported by summary-only provenance. Trimmed Mean achieved the highest clean macro-mean accuracy (76.02%) and the lowest mean within-task rank (1.70). Krum attained the highest recorded accuracy under both sign-flipping and Gaussian configurations. These relative rankings remained unchanged when analysis was restricted to 21 task pairs for which original successful logs were available for every method-condition combination. Audit of the supplied BadNets metric implementation established that every test input is triggered prior to target-label counting; consequently, the retained metric represents Triggered Target-Label Rate (TTLR) rather than a conventional target-excluding attack success rate. An audit of the supplied FedPARETO scaffold further identified a pathway in which predictive summaries may characterize an uncorrupted local model while the aggregation weight is applied to a separately corrupted update, introducing a potential discrepancy between reported predictive outcomes and the updates used for aggregation. The canonical matrix contains a single identified seed for each cell, and exact attack and configuration lineage is incomplete. Accordingly, the findings should be interpreted as descriptive comparisons within the recorded configurations and not as statistical estimates or universal claims regarding robustness.

arXiv

COGENT: Counterfactual Gaussian Explanations for Volumetric Medical Images

Dorian Rząsa, Bartosz Zabdyr, Krzysztof Piekarz, Jakub Grzywaczewski, Bartlomiej Sobieski, Przemyslaw Biecek, Żaneta Świderska-Chadaj, Olga Śliwicka, Przemysław Spurek, Joanna Świebocka-Więk

Explainability is essential for deploying deep learning models in high-stakes medical applications. Existing explainability methods for volumetric imaging predominantly operate in voxel space, overlooking the structured representations introduced by recent advances in 3D scene modeling. We present COGENT (Counterfactual Gaussian Explanations), a framework that generates counterfactual explanations directly in the parameter space of Gaussian-based volumetric representations. Built upon MedGS and the Sybil lung cancer risk prediction model, COGENT optimizes selected Gaussian primitives through a differentiable rendering pipeline, enabling gradients from the downstream predictor to identify representation components that most influence model decisions. Unlike conventional pixel- or voxel-level attribution methods, our approach formulates explainability as a counterfactual optimization problem over an explicit 3D scene representation, producing sparse and spatially localized explanations while preserving anatomical consistency. We evaluate COGENT on lung CT scans using quantitative comparisons with existing explainability methods together with qualitative analysis by medical experts. The results demonstrate that representation-space counterfactual optimization provides clinically meaningful explanations while offering a new perspective on interpreting volumetric deep learning models.

arXiv

Gaze Target Estimation Anywhere with Concepts

Xu Cao, Houze Yang, Vipin Gunda, Zhongyi Zhou, Tianyu Xu, Adarsh Kowdle, Inki Kim, James M. Rehg

Estimating human gaze targets from images in-the-wild is an important and formidable task. Existing approaches primarily employ brittle, multi-stage pipelines that require explicit inputs, like head bounding boxes and human pose, in order to identify the subject of gaze analysis. As a result, detection errors can cascade and lead to failure. Moreover, these prior works lack the flexibility of specifying the gaze analysis task via natural language prompting, an approach which has been shown to have significant benefits in convenience and scalability for other image analysis tasks. To overcome these limitations, we introduce the Promptable Gaze Target Estimation (PGE) task, a new end-to-end, concept-driven paradigm for gaze analysis. PGE conditions gaze prediction on flexible user text or visual prompts (e.g., "the boy in the red shirt" or "person in point [0.52, 0.48]") to identify a specific subject for gaze analysis. This approach integrates subject localization with gaze estimation, and eliminates the rigid dependency on intermediate analysis stages. We develop a scalable data engine to generate Gaze-Co (Gaze Estimation with Concepts), a dataset and benchmark of 120K high-quality, prompt-annotated image pairs. We also propose GazeAnywhere, the first model designed for PGE. GazeAnywhere uses a transformer-based detector to fuse features from frozen encoders and simultaneously solves subject localization, in/out-of-frame presence, and gaze target heatmap estimation. GazeAnywhere achieves state-of-the-art performance on multiple PGE benchmarks, setting a strong baseline for this new problem even on a difficult out-of-domain, real-world clinical dataset. GazeAnywhere is open-sourced in github.com/IrohXu/GazeAnywhere.

arXiv

Can Frontier LLMs Match Natively Multimodal Embeddings? A Comparison on Hard-Negative Text-to-Image Retrieval

Archan Dutta, Vyanktesh Kanungo

Multimodal retrieval and classification across different types of media, spanning text, images,video and audio, has traditionally relied on dual-encoder models that align visual and textual representations through contrastive learning. The March 2026 release of Gemini Embedding 2, Google's first natively multimodal embedding model to map text, images, video, audio, and documents into a single shared space, raises competition among multimodal retrieval systems. Simultaneously, frontier Large language models (LLMs) have also demonstrated strong visual understanding, raising the question of whether they can serve as effective zero-shot rankers. Our study provides the first direct comparison of native multimodal embeddings against LLM-based visual ranking on Flickr30k. We observe that GPT-4.1 and Claude Sonnet 4.6 perform on par with Gemini Embedding 2. Additionally, once embeddings are precomputed, multimodal embeddings are better suited for low-latency applications.

arXiv

Dual-Domain Cross-Modal Decoding for Clinical Text-Guided Medical Image Segmentation

Md Maklachur Rahman, Tracy Hammond

Clinical text can narrow down what to segment, but recent text-guided designs emphasize spatial alignment while overlooking frequency content that governs texture and boundaries. We propose Dual-Domain Cross-Modal Decoding (DD-CMD) for clinical text-guided pulmonary infection segmentation, integrating two complementary forms of language guidance during decoding. In the spatial domain, Text-Guided Spatial Cross-Attention (TGSA) aligns multi-scale visual tokens with text semantics and updates features through gated residual fusion. In the frequency domain, Spectral-Text Adaptive Modulation (STAM) applies a 2D DCT to compute learnable band-energy statistics and predicts text-conditioned FiLM parameters to recalibrate decoder channels for frequency-aware decoding. DD-CMD embeds TGSA and STAM into a coarse-to-fine decoder (7x7 to 56x56) and restores full-resolution masks using a lightweight two-stage refinement module. Experiments on QaTa-COV19 and MosMedData+ show that DD-CMD achieves 91.46% Dice / 84.26% mIoU and 81.95% Dice / 69.42% mIoU, respectively, with average gains of +1.96 Dice and +2.67 mIoU over the strongest prior baselines. Code: https://github.com/maklachur/DD-CMD.

arXiv

Qwen-MusicAVQA-7B: A Multimodal Model for Music Audio-Visual QA

Maryam Dehdashti

A common approach to adding audio to a vision-language model is to train or adapt a large omni-modal system. We show that a lightweight alternative can be highly effective for music audio-visual question answering (AVQA). Qwen-MusicAVQA-7B connects a frozen Whisper encoder to Qwen2-VL-7B-Instruct through learned linear projections. The same frozen encoder processes both the video's music track and a TTS-spoken question through separate projectors, while the language model fuses visual frames, music, and question audio through pretrained self-attention, with no task-specific fusion network. On MUSIC-AVQA, our system reaches 96.0% +/- 3.9% accuracy across three independent training seeds on the 7,402-question available-video test subset. Our central finding is that downstream accuracy tracks how much fine-grained local temporal information the audio representation preserves. In a matched 32-token comparison, a stride-pooled Whisper frame sequence outperforms a globally pooled PANNs representation expanded to the same budget by 26 percentage points, even though PANNs sees at least as much audio and uses a far larger projector. The effect is not simply sequence versus vector: within Whisper alone, reducing temporal resolution at a fixed token budget costs a comparable amount. Under matched data and inputs, fine-tuned Qwen2.5-Omni-7B reaches 80.9%, against 95.9% for our 30 s variant; because the systems differ in backbone and adaptation, this is a system-level comparison. Accuracy remains high on sampled head and tail splits of the rephrased MUSIC-AVQA-R benchmark (96.5% and 95.6%). Because both encoders stay frozen and the music features are cached, the entire adaptation is cheap to train: the complete two-stage AVQA run takes approximately 5 hours on a single A100 80GB, and every run reported here fits on that one GPU.

arXiv

Clinical Feasibility of Low-Magnification Fluorescence Imaging for Breast Cancer Margin Detection Using Texture Analysis and Deep Learning

Pouya Afshin, Tianling Niu, Tongtong Lu, David Helminiak, Julie Jorns, Mollie Patton, Tina Yen, Donghye Ye, Bing Yu

High-resolution images of unprocessed surgical breast tissue can be obtained using microscopy with ultraviolet surface excitation (MUSE). This technique is considered a promising method for checking surgical margins during breast cancer surgery. In this study, MUSE images at 4x and 10x magnifications were compared using patch-level classification methods. Texture analysis (TA) based on local binary patterns (LBP) and deep learning (DL) with a base Vision Transformer (ViT) model were used. Both methods achieved similar performance at both magnifications. Using DL method, both 4x and 10x magnifications achieved 96.30% sensitivity, 100% specificity and 98.18% accuracy. Using TA method, 4x achieved better specificity (100% vs 93.33%) and 10x yielded higher sensitivity (100% vs 93.33%), but both had the same accuracy (96.67%). No clear improvement in performance was observed with 10x magnification. These results show that 4x imaging achieves the same diagnostic accuracy as 10x imaging. At the same time, 4x offers a larger field of view and faster image capture. Therefore, lower magnification can be effectively used in MUSE systems for accurate and efficient intraoperative margin assessment.

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