CVPR 2025 Papers

Foundational models such as the Segment Anything Model (SAM) are gaining traction in medical imaging segmentation, supporting multiple downstream tasks. However, such models are supervised in nature, still relying on large annotated datasets or prompts supplied by experts. Conventional techniques such as active learning to alleviate such limitations are limited in scope and still necessitate continuous human involvement and complex domain knowledge for label refinement or establishing reward ground truth. To address these challenges, we propose an enhanced Segment Anything Model (SAM) framework that utilizes annotation-efficient prompts generated in a fully unsupervised fashion, while still capturing essential semantic, location, and shape information through contrastive language-image pretraining and visual question answering. We adopt the direct preference optimization technique to design an optimal policy that enables the model to generate high-fidelity segmentations with simple ratings or rankings provided by a virtual annotator simulating the human annotation process. State-of-the-art performance of our framework in tasks such as lung segmentation, breast tumor segmentation, and organ segmentation across various modalities, including X-ray, ultrasound, and abdominal CT, justifies its effectiveness in low-annotation data scenarios.

Recent 3D deep networks such as SwinUNETR, SwinUNETRv2, and 3D UX-Net have shown promising performance by leveraging self-attention and large-kernel convolutions to capture the volumetric context. However, their substantial computational requirements limit their use in real-time and resource-constrained environments. The high #FLOPs and #Params in these networks stem largely from complex decoder designs with high-resolution layers and excessive channel counts. In this paper, we propose EffiDec3D, an optimized 3D decoder that employs a channel reduction strategy across all decoder stages, which sets the number of channels to the minimum needed for accurate feature representation. Additionally, EffiDec3D removes the high-resolution layers when their contribution to segmentation quality is minimal. Our optimized EffiDec3D decoder achieves a 96.4% reduction in #Params and a 93.0% reduction in #FLOPs compared to the decoder of original 3D UX-Net. Similarly, for SwinUNETR and SwinUNETRv2 (which share an identical decoder), we observe reductions of 94.9% in #Params and 86.2% in #FLOPs. Our extensive experiments on 12 different medical imaging tasks confirm that EffiDec3D not only significantly reduces the computational demands, but also maintains a performance level comparable to original models, thus establishing a new standard for efficient 3D medical image segmentation. Our implementation is available at https://github.com/SLDGroup/EffiDec3D.

Semi-supervised learning in medical image segmentation leverages unlabeled data to reduce annotation burdens through consistency learning. However, current methods struggle with class imbalance and high uncertainty from pathology variations, leading to inaccurate segmentation in 3D medical images. To address these challenges, we present DyCON, a Dynamic Uncertainty-aware Consistency and Contrastive Learning framework that enhances the generalization of consistency methods with two complementary losses: Uncertainty-aware Consistency Loss (UnCL) and Focal Entropy-aware Contrastive Loss (FeCL). UnCL enforces global consistency by dynamically weighting the contribution of each voxel to the consistency loss based on its uncertainty, preserving high-uncertainty regions instead of filtering them out. Initially, UnCL prioritizes learning from uncertain voxels with lower penalties, encouraging the model to explore challenging regions. As training progress, the penalty shift towards confident voxels to refine predictions and ensure global consistency. Meanwhile, FeCL enhances local feature discrimination in imbalanced regions by introducing dual focal mechanisms and adaptive confidence adjustments into the contrastive principle. These mechanisms jointly prioritizes hard positives and negatives while focusing on uncertain sample pairs, effectively capturing subtle lesion variations under class imbalance. Extensive evaluations on four diverse medical image segmentation datasets (ISLES'22, BraTS'19, LA, Pancreas) show DyCON's superior performance against SOTA methods(\href https://dycon25.github.io/) Project Page: https://dycon25.github.io/ .

Achieving robust stereo 3D imaging under diverse illumination conditions is an important however challenging task, largely due to the limited dynamic ranges (DRs) of cameras, which are significantly smaller than real world DR. As a result, the accuracy of existing stereo depth estimation methods is often compromised by under- or over-exposed images.In this work, we introduce dual-exposure stereo for extended dynamic range 3D imaging. We develop automatic dual-exposure control method that adjusts the dual exposures, diverging them when the scene DR exceeds the camera DR, thereby providing information about broader DR. From the captured dual-exposure stereo images, we estimate depth by developing a motion-aware dual-exposure stereo depth network.To validate our proposed method, we develop a robot-vision system, collect real-world stereo video datasets, and generate a synthetic dataset. Our approach outperforms traditional exposure control and depth estimation methods.

Medical Visual Question Answering (Med-VQA) systems benefit the interpretation of medical images containing critical clinical information. However, the challenge of noisy labels and limited high-quality datasets remains underexplored. To address this, we establish the first benchmark for noisy labels in Med-VQA by simulating human mislabeling with semantically designed noise types. More importantly, we introduce the DiN framework, which leverages a diffusion model to handle noisy labels in Med-VQA. Unlike the dominant classification-based VQA approaches that directly predict answers, our Answer Diffuser (AD) module employs a coarse-to-fine process, refining answer candidates with a diffusion model for improved accuracy. The Answer Condition Generator (ACG) further enhances this process by generating task-specific conditional information via integrating answer embeddings with fused image-question features. To address label noise, our Noisy Label Refinement(NLR) module introduces a robust loss function and dynamic answer adjustment to further boost the performance of the AD module. Our DiN framework consistently outperforms existing methods across multiple benchmarks with varying noise levels.

Hyperspectral 3D imaging captures both depth maps and hyperspectral images, enabling comprehensive geometric and material analysis. Recent methods achieve high spectral and depth accuracy; however, they require long acquisition times--often over several minutes--or rely on large, expensive systems, restricting their use to static scenes. We present Dense Dispersed Structured Light (DDSL), an accurate hyperspectral 3D imaging method for dynamic scenes that utilizes stereo RGB cameras and an RGB projector equipped with an affordable diffraction grating film. We design spectrally multiplexed DDSL patterns that significantly reduce the number of required projector patterns, thereby accelerating acquisition speed. Additionally, we formulate an image formation model and a reconstruction method to estimate a hyperspectral image and depth map from captured stereo images. As the first practical and accurate hyperspectral 3D imaging method for dynamic scenes, we experimentally demonstrate that DDSL achieves a spectral resolution of 15.5 nm full width at half maximum (FWHM), 4 mm depth error, and 6.6 fps.

In the field of 3D medical imaging, accurately extracting and representing the blood vessels with curvilinear structures holds paramount importance for clinical diagnosis. Previous methods have commonly relied on discrete representation like mask, often resulting in local fractures or scattered fragments due to the inherent limitations of the per-pixel classification paradigm. In this work, we introduce DeformCL, a new continuous representation based on Deformable Centerlines, where centerline points act as nodes connected by edges that capture spatial relationships. Compared with previous representations, DeformCL offers three key advantages: natural connectivity, noise robustness, and interaction facility. We present a comprehensive training pipeline structured in a cascaded manner to fully exploit these favorable properties of DeformCL. Extensive experiments on four 3D vessel segmentation datasets demonstrate the effectiveness and superiority of our method. Furthermore, the visualization of curved planar reformation images validates the clinical significance of the proposed framework.

Thermal imaging is often compromised by dynamic, complex degradations caused by hardware limitations and unpredictable environmental factors. The scarcity of high-quality infrared data, coupled with the challenges of dynamic, intricate degradations, makes it difficult to recover details using existing methods. In this paper, we introduce thermal degradation simulation integrated into the training process via a mini-max optimization, by modeling these degraded factors as adversarial attacks on thermal images. The simulation is dynamic to maximize objective functions, thus capturing a broad spectrum of degraded data distributions. This approach enables training with limited data, thereby improving model performance. Additionally, we introduce a dual-interaction network that combines the benefits of spiking neural networks with scale transformation to capture degraded features with sharp spike signal intensities. This architecture ensures compact model parameters while preserving efficient feature representation. Extensive experiments demonstrate that our method not only achieves superior visual quality under diverse single and composited degradation, but also delivers a significant reduction in processing when trained on only fifty clear images, outperforming existing techniques in efficiency and accuracy. The source code will be available at https://github.com/LiuZhu-CV/DEAL.

Reconstructing complex structures from planar cross-sections is a challenging problem, with wide-reaching applications in medical imaging, manufacturing, and topography. Out-of-the-box point cloud reconstruction methods can often fail due to the data sparsity between slicing planes, while current bespoke methods struggle to reconstruct thin geometric structures and preserve topological continuity. This is important for medical applications where thin vessel structures are present in CT and MRI scans. This paper introduces CrossSDF, a novel approach for extracting a 3D signed distance field from 2D signed distances generated from planar contours. Our approach makes the training of neural SDFs contour-aware by using losses designed for the case where geometry is known within 2D slices. Our results demonstrate a significant improvement over existing methods, effectively reconstructing thin structures and producing accurate 3D models without the interpolation artifacts or over-smoothing of prior approaches.

The development of large-scale image-text pair datasets has significantly advanced self-supervised learning in Vision-Language Processing (VLP). However, directly applying general-domain architectures such as CLIP to medical data presents challenges, particularly in handling negations and addressing the inherent data imbalance of medical datasets. To address these issues, we propose a novel approach that integrates clinically-enhanced dynamic soft labels and medical graphical alignment, thereby improving clinical comprehension and improving the applicability of contrastive loss in medical contexts. Furthermore, we introduce negation-based hard negatives to deepen the model's understanding of the complexities of clinical language. Our approach is easily integrated into medical CLIP training pipeline and achieves state-of-the-art performance across multiple tasks, including zero-shot, fine-tuned classification and report retrieval. To comprehensively evaluate our model's capacity in understanding clinical language, we introduce CXR-Align, a benchmark uniquely designed to evaluate the understanding of negation and clinical information within chest X-ray (CXR) datasets. Experimental results demonstrate that our proposed methods are straightforward to implement and generalize effectively across contrastive learning frameworks, enhancing medical VLP capabilities and advancing clinical language understanding in medical imaging.

Semi-supervised polyp segmentation has made significant progress in recent years as a potential solution for computer-assisted treatment. Since depth images can provide extra information other than RGB images to help segment these problematic areas, depth-assisted polyp segmentation has gained much attention. However, the utilization of depth information is still worth studying. The existing RGB-D segmentation methods rely on depth data in the inference stage, limiting their clinical applications. To tackle this problem, we propose a semi-supervised polyp segmentation framework based on the mean teacher architecture. We establish an auxiliary student network with depth images as input in the training stage, and we propose a depth-guided cross-modal mutual learning strategy to promote the learning of complementary information between different student networks. Meanwhile, we use the high-confidence pseudo-labels generated by the auxiliary student network to guide the learning progress of the main student network from different perspectives. Our model does not need depth data in the inference phase. In addition, we introduce a depth-guided patch augmentation method to improve the model's learning performance in difficult regions of unlabeled polyp images. Experimental results show that our method achieves state-of-the-art performance under different label conditions on five polyp datasets. The code is available at https://github.com/pingchuan/RD-Net.

This study introduces a novel zero-shot scan-specific self-supervised reconstruction method for magnetic resonance imaging (MRI) to reduce scan times. Conventional supervised reconstruction methods require large amounts of fully-sampled reference data, which is often impractical to obtain and can lead to artifacts by overly emphasizing learned patterns. Existing zero-shot scan-specific methods have attempted to overcome this data dependency but show limited performance due to insufficient utilization of k-space information and constraints derived from MRI forward model. To address these limitations, we introduce a framework utilizing all acquired k-space measurements for both network inputs and training targets. While this framework suffers from training instability, we resolve these challenges through three key components: an Attention-guided K-space Selective Mechanism (AKSM) that provides indirect constraints for non-sampled k-space points, Iteration-wise K-space Masking (IKM) that enhances training stability, and a robust sensitivity map estimation model utilizing cross-channel constraint that performs effectively even at high reduction factors. Experimental results on the FastMRI knee and brain datasets with reduction factors of 4 and 8 demonstrate that the proposed method achieves superior reconstruction quality and faster convergence compared to existing zero-shot scan-specific methods, making it suitable for practical clinical applications. The implementation of our proposed method is publicly available at https://github.com/joojinho97/AeSPa.git.

Advances in medical imaging and deep learning have propelled progress in whole slide image (WSI) analysis, with multiple instance learning (MIL) showing promise for efficient and accurate diagnostics. However, conventional MIL models often lack adaptability to evolving datasets, as they rely on static training that cannot incorporate new information without extensive retraining. Applying continual learning (CL) to MIL models is a possible solution, but often sees limited improvements. In this paper, we analyze CL in the context of attention MIL models and find that the model forgetting is mainly concentrated in the attention layers of the MIL model. Using the results of this analysis we propose two components for improving CL on MIL:Attention Knowledge Distillation (AKD) and the Pseudo-Bag Memory Pool (PMP). AKD mitigates catastrophic forgetting by focusing on retaining attention layer knowledge between learning sessions, while PMP reduces the memory footprint by selectively storing only the most informative patches, or "pseudo-bags" from WSIs. Experimental evaluations demonstrate that our method significantly improves both accuracy and memory efficiency on diverse WSI datasets, outperforming current state-of-the-art CL methods. This work provides a foundation for CL in large-scale, weakly annotated clinical datasets, paving the way for more adaptable and resilient diagnostic models.

Hyperspectral imaging plays a critical role in numerous scientific and industrial fields. Conventional hyperspectral imaging systems often struggle with the trade-off between capture speed, spectral resolution, and bandwidth, particularly in dynamic environments. In this work, we present a novel event-based active hyperspectral imaging system designed for real-time capture with low bandwidth in dynamic scenes. By combining an event camera with a dynamic illumination strategy, our system achieves unprecedented temporal resolution while maintaining high spectral fidelity, all at a fraction of the bandwidth requirements of traditional systems. Unlike basis-based methods that sacrifice spectral resolution for efficiency, our approach enables continuous spectral sampling through an innovative "sweeping rainbow" illumination pattern synchronized with a rotating mirror array. The key insight is leveraging the sparse, asynchronous nature of event cameras to encode spectral variations as temporal contrasts, effectively transforming the spectral reconstruction problem into a series of geometric constraints. Extensive evaluations of both synthetic and real data demonstrate that our system outperforms state-of-the-art methods in temporal resolution while maintaining competitive spectral reconstruction quality.

Compressed Sensing MRI reconstructs images of the body's internal anatomy from undersampled measurements, thereby reducing the scan time - the time subjects need to remain still. Recently, deep learning has shown great potential for reconstructing high-fidelity images from highly undersampled measurements. However, one needs to train multiple models for different undersampling patterns and desired output image resolutions, since most networks operate on a fixed discretization. Such approaches are highly impractical in clinical settings, where undersampling patterns and image resolutions are frequently changed to accommodate different real-time imaging and diagnostic requirements. We propose a unified MRI reconstruction model robust to various measurement undersampling patterns and image resolutions. Our approach uses neural operators- a discretization-agnostic architecture applied in both image and measurement spaces--to capture local and global features. Empirically, our model improves SSIM by 11% and PSNR by 4dB over a state-of-the-art CNN (End-to-End VarNet), with inference 600x faster than diffusion methods. The resolution-agnostic design also enables zero-shot super-resolution and extended field-of-view reconstruction, offering a versatile and efficient solution for clinical MR imaging. Our unified model offers a versatile solution for MRI, adapting seamlessly to various measurement undersampling and imaging resolutions, making it highly effective for flexible and reliable clinical imaging. Our code is available at https://armeet.ca/nomri.

Hyperspectral fusion imaging is challenged by high computational cost due to the abundant spectral information. We find that pixels in regions with smooth spatial-spectral structure can be reconstructed well using a shallow network, while only those in regions with complex spatial-spectral structure require a deeper network. However, existing methods process all pixels uniformly, which ignores this property. To leverage this property, we propose a Selective Re-learning Fusion Network (SRLF) that initially extracts features from all pixels uniformly and then selectively refines distorted feature points. Specifically, SRLF first employs a Preliminary Fusion Module with robust global modeling capability to generate a preliminary fusion feature. Afterward, it applies a Selective Re-learning Module to focus on improving distorted feature points in the preliminary fusion feature. To achieve targeted learning, we present a novel Spatial-Spectral Structure-Guided Selective Re-learning Mechanism (SSG-SRL) that integrates the observation model to identify the feature points with spatial or spectral distortions. Only these distorted points are sent to the corresponding re-learning blocks, reducing both computational cost and the risk of overfitting. Finally, we develop an SRLF-Net, composed of multiple cascaded SRLFs, which surpasses multiple state-of-the-art methods on several datasets with minimal computational cost.

The search for exoplanets is an active field in astronomy, with direct imaging as one of the most challenging methods due to faint exoplanet signals buried within stronger residual starlight. Successful detection requires advanced image processing to separate the exoplanet signal from this nuisance component. This paper presents a novel statistical model that captures nuisance fluctuations using a multi-scale approach, leveraging problem symmetries and a joint spectral channel representation grounded in physical principles. Our model integrates into an interpretable, end-to-end learnable framework for simultaneous exoplanet detection and flux estimation. The proposed algorithm is evaluated against the state of the art using datasets from the SPHERE instrument operating at the Very Large Telescope (VLT). It significantly improves the precision-recall trade-off, notably on challenging datasets that are otherwise unusable by astronomers. The proposed approach is computationally efficient, robust to varying data quality, and well suited for large-scale observational surveys.